A high throughput screen for next-generation leads targeting malaria parasite transmission

Sexual forms of malaria parasites are responsible for transmission to the mosquito. Anti-malarial drug resistance remains a serious problem and requires advent of new drug therapies. Here, the authors present a high-throughput screen of potential antimalarial compounds, identifying seventeen drug-li...

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Autores principales:	Michael J. Delves, Celia Miguel-Blanco, Holly Matthews, Irene Molina, Andrea Ruecker, Sabrina Yahiya, Ursula Straschil, Matthew Abraham, María Luisa León, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Jochen R. Brandt, Álvaro Cortés, Anna Barnard, Matthew J. Fuchter, Félix Calderón, Elizabeth A. Winzeler, Robert E. Sinden, Esperanza Herreros, Francisco J. Gamo, Jake Baum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/920f37303ca446e0a2ceaa2cbd0d76bf
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spelling	oai:doaj.org-article:920f37303ca446e0a2ceaa2cbd0d76bf2021-12-02T14:40:32ZA high throughput screen for next-generation leads targeting malaria parasite transmission10.1038/s41467-018-05777-22041-1723https://doaj.org/article/920f37303ca446e0a2ceaa2cbd0d76bf2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05777-2https://doaj.org/toc/2041-1723Sexual forms of malaria parasites are responsible for transmission to the mosquito. Anti-malarial drug resistance remains a serious problem and requires advent of new drug therapies. Here, the authors present a high-throughput screen of potential antimalarial compounds, identifying seventeen drug-like molecules specifically targeting transmission.Michael J. DelvesCelia Miguel-BlancoHolly MatthewsIrene MolinaAndrea RueckerSabrina YahiyaUrsula StraschilMatthew AbrahamMaría Luisa LeónOliver J. FischerAinoa Rueda-ZubiaurreJochen R. BrandtÁlvaro CortésAnna BarnardMatthew J. FuchterFélix CalderónElizabeth A. WinzelerRobert E. SindenEsperanza HerrerosFrancisco J. GamoJake BaumNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. Delves Celia Miguel-Blanco Holly Matthews Irene Molina Andrea Ruecker Sabrina Yahiya Ursula Straschil Matthew Abraham María Luisa León Oliver J. Fischer Ainoa Rueda-Zubiaurre Jochen R. Brandt Álvaro Cortés Anna Barnard Matthew J. Fuchter Félix Calderón Elizabeth A. Winzeler Robert E. Sinden Esperanza Herreros Francisco J. Gamo Jake Baum A high throughput screen for next-generation leads targeting malaria parasite transmission
description	Sexual forms of malaria parasites are responsible for transmission to the mosquito. Anti-malarial drug resistance remains a serious problem and requires advent of new drug therapies. Here, the authors present a high-throughput screen of potential antimalarial compounds, identifying seventeen drug-like molecules specifically targeting transmission.
format	article
author	Michael J. Delves Celia Miguel-Blanco Holly Matthews Irene Molina Andrea Ruecker Sabrina Yahiya Ursula Straschil Matthew Abraham María Luisa León Oliver J. Fischer Ainoa Rueda-Zubiaurre Jochen R. Brandt Álvaro Cortés Anna Barnard Matthew J. Fuchter Félix Calderón Elizabeth A. Winzeler Robert E. Sinden Esperanza Herreros Francisco J. Gamo Jake Baum
author_facet	Michael J. Delves Celia Miguel-Blanco Holly Matthews Irene Molina Andrea Ruecker Sabrina Yahiya Ursula Straschil Matthew Abraham María Luisa León Oliver J. Fischer Ainoa Rueda-Zubiaurre Jochen R. Brandt Álvaro Cortés Anna Barnard Matthew J. Fuchter Félix Calderón Elizabeth A. Winzeler Robert E. Sinden Esperanza Herreros Francisco J. Gamo Jake Baum
author_sort	Michael J. Delves
title	A high throughput screen for next-generation leads targeting malaria parasite transmission
title_short	A high throughput screen for next-generation leads targeting malaria parasite transmission
title_full	A high throughput screen for next-generation leads targeting malaria parasite transmission
title_fullStr	A high throughput screen for next-generation leads targeting malaria parasite transmission
title_full_unstemmed	A high throughput screen for next-generation leads targeting malaria parasite transmission
title_sort	high throughput screen for next-generation leads targeting malaria parasite transmission
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/920f37303ca446e0a2ceaa2cbd0d76bf
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A high throughput screen for next-generation leads targeting malaria parasite transmission

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