$Pantoprazole impairs fracture healing in aged mice$
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Pantoprazole impairs fracture healing in aged mice

Abstract Proton pump inhibitors (PPIs) belong to the most common medication in geriatric medicine. They are known to reduce osteoclast activity and to delay fracture healing in young adult mice. Because differentiation and proliferation in fracture healing as well as pharmacologic actions of drugs m...

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Autores principales:	Maximilian M. Menger, Philipp Bremer, Claudia Scheuer, Mika F. Rollmann, Benedikt J. Braun, Steven C. Herath, Marcel Orth, Thomas Später, Tim Pohlemann, Michael D. Menger, Tina Histing
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9208346d08c842aba0906e493f304071
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spelling	oai:doaj.org-article:9208346d08c842aba0906e493f3040712021-12-02T12:53:17ZPantoprazole impairs fracture healing in aged mice10.1038/s41598-020-79605-32045-2322https://doaj.org/article/9208346d08c842aba0906e493f3040712020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79605-3https://doaj.org/toc/2045-2322Abstract Proton pump inhibitors (PPIs) belong to the most common medication in geriatric medicine. They are known to reduce osteoclast activity and to delay fracture healing in young adult mice. Because differentiation and proliferation in fracture healing as well as pharmacologic actions of drugs markedly differ in the elderly compared to the young, we herein studied the effect of the PPI pantoprazole on bone healing in aged mice using a murine fracture model. Bone healing was analyzed by biomechanical, histomorphometric, radiological and protein biochemical analyses. The biomechanical analysis revealed a significantly reduced bending stiffness in pantoprazole-treated animals when compared to controls. This was associated with a decreased amount of bone tissue within the callus, a reduced trabecular thickness and a higher amount of fibrous tissue. Furthermore, the number of osteoclasts in pantoprazole-treated animals was significantly increased at 2 weeks and decreased at 5 weeks after fracture, indicating an acceleration of bone turnover. Western blot analysis showed a lower expression of the bone morphogenetic protein-4 (BMP-4), whereas the expression of the pro-angiogenic parameters was higher when compared to controls. Thus, pantoprazole impairs fracture healing in aged mice by affecting angiogenic and osteogenic growth factor expression, osteoclast activity and bone formation.Maximilian M. MengerPhilipp BremerClaudia ScheuerMika F. RollmannBenedikt J. BraunSteven C. HerathMarcel OrthThomas SpäterTim PohlemannMichael D. MengerTina HistingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maximilian M. Menger Philipp Bremer Claudia Scheuer Mika F. Rollmann Benedikt J. Braun Steven C. Herath Marcel Orth Thomas Später Tim Pohlemann Michael D. Menger Tina Histing Pantoprazole impairs fracture healing in aged mice
description	Abstract Proton pump inhibitors (PPIs) belong to the most common medication in geriatric medicine. They are known to reduce osteoclast activity and to delay fracture healing in young adult mice. Because differentiation and proliferation in fracture healing as well as pharmacologic actions of drugs markedly differ in the elderly compared to the young, we herein studied the effect of the PPI pantoprazole on bone healing in aged mice using a murine fracture model. Bone healing was analyzed by biomechanical, histomorphometric, radiological and protein biochemical analyses. The biomechanical analysis revealed a significantly reduced bending stiffness in pantoprazole-treated animals when compared to controls. This was associated with a decreased amount of bone tissue within the callus, a reduced trabecular thickness and a higher amount of fibrous tissue. Furthermore, the number of osteoclasts in pantoprazole-treated animals was significantly increased at 2 weeks and decreased at 5 weeks after fracture, indicating an acceleration of bone turnover. Western blot analysis showed a lower expression of the bone morphogenetic protein-4 (BMP-4), whereas the expression of the pro-angiogenic parameters was higher when compared to controls. Thus, pantoprazole impairs fracture healing in aged mice by affecting angiogenic and osteogenic growth factor expression, osteoclast activity and bone formation.
format	article
author	Maximilian M. Menger Philipp Bremer Claudia Scheuer Mika F. Rollmann Benedikt J. Braun Steven C. Herath Marcel Orth Thomas Später Tim Pohlemann Michael D. Menger Tina Histing
author_facet	Maximilian M. Menger Philipp Bremer Claudia Scheuer Mika F. Rollmann Benedikt J. Braun Steven C. Herath Marcel Orth Thomas Später Tim Pohlemann Michael D. Menger Tina Histing
author_sort	Maximilian M. Menger
title	Pantoprazole impairs fracture healing in aged mice
title_short	Pantoprazole impairs fracture healing in aged mice
title_full	Pantoprazole impairs fracture healing in aged mice
title_fullStr	Pantoprazole impairs fracture healing in aged mice
title_full_unstemmed	Pantoprazole impairs fracture healing in aged mice
title_sort	pantoprazole impairs fracture healing in aged mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9208346d08c842aba0906e493f304071
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Pantoprazole impairs fracture healing in aged mice

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