The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia

Bone marrow (BM) is a highly complex tissue that provides important regulatory signals to orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well characterized niches to produce molecular and cellular mechanisms that interfere with differentiation, migration, survi...

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Autores principales:	Débora Bifano Pimenta, Vanessa Araujo Varela, Tarcila Santos Datoguia, Victória Bulcão Caraciolo, Gabriel Herculano Lopes, Welbert Oliveira Pereira
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	acute myeloid leukemia bone marrow endosteal niche vascular niche reticular niche molecular targets Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/920e4984ac054fb3887cb75c441b0d6b
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spelling	oai:doaj.org-article:920e4984ac054fb3887cb75c441b0d6b2021-11-19T05:03:51ZThe Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia2296-634X10.3389/fcell.2021.764698https://doaj.org/article/920e4984ac054fb3887cb75c441b0d6b2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.764698/fullhttps://doaj.org/toc/2296-634XBone marrow (BM) is a highly complex tissue that provides important regulatory signals to orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well characterized niches to produce molecular and cellular mechanisms that interfere with differentiation, migration, survival, and proliferation in this microenvironment. The acute myeloid leukemia (AML), the most common and severe hematological neoplasm in adults, arises and develop in the BM. The osteoblastic, vascular, and reticular niches provide surface co-receptors, soluble factors, cytokines, and chemokines that mediate important functions on hematopoietic cells and leukemic blasts. There are some evidences of how AML modify the architecture and function of these three BM niches, but it has been still unclear how essential those modifications are to maintain AML development. Basic studies and clinical trials have been suggesting that disturbing specific cells and molecules into the BM niches might be able to impair leukemia competencies. Either through niche-specific molecule inhibition alone or in combination with more traditional drugs, the bone marrow microenvironment is currently considered the potential target for new strategies to treat AML patients. This review describes the cellular and molecular constitution of the BM niches under healthy and AML conditions, presenting this anatomical compartment by a new perspective: as a prospective target for current and next generation therapies.Débora Bifano PimentaVanessa Araujo VarelaTarcila Santos DatoguiaVictória Bulcão CaracioloGabriel Herculano LopesWelbert Oliveira PereiraFrontiers Media S.A.articleacute myeloid leukemiabone marrowendosteal nichevascular nichereticular nichemolecular targetsBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute myeloid leukemia bone marrow endosteal niche vascular niche reticular niche molecular targets Biology (General) QH301-705.5
spellingShingle	acute myeloid leukemia bone marrow endosteal niche vascular niche reticular niche molecular targets Biology (General) QH301-705.5 Débora Bifano Pimenta Vanessa Araujo Varela Tarcila Santos Datoguia Victória Bulcão Caraciolo Gabriel Herculano Lopes Welbert Oliveira Pereira The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia
description	Bone marrow (BM) is a highly complex tissue that provides important regulatory signals to orchestrate hematopoiesis. Resident and transient cells occupy and interact with some well characterized niches to produce molecular and cellular mechanisms that interfere with differentiation, migration, survival, and proliferation in this microenvironment. The acute myeloid leukemia (AML), the most common and severe hematological neoplasm in adults, arises and develop in the BM. The osteoblastic, vascular, and reticular niches provide surface co-receptors, soluble factors, cytokines, and chemokines that mediate important functions on hematopoietic cells and leukemic blasts. There are some evidences of how AML modify the architecture and function of these three BM niches, but it has been still unclear how essential those modifications are to maintain AML development. Basic studies and clinical trials have been suggesting that disturbing specific cells and molecules into the BM niches might be able to impair leukemia competencies. Either through niche-specific molecule inhibition alone or in combination with more traditional drugs, the bone marrow microenvironment is currently considered the potential target for new strategies to treat AML patients. This review describes the cellular and molecular constitution of the BM niches under healthy and AML conditions, presenting this anatomical compartment by a new perspective: as a prospective target for current and next generation therapies.
format	article
author	Débora Bifano Pimenta Vanessa Araujo Varela Tarcila Santos Datoguia Victória Bulcão Caraciolo Gabriel Herculano Lopes Welbert Oliveira Pereira
author_facet	Débora Bifano Pimenta Vanessa Araujo Varela Tarcila Santos Datoguia Victória Bulcão Caraciolo Gabriel Herculano Lopes Welbert Oliveira Pereira
author_sort	Débora Bifano Pimenta
title	The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia
title_short	The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia
title_full	The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia
title_fullStr	The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia
title_full_unstemmed	The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia
title_sort	bone marrow microenvironment mechanisms in acute myeloid leukemia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/920e4984ac054fb3887cb75c441b0d6b
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The Bone Marrow Microenvironment Mechanisms in Acute Myeloid Leukemia

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