Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation
Junsheng Fan,1,2,* Tszhei Fong,1,* Xinjie Chen,3,* Chuyun Chen,1 Peng Luo,1 Haiting Xie1 1Zhujiang Hospital of Southern Medical University, Guangzhou, China; 2Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China; 3Second School of Clinic Medicine, Guangzhou University of C...
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Dove Medical Press
2018
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oai:doaj.org-article:9224e38641db45f2a17c4ed69ddee0192021-12-02T04:00:37ZGlia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation1178-2021https://doaj.org/article/9224e38641db45f2a17c4ed69ddee0192018-02-01T00:00:00Zhttps://www.dovepress.com/glia-maturation-factor-beta-a-potential-therapeutic-target-in-neurodeg-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Junsheng Fan,1,2,* Tszhei Fong,1,* Xinjie Chen,3,* Chuyun Chen,1 Peng Luo,1 Haiting Xie1 1Zhujiang Hospital of Southern Medical University, Guangzhou, China; 2Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China; 3Second School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China *These authors contributed equally to this work Abstract: Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxide dismutase, granulocyte-macrophage colony-stimulating factor, and neurotrophin. In this review, we mainly discussed the role of GMFB in several neuroinflammatory and neurodegenerative diseases. On review of the literature, we propose that GMFB may be a promising therapeutic target for neuroinflammatory and neurodegenerative diseases. Keywords: glia maturation factor-β, neurodegeneration, neuroinflammationFan JFong TChen XChen CLuo PXie HDove Medical PressarticleGlia maturation factor-βneurodegenerationneuroinflammationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 495-504 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Glia maturation factor-β neurodegeneration neuroinflammation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Glia maturation factor-β neurodegeneration neuroinflammation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Fan J Fong T Chen X Chen C Luo P Xie H Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation |
| description |
Junsheng Fan,1,2,* Tszhei Fong,1,* Xinjie Chen,3,* Chuyun Chen,1 Peng Luo,1 Haiting Xie1 1Zhujiang Hospital of Southern Medical University, Guangzhou, China; 2Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China; 3Second School of Clinic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China *These authors contributed equally to this work Abstract: Glia maturation factor-β (GMFB) is considered to be a growth and differentiation factor for both glia and neurons. GMFB has been found to be upregulated in several neuroinflammation and neurodegeneration conditions. It may function by mediating apoptosis and by modulating the expression of superoxide dismutase, granulocyte-macrophage colony-stimulating factor, and neurotrophin. In this review, we mainly discussed the role of GMFB in several neuroinflammatory and neurodegenerative diseases. On review of the literature, we propose that GMFB may be a promising therapeutic target for neuroinflammatory and neurodegenerative diseases. Keywords: glia maturation factor-β, neurodegeneration, neuroinflammation |
| format |
article |
| author |
Fan J Fong T Chen X Chen C Luo P Xie H |
| author_facet |
Fan J Fong T Chen X Chen C Luo P Xie H |
| author_sort |
Fan J |
| title |
Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation |
| title_short |
Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation |
| title_full |
Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation |
| title_fullStr |
Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation |
| title_full_unstemmed |
Glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation |
| title_sort |
glia maturation factor-β: a potential therapeutic target in neurodegeneration and neuroinflammation |
| publisher |
Dove Medical Press |
| publishDate |
2018 |
| url |
https://doaj.org/article/9224e38641db45f2a17c4ed69ddee019 |
| work_keys_str_mv |
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1718401505114980352 |