mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline

The cellular origins of lymphangioleiomyomatosis (LAM), a rare fatal lung disease, are poorly understood. Here the authors identify a mesenchymal cell hub coordinating the LAM phenotype and develop a LAM mouse model where they investigate the co-operative dysregulation of mTORC1 and WNT growth pathw...

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Autores principales:	Kseniya Obraztsova, Maria C. Basil, Ryan Rue, Aravind Sivakumar, Susan M. Lin, Alexander R. Mukhitov, Andrei I. Gritsiuta, Jilly F. Evans, Meghan Kopp, Jeremy Katzen, Annette Robichaud, Elena N. Atochina-Vasserman, Shanru Li, Justine Carl, Apoorva Babu, Michael P. Morley, Edward Cantu, Michael F. Beers, David B. Frank, Edward E. Morrisey, Vera P. Krymskaya
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/920f2bde4ce048d5a6bf73943fc2fe6e
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spelling	oai:doaj.org-article:920f2bde4ce048d5a6bf73943fc2fe6e2021-12-02T14:41:05ZmTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline10.1038/s41467-020-18979-42041-1723https://doaj.org/article/920f2bde4ce048d5a6bf73943fc2fe6e2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18979-4https://doaj.org/toc/2041-1723The cellular origins of lymphangioleiomyomatosis (LAM), a rare fatal lung disease, are poorly understood. Here the authors identify a mesenchymal cell hub coordinating the LAM phenotype and develop a LAM mouse model where they investigate the co-operative dysregulation of mTORC1 and WNT growth pathways in the sex- and age-specific changes leading to structural and functional decline.Kseniya ObraztsovaMaria C. BasilRyan RueAravind SivakumarSusan M. LinAlexander R. MukhitovAndrei I. GritsiutaJilly F. EvansMeghan KoppJeremy KatzenAnnette RobichaudElena N. Atochina-VassermanShanru LiJustine CarlApoorva BabuMichael P. MorleyEdward CantuMichael F. BeersDavid B. FrankEdward E. MorriseyVera P. KrymskayaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kseniya Obraztsova Maria C. Basil Ryan Rue Aravind Sivakumar Susan M. Lin Alexander R. Mukhitov Andrei I. Gritsiuta Jilly F. Evans Meghan Kopp Jeremy Katzen Annette Robichaud Elena N. Atochina-Vasserman Shanru Li Justine Carl Apoorva Babu Michael P. Morley Edward Cantu Michael F. Beers David B. Frank Edward E. Morrisey Vera P. Krymskaya mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
description	The cellular origins of lymphangioleiomyomatosis (LAM), a rare fatal lung disease, are poorly understood. Here the authors identify a mesenchymal cell hub coordinating the LAM phenotype and develop a LAM mouse model where they investigate the co-operative dysregulation of mTORC1 and WNT growth pathways in the sex- and age-specific changes leading to structural and functional decline.
format	article
author	Kseniya Obraztsova Maria C. Basil Ryan Rue Aravind Sivakumar Susan M. Lin Alexander R. Mukhitov Andrei I. Gritsiuta Jilly F. Evans Meghan Kopp Jeremy Katzen Annette Robichaud Elena N. Atochina-Vasserman Shanru Li Justine Carl Apoorva Babu Michael P. Morley Edward Cantu Michael F. Beers David B. Frank Edward E. Morrisey Vera P. Krymskaya
author_facet	Kseniya Obraztsova Maria C. Basil Ryan Rue Aravind Sivakumar Susan M. Lin Alexander R. Mukhitov Andrei I. Gritsiuta Jilly F. Evans Meghan Kopp Jeremy Katzen Annette Robichaud Elena N. Atochina-Vasserman Shanru Li Justine Carl Apoorva Babu Michael P. Morley Edward Cantu Michael F. Beers David B. Frank Edward E. Morrisey Vera P. Krymskaya
author_sort	Kseniya Obraztsova
title	mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
title_short	mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
title_full	mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
title_fullStr	mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
title_full_unstemmed	mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
title_sort	mtorc1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/920f2bde4ce048d5a6bf73943fc2fe6e
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mTORC1 activation in lung mesenchyme drives sex- and age-dependent pulmonary structure and function decline

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