BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.

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Autores principales:	Antoine Campagne, Ming-Kang Lee, Dina Zielinski, Audrey Michaud, Stéphanie Le Corre, Florent Dingli, Hong Chen, Lara Z. Shahidian, Ivaylo Vassilev, Nicolas Servant, Damarys Loew, Eric Pasmant, Sophie Postel-Vinay, Michel Wassef, Raphaël Margueron
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92338fdb37b04b3b97a5b2deb5e4d404
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spelling	oai:doaj.org-article:92338fdb37b04b3b97a5b2deb5e4d4042021-12-02T16:58:02ZBAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation10.1038/s41467-018-08255-x2041-1723https://doaj.org/article/92338fdb37b04b3b97a5b2deb5e4d4042019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08255-xhttps://doaj.org/toc/2041-1723In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.Antoine CampagneMing-Kang LeeDina ZielinskiAudrey MichaudStéphanie Le CorreFlorent DingliHong ChenLara Z. ShahidianIvaylo VassilevNicolas ServantDamarys LoewEric PasmantSophie Postel-VinayMichel WassefRaphaël MargueronNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Antoine Campagne Ming-Kang Lee Dina Zielinski Audrey Michaud Stéphanie Le Corre Florent Dingli Hong Chen Lara Z. Shahidian Ivaylo Vassilev Nicolas Servant Damarys Loew Eric Pasmant Sophie Postel-Vinay Michel Wassef Raphaël Margueron BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
description	In Drosophila, the Calypso–ASX complex catalyzes H2A deubiquitination and aids Polycomb in transcriptional silencing. Here the authors show that the orthologous complex, BAP1.com, promotes gene activation by counteracting PRC1-mediated gene silencing.
format	article
author	Antoine Campagne Ming-Kang Lee Dina Zielinski Audrey Michaud Stéphanie Le Corre Florent Dingli Hong Chen Lara Z. Shahidian Ivaylo Vassilev Nicolas Servant Damarys Loew Eric Pasmant Sophie Postel-Vinay Michel Wassef Raphaël Margueron
author_facet	Antoine Campagne Ming-Kang Lee Dina Zielinski Audrey Michaud Stéphanie Le Corre Florent Dingli Hong Chen Lara Z. Shahidian Ivaylo Vassilev Nicolas Servant Damarys Loew Eric Pasmant Sophie Postel-Vinay Michel Wassef Raphaël Margueron
author_sort	Antoine Campagne
title	BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
title_short	BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
title_full	BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
title_fullStr	BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
title_full_unstemmed	BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation
title_sort	bap1 complex promotes transcription by opposing prc1-mediated h2a ubiquitylation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/92338fdb37b04b3b97a5b2deb5e4d404
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BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation

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