BIOCHEMICAL AND ENDOSCOPIC EVALUATION OF UPPER-GASTROINTESTINAL BLEED IN PATIENTS WITH LIVER CIRRHOSIS

Objectives: Evaluating the causes of UGIB, their relation with Child-Turcotte-Pugh (CTP) score and biochemicalmarkers and the predictors of varices. Study Design: Prospective comparative study. Place and Duration of Study: Fauji Foundation Hospital Rawalpindi, from Jan 2016 to Jul 2017. Met...

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Autores principales:	Zubia Jamil, Omar Ahsan, Qurat Ul Ain, Maryam Malik
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2019
Materias:	esophageal and gastric varices gastrointestinal haemorrhage liver disease Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/921a3b097f454927aca6015ddeee83f1
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spelling	oai:doaj.org-article:921a3b097f454927aca6015ddeee83f12021-11-10T03:27:38ZBIOCHEMICAL AND ENDOSCOPIC EVALUATION OF UPPER-GASTROINTESTINAL BLEED IN PATIENTS WITH LIVER CIRRHOSIS0030-96482411-8842https://doaj.org/article/921a3b097f454927aca6015ddeee83f12019-10-01T00:00:00Zhttps://www.pafmj.org/index.php/PAFMJ/article/view/3422/2397https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objectives: Evaluating the causes of UGIB, their relation with Child-Turcotte-Pugh (CTP) score and biochemicalmarkers and the predictors of varices. Study Design: Prospective comparative study. Place and Duration of Study: Fauji Foundation Hospital Rawalpindi, from Jan 2016 to Jul 2017. Methodology: The study population consisted of 256 patients with chronic liver disease who underwent upper gastrointestinal endoscopy to evaluate the cause of UGIB. Both variceal and non-variceal causes were notified. The patients were classified into class A, B and C according to CTP score. The relationship of varices with CTP score and biochemical findings were studied. The predictors of varices were also found by regression analysis. Results: Gastroesophageal varices were present in 73.6% patients and 26.3% patients had non-variceal bleeding. Portal hypertensive gastropathy was the most common cause of non-variceal bleeding (20.5%). The presence and grades of varices were associated with CTP score (p<0.05). Class C had more advanced varices compared to Class A. Low platelets and albumin while high bilirubin, PT, INR and CTP class were prognosticators of varices. Conclusion: Although a substantial portion bleeds due to variceal haemorrhage, non-variceal causes of UGIB were also not uncommon. Both pathologies resulted in substantial mortality. The advanced liver cirrhosis was associated with higher grades of varices. Blood chemistry markers helped in differentiating the two causes and manage them accordingly.Zubia JamilOmar AhsanQurat Ul AinMaryam MalikArmy Medical College Rawalpindiarticleesophageal and gastric varicesgastrointestinal haemorrhageliver diseaseMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 69, Iss 5, Pp 1103-1110 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	esophageal and gastric varices gastrointestinal haemorrhage liver disease Medicine R Medicine (General) R5-920
spellingShingle	esophageal and gastric varices gastrointestinal haemorrhage liver disease Medicine R Medicine (General) R5-920 Zubia Jamil Omar Ahsan Qurat Ul Ain Maryam Malik BIOCHEMICAL AND ENDOSCOPIC EVALUATION OF UPPER-GASTROINTESTINAL BLEED IN PATIENTS WITH LIVER CIRRHOSIS
description	Objectives: Evaluating the causes of UGIB, their relation with Child-Turcotte-Pugh (CTP) score and biochemicalmarkers and the predictors of varices. Study Design: Prospective comparative study. Place and Duration of Study: Fauji Foundation Hospital Rawalpindi, from Jan 2016 to Jul 2017. Methodology: The study population consisted of 256 patients with chronic liver disease who underwent upper gastrointestinal endoscopy to evaluate the cause of UGIB. Both variceal and non-variceal causes were notified. The patients were classified into class A, B and C according to CTP score. The relationship of varices with CTP score and biochemical findings were studied. The predictors of varices were also found by regression analysis. Results: Gastroesophageal varices were present in 73.6% patients and 26.3% patients had non-variceal bleeding. Portal hypertensive gastropathy was the most common cause of non-variceal bleeding (20.5%). The presence and grades of varices were associated with CTP score (p<0.05). Class C had more advanced varices compared to Class A. Low platelets and albumin while high bilirubin, PT, INR and CTP class were prognosticators of varices. Conclusion: Although a substantial portion bleeds due to variceal haemorrhage, non-variceal causes of UGIB were also not uncommon. Both pathologies resulted in substantial mortality. The advanced liver cirrhosis was associated with higher grades of varices. Blood chemistry markers helped in differentiating the two causes and manage them accordingly.
format	article
author	Zubia Jamil Omar Ahsan Qurat Ul Ain Maryam Malik
author_facet	Zubia Jamil Omar Ahsan Qurat Ul Ain Maryam Malik
author_sort	Zubia Jamil
title	BIOCHEMICAL AND ENDOSCOPIC EVALUATION OF UPPER-GASTROINTESTINAL BLEED IN PATIENTS WITH LIVER CIRRHOSIS
title_short	BIOCHEMICAL AND ENDOSCOPIC EVALUATION OF UPPER-GASTROINTESTINAL BLEED IN PATIENTS WITH LIVER CIRRHOSIS
title_full	BIOCHEMICAL AND ENDOSCOPIC EVALUATION OF UPPER-GASTROINTESTINAL BLEED IN PATIENTS WITH LIVER CIRRHOSIS
title_fullStr	BIOCHEMICAL AND ENDOSCOPIC EVALUATION OF UPPER-GASTROINTESTINAL BLEED IN PATIENTS WITH LIVER CIRRHOSIS
title_full_unstemmed	BIOCHEMICAL AND ENDOSCOPIC EVALUATION OF UPPER-GASTROINTESTINAL BLEED IN PATIENTS WITH LIVER CIRRHOSIS
title_sort	biochemical and endoscopic evaluation of upper-gastrointestinal bleed in patients with liver cirrhosis
publisher	Army Medical College Rawalpindi
publishDate	2019
url	https://doaj.org/article/921a3b097f454927aca6015ddeee83f1
work_keys_str_mv	AT zubiajamil biochemicalandendoscopicevaluationofuppergastrointestinalbleedinpatientswithlivercirrhosis AT omarahsan biochemicalandendoscopicevaluationofuppergastrointestinalbleedinpatientswithlivercirrhosis AT quratulain biochemicalandendoscopicevaluationofuppergastrointestinalbleedinpatientswithlivercirrhosis AT maryammalik biochemicalandendoscopicevaluationofuppergastrointestinalbleedinpatientswithlivercirrhosis
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BIOCHEMICAL AND ENDOSCOPIC EVALUATION OF UPPER-GASTROINTESTINAL BLEED IN PATIENTS WITH LIVER CIRRHOSIS

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