Hypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats

Dagninet Derebe,1 Muluken Wubetu,2 Amare Alamirew1 1Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia; 2Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Dagninet Derebe Email da...

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Autores principales:	Derebe D, Wubetu M, Alamirew A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	acanthus polystachyus antihyperglycemic type 2 diabetes streptozotocin nicotinamide Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/9231d749e01f4968819c6a31ca7f4d96
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spelling	oai:doaj.org-article:9231d749e01f4968819c6a31ca7f4d962021-12-02T13:04:02ZHypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats1179-1438https://doaj.org/article/9231d749e01f4968819c6a31ca7f4d962020-09-01T00:00:00Zhttps://www.dovepress.com/hypoglycemic-and-antihyperglycemic-activities-of-80-methanol-root-extr-peer-reviewed-article-CPAAhttps://doaj.org/toc/1179-1438Dagninet Derebe,1 Muluken Wubetu,2 Amare Alamirew1 1Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia; 2Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Dagninet Derebe Email dagninet37@yahoo.comBackground: The morbidity and mortality rate from diabetic mellitus are increasing in the world especially in low- and middle-income countries; hence, it is necessary to evaluate the efficacy and safety of medicinal plants to support existing drugs in treating diabetes mellitus. Therefore, the aim of this study was to evaluate the hypoglycemic effect of 80% methanol root extract of Acanthus polystachyus in normoglycemic, hyperglycemic, and streptozotocin–nicotinamide induced diabetic rats.Methods: Male albino Wistar rats were divided into five groups (n=6) in all three models. In all models, group one rats served as a negative control and were received vehicle (10mL/kg distilled water), whereas group two (APRE100), three (APRE200), and four (APRE400) were treated with 100, 200, and 400mg/kg of extract, respectively, and group five were treated with glibenclamide (5mg/kg) and served as a positive control. Blood glucose levels were measured at different time points by taking blood from their tails. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test to carry out comparisons between and within-group and P < 0.05 was considered as statistically significant.Results: The root of Acanthus polystachyus reduces peak blood sugar levels significantly after the loading of oral glucose at all tested doses. In streptozotocin–nicotinamide-induced type 2 diabetic rats, the daily oral administration of the crude extracts showed a significant reduction of blood glucose level at all tested doses compared to the negative control group. However, the extract did not reduce blood glucose levels in normoglycemic rats at all tested doses compared to both negative and positive control.Conclusion: From this study, it can be concluded that the root extract of Acanthus polystachyus showed an antihyperglycemic effect in hyperglycemic and diabetic rats but lack hypoglycemic effect in normoglycemic rats. Hence, the plant root may be a good candidate for the development of new antidiabetic drugs.Keywords: Acanthus polystachyus, antihyperglycemic, type 2 diabetes, streptozotocin, nicotinamideDerebe DWubetu MAlamirew ADove Medical Pressarticleacanthus polystachyusantihyperglycemictype 2 diabetesstreptozotocinnicotinamideTherapeutics. PharmacologyRM1-950ENClinical Pharmacology: Advances and Applications, Vol Volume 12, Pp 149-157 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	acanthus polystachyus antihyperglycemic type 2 diabetes streptozotocin nicotinamide Therapeutics. Pharmacology RM1-950
spellingShingle	acanthus polystachyus antihyperglycemic type 2 diabetes streptozotocin nicotinamide Therapeutics. Pharmacology RM1-950 Derebe D Wubetu M Alamirew A Hypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats
description	Dagninet Derebe,1 Muluken Wubetu,2 Amare Alamirew1 1Department of Pharmacy, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia; 2Department of Pharmacy, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaCorrespondence: Dagninet Derebe Email dagninet37@yahoo.comBackground: The morbidity and mortality rate from diabetic mellitus are increasing in the world especially in low- and middle-income countries; hence, it is necessary to evaluate the efficacy and safety of medicinal plants to support existing drugs in treating diabetes mellitus. Therefore, the aim of this study was to evaluate the hypoglycemic effect of 80% methanol root extract of Acanthus polystachyus in normoglycemic, hyperglycemic, and streptozotocin–nicotinamide induced diabetic rats.Methods: Male albino Wistar rats were divided into five groups (n=6) in all three models. In all models, group one rats served as a negative control and were received vehicle (10mL/kg distilled water), whereas group two (APRE100), three (APRE200), and four (APRE400) were treated with 100, 200, and 400mg/kg of extract, respectively, and group five were treated with glibenclamide (5mg/kg) and served as a positive control. Blood glucose levels were measured at different time points by taking blood from their tails. Data were analyzed using one-way ANOVA followed by Tukey’s post hoc test to carry out comparisons between and within-group and P < 0.05 was considered as statistically significant.Results: The root of Acanthus polystachyus reduces peak blood sugar levels significantly after the loading of oral glucose at all tested doses. In streptozotocin–nicotinamide-induced type 2 diabetic rats, the daily oral administration of the crude extracts showed a significant reduction of blood glucose level at all tested doses compared to the negative control group. However, the extract did not reduce blood glucose levels in normoglycemic rats at all tested doses compared to both negative and positive control.Conclusion: From this study, it can be concluded that the root extract of Acanthus polystachyus showed an antihyperglycemic effect in hyperglycemic and diabetic rats but lack hypoglycemic effect in normoglycemic rats. Hence, the plant root may be a good candidate for the development of new antidiabetic drugs.Keywords: Acanthus polystachyus, antihyperglycemic, type 2 diabetes, streptozotocin, nicotinamide
format	article
author	Derebe D Wubetu M Alamirew A
author_facet	Derebe D Wubetu M Alamirew A
author_sort	Derebe D
title	Hypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats
title_short	Hypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats
title_full	Hypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats
title_fullStr	Hypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats
title_full_unstemmed	Hypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats
title_sort	hypoglycemic and antihyperglycemic activities of 80% methanol root extract of acanthus polystachyus delile (acanthaceae) in type 2 diabetic rats
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/9231d749e01f4968819c6a31ca7f4d96
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Hypoglycemic and Antihyperglycemic Activities of 80% Methanol Root Extract of Acanthus polystachyus Delile (Acanthaceae) in Type 2 Diabetic Rats

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