Connecting two proteins using a fusion alpha helix stabilized by a chemical cross linker

Linking protein components in a controlled manner is crucial for assembling protein nanostructures with pre-determined architecture. Here, the authors use a chemical cross-linker to fuse the terminal helices of two proteins into a single one, forcing the protein domains in a specific orientation.

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Detalles Bibliográficos
Autores principales: Woo Hyeon Jeong, Haerim Lee, Dong Hyun Song, Jae-Hoon Eom, Sun Chang Kim, Hee-Seung Lee, Hayyoung Lee, Jie-Oh Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/92098307f65f4bc7afd1adb4559ec18b
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