Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.

This study builds on the findings that physical activity, such as wheel running in mice, enhances cell proliferation and neurogenesis in the adult hippocampus of the common mouse strain C57BL/6, and that the baseline level of neurogenesis varies by strain, being considerably lower in DBA/2. Because...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rupert W Overall, Tara L Walker, Odette Leiter, Sina Lenke, Susann Ruhwald, Gerd Kempermann
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92254176b7af4606918c6b3c33dca5c6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92254176b7af4606918c6b3c33dca5c6
record_format	dspace
spelling	oai:doaj.org-article:92254176b7af4606918c6b3c33dca5c62021-11-18T08:40:51ZDelayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.1932-620310.1371/journal.pone.0083797https://doaj.org/article/92254176b7af4606918c6b3c33dca5c62013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24376750/?tool=EBIhttps://doaj.org/toc/1932-6203This study builds on the findings that physical activity, such as wheel running in mice, enhances cell proliferation and neurogenesis in the adult hippocampus of the common mouse strain C57BL/6, and that the baseline level of neurogenesis varies by strain, being considerably lower in DBA/2. Because C57BL/6 and DBA/2 are important as the parental strains of the BXD recombinant inbred cross which allows the detection of genetic loci regulating phenotypes such as adult neurogenesis, we performed the current study to investigate the gene x environment interactions regulating neurogenesis. At equal distances and times run DBA/2J mice lacked the acute increase in precursor cell proliferation known from C57BL/6. In DBA/2J proliferation even negatively correlated with the distance run. This was neither due to a stress response (to running itself or single housing) nor differences in estrous cycle. DBA/2 animals exhibited a delayed and weaker pro-neurogenic response with a significant increase in numbers of proliferating cells first detectable after more than a week of wheel running. The proliferative response to running was transient in both strains, the effect being undetectable by 6 weeks. There was also a small transient increase in the production of new neurons in DBA/2J, although these extra cells did not survive. These findings indicate that the comparison between C57BL/6 and DBA/2, and by extension the BXD genetic reference population derived from these strains, should provide a powerful tool for uncovering the complex network of modifier genes affecting the activity-dependent regulation of adult hippocampal neurogenesis. More generally, our findings also describe how the external physical environment interacts with the internal genetic environment to produce different responses to the same behavioral stimuli.Rupert W OverallTara L WalkerOdette LeiterSina LenkeSusann RuhwaldGerd KempermannPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83797 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rupert W Overall Tara L Walker Odette Leiter Sina Lenke Susann Ruhwald Gerd Kempermann Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.
description	This study builds on the findings that physical activity, such as wheel running in mice, enhances cell proliferation and neurogenesis in the adult hippocampus of the common mouse strain C57BL/6, and that the baseline level of neurogenesis varies by strain, being considerably lower in DBA/2. Because C57BL/6 and DBA/2 are important as the parental strains of the BXD recombinant inbred cross which allows the detection of genetic loci regulating phenotypes such as adult neurogenesis, we performed the current study to investigate the gene x environment interactions regulating neurogenesis. At equal distances and times run DBA/2J mice lacked the acute increase in precursor cell proliferation known from C57BL/6. In DBA/2J proliferation even negatively correlated with the distance run. This was neither due to a stress response (to running itself or single housing) nor differences in estrous cycle. DBA/2 animals exhibited a delayed and weaker pro-neurogenic response with a significant increase in numbers of proliferating cells first detectable after more than a week of wheel running. The proliferative response to running was transient in both strains, the effect being undetectable by 6 weeks. There was also a small transient increase in the production of new neurons in DBA/2J, although these extra cells did not survive. These findings indicate that the comparison between C57BL/6 and DBA/2, and by extension the BXD genetic reference population derived from these strains, should provide a powerful tool for uncovering the complex network of modifier genes affecting the activity-dependent regulation of adult hippocampal neurogenesis. More generally, our findings also describe how the external physical environment interacts with the internal genetic environment to produce different responses to the same behavioral stimuli.
format	article
author	Rupert W Overall Tara L Walker Odette Leiter Sina Lenke Susann Ruhwald Gerd Kempermann
author_facet	Rupert W Overall Tara L Walker Odette Leiter Sina Lenke Susann Ruhwald Gerd Kempermann
author_sort	Rupert W Overall
title	Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.
title_short	Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.
title_full	Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.
title_fullStr	Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.
title_full_unstemmed	Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.
title_sort	delayed and transient increase of adult hippocampal neurogenesis by physical exercise in dba/2 mice.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/92254176b7af4606918c6b3c33dca5c6
work_keys_str_mv	AT rupertwoverall delayedandtransientincreaseofadulthippocampalneurogenesisbyphysicalexerciseindba2mice AT taralwalker delayedandtransientincreaseofadulthippocampalneurogenesisbyphysicalexerciseindba2mice AT odetteleiter delayedandtransientincreaseofadulthippocampalneurogenesisbyphysicalexerciseindba2mice AT sinalenke delayedandtransientincreaseofadulthippocampalneurogenesisbyphysicalexerciseindba2mice AT susannruhwald delayedandtransientincreaseofadulthippocampalneurogenesisbyphysicalexerciseindba2mice AT gerdkempermann delayedandtransientincreaseofadulthippocampalneurogenesisbyphysicalexerciseindba2mice
_version_	1718421458865094656

Delayed and transient increase of adult hippocampal neurogenesis by physical exercise in DBA/2 mice.

Ejemplares similares