Prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study

Abstract Background Malnutrition is associated with poor prognosis in cardiovascular disease patients or in diabetic patients. However, the relationship between malnutrition and clinical outcomes in diabetic patients with coronary artery disease (CAD) is not well known. The aim of this study is to r...

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Autores principales:	Wen Wei, Lingyu Zhang, Guode Li, Zhidong Huang, Jin Liu, Zhihuang Wu, Yuanying Wu, Jinrong Lin, Yunhan Zhang, Yaren Yu, Haozhang Huang, Qiang Li, Bo Wang, Yong Liu, Mei Tu, Hong Chen, Shiqun Chen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Malnutrition Diabetic Coronary artery disease Prevalence Prognosis Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/92189f7ceca14a628324cf80d64b2e2c
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spelling	oai:doaj.org-article:92189f7ceca14a628324cf80d64b2e2c2021-11-28T12:13:38ZPrevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study10.1186/s12986-021-00626-41743-7075https://doaj.org/article/92189f7ceca14a628324cf80d64b2e2c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12986-021-00626-4https://doaj.org/toc/1743-7075Abstract Background Malnutrition is associated with poor prognosis in cardiovascular disease patients or in diabetic patients. However, the relationship between malnutrition and clinical outcomes in diabetic patients with coronary artery disease (CAD) is not well known. The aim of this study is to report the prevalence and prognostic consequences of malnutrition in diabetic patients with CAD. Methods In this retrospective observational study, the Controlling Nutritional Status (CONUT) score applied to 12,898 consecutive diabetic patients with CAD. The association between malnutrition and long-term all-cause mortality was examined using Cox proportional hazards regression analysis. Results According to CONUT score, 60.5% patients suffered from malnutrition; 46.4%, 13.2%, and 0.9% patients had mild, moderate, and severe malnutrition, respectively. During a median follow-up of 4.88 (2.83–7.51) years, 1973 (15.3%) patients died. After adjustment for confounders, malnutrition was associated with significantly increased risk for long-term all-cause mortality (adjusted hazard ratio for mild malnutrition and moderate to severe malnutrition, respectively: 1.38 [95% confidence interval (CI) 1.07–1.77]; P value = 0.012 and 1.63 [95% CI 1.18–2.24]; P value = 0.003). A similar association was observed around subgroups. Conclusions Malnutrition is common in diabetic patients with CAD and is strongly associated with increased mortality. It is necessary to adequately assess the nutritional status and take the effective nutritional guidance to improve the prognosis of diabetic patients with CAD.Wen WeiLingyu ZhangGuode LiZhidong HuangJin LiuZhihuang WuYuanying WuJinrong LinYunhan ZhangYaren YuHaozhang HuangQiang LiBo WangYong LiuMei TuHong ChenShiqun ChenBMCarticleMalnutritionDiabeticCoronary artery diseasePrevalencePrognosisNutrition. Foods and food supplyTX341-641Nutritional diseases. Deficiency diseasesRC620-627ENNutrition & Metabolism, Vol 18, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Malnutrition Diabetic Coronary artery disease Prevalence Prognosis Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Malnutrition Diabetic Coronary artery disease Prevalence Prognosis Nutrition. Foods and food supply TX341-641 Nutritional diseases. Deficiency diseases RC620-627 Wen Wei Lingyu Zhang Guode Li Zhidong Huang Jin Liu Zhihuang Wu Yuanying Wu Jinrong Lin Yunhan Zhang Yaren Yu Haozhang Huang Qiang Li Bo Wang Yong Liu Mei Tu Hong Chen Shiqun Chen Prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study
description	Abstract Background Malnutrition is associated with poor prognosis in cardiovascular disease patients or in diabetic patients. However, the relationship between malnutrition and clinical outcomes in diabetic patients with coronary artery disease (CAD) is not well known. The aim of this study is to report the prevalence and prognostic consequences of malnutrition in diabetic patients with CAD. Methods In this retrospective observational study, the Controlling Nutritional Status (CONUT) score applied to 12,898 consecutive diabetic patients with CAD. The association between malnutrition and long-term all-cause mortality was examined using Cox proportional hazards regression analysis. Results According to CONUT score, 60.5% patients suffered from malnutrition; 46.4%, 13.2%, and 0.9% patients had mild, moderate, and severe malnutrition, respectively. During a median follow-up of 4.88 (2.83–7.51) years, 1973 (15.3%) patients died. After adjustment for confounders, malnutrition was associated with significantly increased risk for long-term all-cause mortality (adjusted hazard ratio for mild malnutrition and moderate to severe malnutrition, respectively: 1.38 [95% confidence interval (CI) 1.07–1.77]; P value = 0.012 and 1.63 [95% CI 1.18–2.24]; P value = 0.003). A similar association was observed around subgroups. Conclusions Malnutrition is common in diabetic patients with CAD and is strongly associated with increased mortality. It is necessary to adequately assess the nutritional status and take the effective nutritional guidance to improve the prognosis of diabetic patients with CAD.
format	article
author	Wen Wei Lingyu Zhang Guode Li Zhidong Huang Jin Liu Zhihuang Wu Yuanying Wu Jinrong Lin Yunhan Zhang Yaren Yu Haozhang Huang Qiang Li Bo Wang Yong Liu Mei Tu Hong Chen Shiqun Chen
author_facet	Wen Wei Lingyu Zhang Guode Li Zhidong Huang Jin Liu Zhihuang Wu Yuanying Wu Jinrong Lin Yunhan Zhang Yaren Yu Haozhang Huang Qiang Li Bo Wang Yong Liu Mei Tu Hong Chen Shiqun Chen
author_sort	Wen Wei
title	Prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study
title_short	Prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study
title_full	Prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study
title_fullStr	Prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study
title_full_unstemmed	Prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study
title_sort	prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/92189f7ceca14a628324cf80d64b2e2c
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Prevalence and prognostic significance of malnutrition in diabetic patients with coronary artery disease: a cohort study

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