In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.

The mitochondrial tumor suppressor 1 (MTUS1) gene acts as a crucial tumor suppressor by inhibiting growth and proliferation of eukaryotic cells including tumor cell lines. Down regulation of MTUS1 gene has been implicated in a wide range of cancers as well as various human diseases. Alteration throu...

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Autores principales:	Liza Teresa Rozario, Tanima Sharker, Tasnin Akter Nila
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9216ab1e4e744cd3b98882f48f7cd287
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spelling	oai:doaj.org-article:9216ab1e4e744cd3b98882f48f7cd2872021-12-02T20:15:49ZIn silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.1932-620310.1371/journal.pone.0252932https://doaj.org/article/9216ab1e4e744cd3b98882f48f7cd2872021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252932https://doaj.org/toc/1932-6203The mitochondrial tumor suppressor 1 (MTUS1) gene acts as a crucial tumor suppressor by inhibiting growth and proliferation of eukaryotic cells including tumor cell lines. Down regulation of MTUS1 gene has been implicated in a wide range of cancers as well as various human diseases. Alteration through nsSNPs can potentially damage the structure and/or function of the protein. As characterization of functional SNPs in such disease linked genes is a major challenge, it is feasible to analyze putative functional SNPs prior to performing larger population studies. Hence, in this in silico study we differentiated the potentially harmful nsSNPs of the MTUS1 gene from the neutral ones by using various sequence and structure based bioinformatic tools. In a total of 215 nsSNPs, 9 were found to be most likely to exert deleterious effect using 7 prediction tools. From which, 5nsSNPs (S1259L, E960K, P503T, L1084V and L1143Q) were selected as potentially damaging due to their presence in the highly conserved region and ability to decrease protein stability. In fact, 2 nsSNPs (S1259L and E960K) among these 5 were found to be individually associated with two distinctive cancers named Stomach adenocarcinoma and Uterine corpus endometrial carcinoma. As this is the first comprehensive study analyzing the functional nsSNPs of MTUS1, the results of the current study would certainly be helpful in future prospects concerning large population-based studies as well as drug discovery, especially developing individualized medicine.Liza Teresa RozarioTanima SharkerTasnin Akter NilaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252932 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liza Teresa Rozario Tanima Sharker Tasnin Akter Nila In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.
description	The mitochondrial tumor suppressor 1 (MTUS1) gene acts as a crucial tumor suppressor by inhibiting growth and proliferation of eukaryotic cells including tumor cell lines. Down regulation of MTUS1 gene has been implicated in a wide range of cancers as well as various human diseases. Alteration through nsSNPs can potentially damage the structure and/or function of the protein. As characterization of functional SNPs in such disease linked genes is a major challenge, it is feasible to analyze putative functional SNPs prior to performing larger population studies. Hence, in this in silico study we differentiated the potentially harmful nsSNPs of the MTUS1 gene from the neutral ones by using various sequence and structure based bioinformatic tools. In a total of 215 nsSNPs, 9 were found to be most likely to exert deleterious effect using 7 prediction tools. From which, 5nsSNPs (S1259L, E960K, P503T, L1084V and L1143Q) were selected as potentially damaging due to their presence in the highly conserved region and ability to decrease protein stability. In fact, 2 nsSNPs (S1259L and E960K) among these 5 were found to be individually associated with two distinctive cancers named Stomach adenocarcinoma and Uterine corpus endometrial carcinoma. As this is the first comprehensive study analyzing the functional nsSNPs of MTUS1, the results of the current study would certainly be helpful in future prospects concerning large population-based studies as well as drug discovery, especially developing individualized medicine.
format	article
author	Liza Teresa Rozario Tanima Sharker Tasnin Akter Nila
author_facet	Liza Teresa Rozario Tanima Sharker Tasnin Akter Nila
author_sort	Liza Teresa Rozario
title	In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.
title_short	In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.
title_full	In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.
title_fullStr	In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.
title_full_unstemmed	In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.
title_sort	in silico analysis of deleterious snps of human mtus1 gene and their impacts on subsequent protein structure and function.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9216ab1e4e744cd3b98882f48f7cd287
work_keys_str_mv	AT lizateresarozario insilicoanalysisofdeleterioussnpsofhumanmtus1geneandtheirimpactsonsubsequentproteinstructureandfunction AT tanimasharker insilicoanalysisofdeleterioussnpsofhumanmtus1geneandtheirimpactsonsubsequentproteinstructureandfunction AT tasninakternila insilicoanalysisofdeleterioussnpsofhumanmtus1geneandtheirimpactsonsubsequentproteinstructureandfunction
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In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function.

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