Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

In tumours aberrant epigenetic modifications can alter the transcriptional state. Here, the authors identify a common tumour-specific shift to transcriptional repression associated with DNA methylation and chromatin dysregulation at the transcription start site.

Guardado en:

Detalles Bibliográficos
Autores principales:	Mizuo Ando, Yuki Saito, Guorong Xu, Nam Q. Bui, Kate Medetgul-Ernar, Minya Pu, Kathleen Fisch, Shuling Ren, Akihiro Sakai, Takahito Fukusumi, Chao Liu, Sunny Haft, John Pang, Adam Mark, Daria A. Gaykalova, Theresa Guo, Alexander V. Favorov, Srinivasan Yegnasubramanian, Elana J. Fertig, Patrick Ha, Pablo Tamayo, Tatsuya Yamasoba, Trey Ideker, Karen Messer, Joseph A. Califano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92171efeb0c747ec87436ef09a8ab860
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92171efeb0c747ec87436ef09a8ab860
record_format	dspace
spelling	oai:doaj.org-article:92171efeb0c747ec87436ef09a8ab8602021-12-02T14:40:21ZChromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers10.1038/s41467-019-09937-w2041-1723https://doaj.org/article/92171efeb0c747ec87436ef09a8ab8602019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09937-whttps://doaj.org/toc/2041-1723In tumours aberrant epigenetic modifications can alter the transcriptional state. Here, the authors identify a common tumour-specific shift to transcriptional repression associated with DNA methylation and chromatin dysregulation at the transcription start site.Mizuo AndoYuki SaitoGuorong XuNam Q. BuiKate Medetgul-ErnarMinya PuKathleen FischShuling RenAkihiro SakaiTakahito FukusumiChao LiuSunny HaftJohn PangAdam MarkDaria A. GaykalovaTheresa GuoAlexander V. FavorovSrinivasan YegnasubramanianElana J. FertigPatrick HaPablo TamayoTatsuya YamasobaTrey IdekerKaren MesserJoseph A. CalifanoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mizuo Ando Yuki Saito Guorong Xu Nam Q. Bui Kate Medetgul-Ernar Minya Pu Kathleen Fisch Shuling Ren Akihiro Sakai Takahito Fukusumi Chao Liu Sunny Haft John Pang Adam Mark Daria A. Gaykalova Theresa Guo Alexander V. Favorov Srinivasan Yegnasubramanian Elana J. Fertig Patrick Ha Pablo Tamayo Tatsuya Yamasoba Trey Ideker Karen Messer Joseph A. Califano Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
description	In tumours aberrant epigenetic modifications can alter the transcriptional state. Here, the authors identify a common tumour-specific shift to transcriptional repression associated with DNA methylation and chromatin dysregulation at the transcription start site.
format	article
author	Mizuo Ando Yuki Saito Guorong Xu Nam Q. Bui Kate Medetgul-Ernar Minya Pu Kathleen Fisch Shuling Ren Akihiro Sakai Takahito Fukusumi Chao Liu Sunny Haft John Pang Adam Mark Daria A. Gaykalova Theresa Guo Alexander V. Favorov Srinivasan Yegnasubramanian Elana J. Fertig Patrick Ha Pablo Tamayo Tatsuya Yamasoba Trey Ideker Karen Messer Joseph A. Califano
author_facet	Mizuo Ando Yuki Saito Guorong Xu Nam Q. Bui Kate Medetgul-Ernar Minya Pu Kathleen Fisch Shuling Ren Akihiro Sakai Takahito Fukusumi Chao Liu Sunny Haft John Pang Adam Mark Daria A. Gaykalova Theresa Guo Alexander V. Favorov Srinivasan Yegnasubramanian Elana J. Fertig Patrick Ha Pablo Tamayo Tatsuya Yamasoba Trey Ideker Karen Messer Joseph A. Califano
author_sort	Mizuo Ando
title	Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
title_short	Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
title_full	Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
title_fullStr	Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
title_full_unstemmed	Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers
title_sort	chromatin dysregulation and dna methylation at transcription start sites associated with transcriptional repression in cancers
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/92171efeb0c747ec87436ef09a8ab860
work_keys_str_mv	AT mizuoando chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT yukisaito chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT guorongxu chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT namqbui chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT katemedetgulernar chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT minyapu chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT kathleenfisch chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT shulingren chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT akihirosakai chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT takahitofukusumi chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT chaoliu chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT sunnyhaft chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT johnpang chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT adammark chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT dariaagaykalova chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT theresaguo chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT alexandervfavorov chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT srinivasanyegnasubramanian chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT elanajfertig chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT patrickha chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT pablotamayo chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT tatsuyayamasoba chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT treyideker chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT karenmesser chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers AT josephacalifano chromatindysregulationanddnamethylationattranscriptionstartsitesassociatedwithtranscriptionalrepressionincancers
_version_	1718390310050988032

Chromatin dysregulation and DNA methylation at transcription start sites associated with transcriptional repression in cancers

Ejemplares similares