Establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis

ObjectiveTo establish a nomogram for predicting the risk of post-hepatectomy complications (PHC) in hepatic echinococcosis by analyzing the risk factors for PHC in two types of hepatic echinococcosis, and to investigate its value in clinical practice. MethodsA retrospective analysis was performed fo...

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Autor principal:	GUO Bing
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Department of Journal of Clinical Hepatology 2021
Materias:	Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/921a7697879a42dba10ccc358edd4b03
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spelling	oai:doaj.org-article:921a7697879a42dba10ccc358edd4b032021-11-17T11:10:20ZEstablishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis1001-5256https://doaj.org/article/921a7697879a42dba10ccc358edd4b032021-11-01T00:00:00Zhttp://www.lcgdbzz.org/cn/article/doi/10.3969/j.issn.1001-5256.2021.11.027https://doaj.org/toc/1001-5256ObjectiveTo establish a nomogram for predicting the risk of post-hepatectomy complications (PHC) in hepatic echinococcosis by analyzing the risk factors for PHC in two types of hepatic echinococcosis, and to investigate its value in clinical practice. MethodsA retrospective analysis was performed for the clinical data of 263 patients with two types of hepatic echinococcosis who underwent hepatectomy in Qinghai University Affiliated Hospital from January 2015 to August 2020, and among these patients, 93 were enrolled as PHC group and 170 were enrolled as control group. The Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups, and the independent samples t-test was used for comparison of normally distributed continuous data between two groups; the chi-square test and the Fisher’s exact test were used for comparison of categorical data between two groups. Univariate and multivariate logistic regression analyses were used to screen out independent risk factors for PHC, and a nomogram risk prediction model was established based on the weight of each independent risk factor. The Bootstrap resampling method was used for internal verification of the model; the receiver operating characteristic (ROC) curve was plotted to evaluate the discriminatory ability of the model; calibration curve and the Hosmer-Lemeshow test were used to evaluate the consistency of the model; decision curve analysis (DCA) was performed to verify the clinical effectiveness of the model. ResultsAlbumin-bilirubin (ALBI) score (odds ratio ［OR］=3.694, 95% confidence interval ［CI］: 1.860-7336, P＜0.05), time of operation (OR=2.848, 95%CI: 1.384-5.859, P＜0.05), intraoperative blood loss (OR=4.832, 95%CI: 2.384-9.793, P＜0.05), and hydatid diameter (OR=3.073, 95%CI: 1.528-6.177, P＜0.05) were independent risk factors for PHC in two types of hepatic echinococcosis. A nomogram risk prediction model was established based on the weight of the above four independent risk factors, and the model had an area under the ROC curve of 0.877 (95%CI: 0.831-0.923). The model had a consistency index of 0.871 after internal verification using the Bootstrap resampling method, suggesting that the model had good discriminatory ability. The fitting of the observed value and the actual value of the calibration curve and the Hosmer-Lemeshow test (P=0.905) showed that the predicted value of the nomogram risk prediction model had good consistency with the actual observed value. When the threshold probability was 35.6%, DCA showed a net clinical benefit of 22%, and the model had good clinical applicability within the threshold probability ranging from 8% to 89%. ConclusionALBI score, time of operation, intraoperative blood loss, and hydatid diameter are independent risk factors for PHC in patients with two types of hepatic echinococcosis, and the nomogram risk prediction model established based on these factors has good accuracy, consistency, and clinical practicability. GUO BingEditorial Department of Journal of Clinical HepatologyarticleDiseases of the digestive system. GastroenterologyRC799-869ZHLinchuang Gandanbing Zazhi, Vol 37, Iss 11, Pp 2626-2631 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Diseases of the digestive system. Gastroenterology RC799-869 GUO Bing Establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis
description	ObjectiveTo establish a nomogram for predicting the risk of post-hepatectomy complications (PHC) in hepatic echinococcosis by analyzing the risk factors for PHC in two types of hepatic echinococcosis, and to investigate its value in clinical practice. MethodsA retrospective analysis was performed for the clinical data of 263 patients with two types of hepatic echinococcosis who underwent hepatectomy in Qinghai University Affiliated Hospital from January 2015 to August 2020, and among these patients, 93 were enrolled as PHC group and 170 were enrolled as control group. The Mann-Whitney U test was used for comparison of non-normally distributed continuous data between two groups, and the independent samples t-test was used for comparison of normally distributed continuous data between two groups; the chi-square test and the Fisher’s exact test were used for comparison of categorical data between two groups. Univariate and multivariate logistic regression analyses were used to screen out independent risk factors for PHC, and a nomogram risk prediction model was established based on the weight of each independent risk factor. The Bootstrap resampling method was used for internal verification of the model; the receiver operating characteristic (ROC) curve was plotted to evaluate the discriminatory ability of the model; calibration curve and the Hosmer-Lemeshow test were used to evaluate the consistency of the model; decision curve analysis (DCA) was performed to verify the clinical effectiveness of the model. ResultsAlbumin-bilirubin (ALBI) score (odds ratio ［OR］=3.694, 95% confidence interval ［CI］: 1.860-7336, P＜0.05), time of operation (OR=2.848, 95%CI: 1.384-5.859, P＜0.05), intraoperative blood loss (OR=4.832, 95%CI: 2.384-9.793, P＜0.05), and hydatid diameter (OR=3.073, 95%CI: 1.528-6.177, P＜0.05) were independent risk factors for PHC in two types of hepatic echinococcosis. A nomogram risk prediction model was established based on the weight of the above four independent risk factors, and the model had an area under the ROC curve of 0.877 (95%CI: 0.831-0.923). The model had a consistency index of 0.871 after internal verification using the Bootstrap resampling method, suggesting that the model had good discriminatory ability. The fitting of the observed value and the actual value of the calibration curve and the Hosmer-Lemeshow test (P=0.905) showed that the predicted value of the nomogram risk prediction model had good consistency with the actual observed value. When the threshold probability was 35.6%, DCA showed a net clinical benefit of 22%, and the model had good clinical applicability within the threshold probability ranging from 8% to 89%. ConclusionALBI score, time of operation, intraoperative blood loss, and hydatid diameter are independent risk factors for PHC in patients with two types of hepatic echinococcosis, and the nomogram risk prediction model established based on these factors has good accuracy, consistency, and clinical practicability.
format	article
author	GUO Bing
author_facet	GUO Bing
author_sort	GUO Bing
title	Establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis
title_short	Establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis
title_full	Establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis
title_fullStr	Establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis
title_full_unstemmed	Establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis
title_sort	establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis
publisher	Editorial Department of Journal of Clinical Hepatology
publishDate	2021
url	https://doaj.org/article/921a7697879a42dba10ccc358edd4b03
work_keys_str_mv	AT guobing establishmentandevaluationofanomogramforpredictingposthepatectomycomplicationsintwotypesofhepaticechinococcosis
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Establishment and evaluation of a nomogram for predicting post-hepatectomy complications in two types of hepatic echinococcosis

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