Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats

Qiong Wu,1,2,* Yu Cao,1,* Meixia Liu,1 Fang Liu,1 Adelheid H Brantner,3 Yang Yang,1 Yun Wei,1 Yu Zhou,4 Zhiyong Wang,1 Lina Ma,1 Feixue Wang,1 Hui Pei,1 Hao Li1 1Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, People’s Republic of China...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wu Q, Cao Y, Liu M, Liu F, Brantner AH, Yang Y, Wei Y, Zhou Y, Wang Z, Ma L, Wang F, Pei H, Li H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	dementia shenmayizhi decoction scopolamine acetylcholine m1 receptor acetylcholinesterase cholineacetyltransferase Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/923397c1f4524f8bbd51f4a0e39cb570
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:923397c1f4524f8bbd51f4a0e39cb570
record_format	dspace
spelling	oai:doaj.org-article:923397c1f4524f8bbd51f4a0e39cb5702021-12-02T07:52:30ZTraditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats1178-2021https://doaj.org/article/923397c1f4524f8bbd51f4a0e39cb5702019-11-01T00:00:00Zhttps://www.dovepress.com/traditional-chinese-medicine-shenmayizhi-decoction-ameliorates-memory--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Qiong Wu,1,2,* Yu Cao,1,* Meixia Liu,1 Fang Liu,1 Adelheid H Brantner,3 Yang Yang,1 Yun Wei,1 Yu Zhou,4 Zhiyong Wang,1 Lina Ma,1 Feixue Wang,1 Hui Pei,1 Hao Li1 1Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, People’s Republic of China; 2Department of Ophthalmology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, People’s Republic of China; 3Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria; 4Department of Polymer Chemistry, Zernike Institute for Advanced Materials, Groningen 9747 AG, The Netherlands*These authors contributed equally to this workCorrespondence: Hao Li; Hui PeiDepartment of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, 1 Xiyuan Caochang Road, Haidian District, Beijing 100091, People’s Republic of ChinaTel +86 10 6283 5631Email xyhplihao1965@126.com; phxydoctor@126.comPurpose: Clinical trials have illustrated that Shenmayizhi decoction (SMYZ) could improve the cognitive functions in patients with dementia. However, the mechanism needs to be explored.Methods: Fifty adult male rats (Wistar strain) were divided into five groups equally and randomly, including control, model, and SMYZ of low dose, medium dose and high dose. Rats in each group received a daily gavage of respective treatment. Rats in control and model group were administrated by the same volume of distilled water. Memory impairment was induced by intraperitoneal administration of scopolamine (0.7 mg/kg) for 5 continuous days. Four weeks later, Morris water maze (MWM) was performed to evaluate the spatial memory in all rats. Then, rats were sacrificed and the hippocampus was removed for further tests. Furthermore, Western blot analysis was employed to assess the levels of acetylcholine M1 receptor (M1), acetylcholine M2 receptor (M2), acetylcholinesterase (AChE) and cholineacetyltransferase (ChAT). AChE and ChAT activities were determined.Results: The SMYZ decoction significantly improved behavioral performance of rats in high dose. The SMYZ decoction in three doses exhibited anti-acetylcholinesterase activity. In addition, a high dose of SMYZ promoted ChAT activity. Moreover, a high dose of SMYZ increased the level of ChAT and declined the level of AChE assessed by Western blotting. Besides, an increased level of M1 receptor was found after treatment.Conclusion: Shenmayizhi decoction could mitigate scopolamine-induced cognitive deficits through the preventative effect on cholinergic system dysfunction.Keywords: dementia, Shenmayizhi decoction, scopolamine, acetylcholine M1 receptor, acetylcholinesterase, cholineacetyltransferase  Wu QCao YLiu MLiu FBrantner AHYang YWei YZhou YWang ZMa LWang FPei HLi HDove Medical Pressarticledementiashenmayizhi decoctionscopolamineacetylcholine m1 receptoracetylcholinesterasecholineacetyltransferaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3167-3176 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	dementia shenmayizhi decoction scopolamine acetylcholine m1 receptor acetylcholinesterase cholineacetyltransferase Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	dementia shenmayizhi decoction scopolamine acetylcholine m1 receptor acetylcholinesterase cholineacetyltransferase Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wu Q Cao Y Liu M Liu F Brantner AH Yang Y Wei Y Zhou Y Wang Z Ma L Wang F Pei H Li H Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats
description	Qiong Wu,1,2,* Yu Cao,1,* Meixia Liu,1 Fang Liu,1 Adelheid H Brantner,3 Yang Yang,1 Yun Wei,1 Yu Zhou,4 Zhiyong Wang,1 Lina Ma,1 Feixue Wang,1 Hui Pei,1 Hao Li1 1Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, People’s Republic of China; 2Department of Ophthalmology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, People’s Republic of China; 3Department of Pharmacognosy, Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria; 4Department of Polymer Chemistry, Zernike Institute for Advanced Materials, Groningen 9747 AG, The Netherlands*These authors contributed equally to this workCorrespondence: Hao Li; Hui PeiDepartment of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, 1 Xiyuan Caochang Road, Haidian District, Beijing 100091, People’s Republic of ChinaTel +86 10 6283 5631Email xyhplihao1965@126.com; phxydoctor@126.comPurpose: Clinical trials have illustrated that Shenmayizhi decoction (SMYZ) could improve the cognitive functions in patients with dementia. However, the mechanism needs to be explored.Methods: Fifty adult male rats (Wistar strain) were divided into five groups equally and randomly, including control, model, and SMYZ of low dose, medium dose and high dose. Rats in each group received a daily gavage of respective treatment. Rats in control and model group were administrated by the same volume of distilled water. Memory impairment was induced by intraperitoneal administration of scopolamine (0.7 mg/kg) for 5 continuous days. Four weeks later, Morris water maze (MWM) was performed to evaluate the spatial memory in all rats. Then, rats were sacrificed and the hippocampus was removed for further tests. Furthermore, Western blot analysis was employed to assess the levels of acetylcholine M1 receptor (M1), acetylcholine M2 receptor (M2), acetylcholinesterase (AChE) and cholineacetyltransferase (ChAT). AChE and ChAT activities were determined.Results: The SMYZ decoction significantly improved behavioral performance of rats in high dose. The SMYZ decoction in three doses exhibited anti-acetylcholinesterase activity. In addition, a high dose of SMYZ promoted ChAT activity. Moreover, a high dose of SMYZ increased the level of ChAT and declined the level of AChE assessed by Western blotting. Besides, an increased level of M1 receptor was found after treatment.Conclusion: Shenmayizhi decoction could mitigate scopolamine-induced cognitive deficits through the preventative effect on cholinergic system dysfunction.Keywords: dementia, Shenmayizhi decoction, scopolamine, acetylcholine M1 receptor, acetylcholinesterase, cholineacetyltransferase
format	article
author	Wu Q Cao Y Liu M Liu F Brantner AH Yang Y Wei Y Zhou Y Wang Z Ma L Wang F Pei H Li H
author_facet	Wu Q Cao Y Liu M Liu F Brantner AH Yang Y Wei Y Zhou Y Wang Z Ma L Wang F Pei H Li H
author_sort	Wu Q
title	Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats
title_short	Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats
title_full	Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats
title_fullStr	Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats
title_full_unstemmed	Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats
title_sort	traditional chinese medicine shenmayizhi decoction ameliorates memory and cognitive impairment induced by scopolamine via preventing hippocampal cholinergic dysfunction in rats
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/923397c1f4524f8bbd51f4a0e39cb570
work_keys_str_mv	AT wuq traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT caoy traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT lium traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT liuf traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT brantnerah traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT yangy traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT weiy traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT zhouy traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT wangz traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT mal traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT wangf traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT peih traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats AT lih traditionalchinesemedicineshenmayizhidecoctionamelioratesmemoryandcognitiveimpairmentinducedbyscopolamineviapreventinghippocampalcholinergicdysfunctioninrats
_version_	1718399114145693696

Traditional Chinese Medicine Shenmayizhi Decoction Ameliorates Memory And Cognitive Impairment Induced By Scopolamine Via Preventing Hippocampal Cholinergic Dysfunction In Rats

Ejemplares similares