Criticality in Cell Adhesion

We illuminate the many-body effects underlying the structure, formation, and dissolution of cellular adhesion domains in the presence and absence of forces. We consider mixed Glauber-Kawasaki dynamics of a two-dimensional model of nearest-neighbor-interacting adhesion bonds with intrinsic binding af...

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Autores principales:	Kristian Blom, Aljaž Godec
Formato:	article
Lenguaje:	EN
Publicado:	American Physical Society 2021
Materias:	Physics QC1-999
Acceso en línea:	https://doaj.org/article/9225222540784500b1ef162f16a6ef0b
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spelling	oai:doaj.org-article:9225222540784500b1ef162f16a6ef0b2021-12-02T15:13:51ZCriticality in Cell Adhesion10.1103/PhysRevX.11.0310672160-3308https://doaj.org/article/9225222540784500b1ef162f16a6ef0b2021-09-01T00:00:00Zhttp://doi.org/10.1103/PhysRevX.11.031067http://doi.org/10.1103/PhysRevX.11.031067https://doaj.org/toc/2160-3308We illuminate the many-body effects underlying the structure, formation, and dissolution of cellular adhesion domains in the presence and absence of forces. We consider mixed Glauber-Kawasaki dynamics of a two-dimensional model of nearest-neighbor-interacting adhesion bonds with intrinsic binding affinity under the action of a shared pulling or pushing force. We consider adhesion bonds that are immobile due to being anchored to the underlying cytoskeleton, as well as adhesion molecules that are transiently diffusing. Highly accurate analytical results are obtained on the pair-correlation level of the Bethe-Guggenheim approximation for the complete thermodynamics and kinetics of adhesion clusters of any size, including the thermodynamic limit. A new kind of dynamical phase transition is uncovered—the mean formation and dissolution times per adhesion bond change discontinuously with respect to the bond-coupling parameter. At the respective critical points, cluster formation and dissolution are the fastest, while the statistically dominant transition path undergoes a qualitative change—the entropic barrier to a completely bound or unbound state is rate-limiting below, and the phase transition between dense and dilute phases above the dynamical critical point. In the context of the Ising model, the dynamical phase transition reflects a first-order discontinuity in the magnetization-reversal time. Our results provide a potential explanation for the mechanical regulation of cell adhesion and suggest that the quasistatic and kinetic responses to changes in the membrane stiffness or applied forces is largest near the statical and dynamical critical points, respectively.Kristian BlomAljaž GodecAmerican Physical SocietyarticlePhysicsQC1-999ENPhysical Review X, Vol 11, Iss 3, p 031067 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Physics QC1-999
spellingShingle	Physics QC1-999 Kristian Blom Aljaž Godec Criticality in Cell Adhesion
description	We illuminate the many-body effects underlying the structure, formation, and dissolution of cellular adhesion domains in the presence and absence of forces. We consider mixed Glauber-Kawasaki dynamics of a two-dimensional model of nearest-neighbor-interacting adhesion bonds with intrinsic binding affinity under the action of a shared pulling or pushing force. We consider adhesion bonds that are immobile due to being anchored to the underlying cytoskeleton, as well as adhesion molecules that are transiently diffusing. Highly accurate analytical results are obtained on the pair-correlation level of the Bethe-Guggenheim approximation for the complete thermodynamics and kinetics of adhesion clusters of any size, including the thermodynamic limit. A new kind of dynamical phase transition is uncovered—the mean formation and dissolution times per adhesion bond change discontinuously with respect to the bond-coupling parameter. At the respective critical points, cluster formation and dissolution are the fastest, while the statistically dominant transition path undergoes a qualitative change—the entropic barrier to a completely bound or unbound state is rate-limiting below, and the phase transition between dense and dilute phases above the dynamical critical point. In the context of the Ising model, the dynamical phase transition reflects a first-order discontinuity in the magnetization-reversal time. Our results provide a potential explanation for the mechanical regulation of cell adhesion and suggest that the quasistatic and kinetic responses to changes in the membrane stiffness or applied forces is largest near the statical and dynamical critical points, respectively.
format	article
author	Kristian Blom Aljaž Godec
author_facet	Kristian Blom Aljaž Godec
author_sort	Kristian Blom
title	Criticality in Cell Adhesion
title_short	Criticality in Cell Adhesion
title_full	Criticality in Cell Adhesion
title_fullStr	Criticality in Cell Adhesion
title_full_unstemmed	Criticality in Cell Adhesion
title_sort	criticality in cell adhesion
publisher	American Physical Society
publishDate	2021
url	https://doaj.org/article/9225222540784500b1ef162f16a6ef0b
work_keys_str_mv	AT kristianblom criticalityincelladhesion AT aljazgodec criticalityincelladhesion
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Criticality in Cell Adhesion

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