Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity

Mohammed M Mehanna,1,2 Amina Tarek Mneimneh,2 Souraya Domiati,3 Ahmed N Allam4 1Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon; 3Department of Pha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mehanna MM, Mneimneh AT, Domiati S, Allam AN
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	gastric ulcer gastroprotection limonene orodispersible tablets self-nanoemulsifying system tadalafil Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/922ebb991d1e434cacf2454d06eafa1c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:922ebb991d1e434cacf2454d06eafa1c
record_format	dspace
spelling	oai:doaj.org-article:922ebb991d1e434cacf2454d06eafa1c2021-12-02T10:39:29ZTadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity1178-2013https://doaj.org/article/922ebb991d1e434cacf2454d06eafa1c2020-12-01T00:00:00Zhttps://www.dovepress.com/tadalafil-loaded-limonene-based-orodispersible-tablets-formulation-in--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohammed M Mehanna,1,2 Amina Tarek Mneimneh,2 Souraya Domiati,3 Ahmed N Allam4 1Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon; 3Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon; 4Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptCorrespondence: Mohammed M MehannaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonTel +961 71708661Email mmhanna@bau.edu.lbBackground: Gastric ulcer is a prevalent disease with various etiologies, including non-steroidal anti-inflammatory drugs and alcohol consumption. This study aimed to explore the dual gastric protection effect of tadalafil and limonene as a self-nanoemulsifying system (SNES)-based orodispersible tablets.Methods: Tadalafil-loaded limonene-based SNES was prepared, and the optimum formula was characterized in terms of particle size (PS), polydispersity index (PDI), and zeta potential (ZP) then loaded on various porous carriers to formulate lyophilized orodispersible tablets (ODTs). The ODTs were evaluated via determining hardness, friability, content uniformity, wetting, and disintegration time. The selected ODT was examined for its gastric ulcer protective effect against alcohol-induced ulcers in rat model. Ulcer score and ulcer index were computed for rats stomachs that were inspected macroscopically and histopathologically.Results: The prepared SNES had droplet size of 104 nm, polydispersity index of 0.2, and zeta potential of − 15.4 mV. From the different ODTs formulated, the formula with superior wetting time: 23.67 s, outstanding disintegration time: 28 s, accepted hardness value: 3.11 kg/cm2 and friability: 0.6% was designated. A significant gastroprotective effect of the unloaded and tadalafil-loaded ODTs was recognized compared to the omeprazole pre-treated group. Moreover, the histopathological analysis displayed very mild inflammation in the limonene-based ODTs group and intact structure in the tadalafil-loaded pre-treated animals.Conclusion: Limonene gastroprotective effect functioned along with tadalafil in the form of SNES-incorporated ODTs could serve as a promising revenue for better efficacy in gastric ulcer prevention.Keywords: gastric ulcer, gastroprotection, limonene, orodispersible tablets, self-nanoemulsifying system, tadalafilMehanna MMMneimneh ATDomiati SAllam ANDove Medical Pressarticlegastric ulcergastroprotectionlimoneneorodispersible tabletsself-nanoemulsifying systemtadalafilMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 10099-10112 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric ulcer gastroprotection limonene orodispersible tablets self-nanoemulsifying system tadalafil Medicine (General) R5-920
spellingShingle	gastric ulcer gastroprotection limonene orodispersible tablets self-nanoemulsifying system tadalafil Medicine (General) R5-920 Mehanna MM Mneimneh AT Domiati S Allam AN Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity
description	Mohammed M Mehanna,1,2 Amina Tarek Mneimneh,2 Souraya Domiati,3 Ahmed N Allam4 1Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt; 2Department of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon; 3Department of Pharmacology and Therapeutics, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon; 4Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, EgyptCorrespondence: Mohammed M MehannaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, LebanonTel +961 71708661Email mmhanna@bau.edu.lbBackground: Gastric ulcer is a prevalent disease with various etiologies, including non-steroidal anti-inflammatory drugs and alcohol consumption. This study aimed to explore the dual gastric protection effect of tadalafil and limonene as a self-nanoemulsifying system (SNES)-based orodispersible tablets.Methods: Tadalafil-loaded limonene-based SNES was prepared, and the optimum formula was characterized in terms of particle size (PS), polydispersity index (PDI), and zeta potential (ZP) then loaded on various porous carriers to formulate lyophilized orodispersible tablets (ODTs). The ODTs were evaluated via determining hardness, friability, content uniformity, wetting, and disintegration time. The selected ODT was examined for its gastric ulcer protective effect against alcohol-induced ulcers in rat model. Ulcer score and ulcer index were computed for rats stomachs that were inspected macroscopically and histopathologically.Results: The prepared SNES had droplet size of 104 nm, polydispersity index of 0.2, and zeta potential of − 15.4 mV. From the different ODTs formulated, the formula with superior wetting time: 23.67 s, outstanding disintegration time: 28 s, accepted hardness value: 3.11 kg/cm2 and friability: 0.6% was designated. A significant gastroprotective effect of the unloaded and tadalafil-loaded ODTs was recognized compared to the omeprazole pre-treated group. Moreover, the histopathological analysis displayed very mild inflammation in the limonene-based ODTs group and intact structure in the tadalafil-loaded pre-treated animals.Conclusion: Limonene gastroprotective effect functioned along with tadalafil in the form of SNES-incorporated ODTs could serve as a promising revenue for better efficacy in gastric ulcer prevention.Keywords: gastric ulcer, gastroprotection, limonene, orodispersible tablets, self-nanoemulsifying system, tadalafil
format	article
author	Mehanna MM Mneimneh AT Domiati S Allam AN
author_facet	Mehanna MM Mneimneh AT Domiati S Allam AN
author_sort	Mehanna MM
title	Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity
title_short	Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity
title_full	Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity
title_fullStr	Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity
title_full_unstemmed	Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity
title_sort	tadalafil-loaded limonene-based orodispersible tablets: formulation, in vitro characterization and in vivo appraisal of gastroprotective activity
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/922ebb991d1e434cacf2454d06eafa1c
work_keys_str_mv	AT mehannamm tadalafilloadedlimonenebasedorodispersibletabletsformulationinvitrocharacterizationandinvivoappraisalofgastroprotectiveactivity AT mneimnehat tadalafilloadedlimonenebasedorodispersibletabletsformulationinvitrocharacterizationandinvivoappraisalofgastroprotectiveactivity AT domiatis tadalafilloadedlimonenebasedorodispersibletabletsformulationinvitrocharacterizationandinvivoappraisalofgastroprotectiveactivity AT allaman tadalafilloadedlimonenebasedorodispersibletabletsformulationinvitrocharacterizationandinvivoappraisalofgastroprotectiveactivity
_version_	1718396893734633472

Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity

Ejemplares similares