Evidence of Neuroinflammation and Blood–Brain Barrier Disruption in Women with Preeclampsia and Eclampsia

Cerebral complications in preeclampsia are leading causes of maternal mortality. Animal models suggest that an injured blood–brain barrier and neuroinflammation may be important but there is paucity of data from human studies. Therefore, we aimed to evaluate this in women with preeclampsia and eclam...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lina Bergman, Roxanne Hastie, Henrik Zetterberg, Kaj Blennow, Sonja Schell, Eduard Langenegger, Ashley Moodley, Susan Walker, Stephen Tong, Catherine Cluver
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	eclampsia neuroinflammation blood–brain barrier preeclampsia cerebral edema Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/923867bdd6904e39ba13bebdd442be98
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:923867bdd6904e39ba13bebdd442be98
record_format	dspace
spelling	oai:doaj.org-article:923867bdd6904e39ba13bebdd442be982021-11-25T17:10:45ZEvidence of Neuroinflammation and Blood–Brain Barrier Disruption in Women with Preeclampsia and Eclampsia10.3390/cells101130452073-4409https://doaj.org/article/923867bdd6904e39ba13bebdd442be982021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3045https://doaj.org/toc/2073-4409Cerebral complications in preeclampsia are leading causes of maternal mortality. Animal models suggest that an injured blood–brain barrier and neuroinflammation may be important but there is paucity of data from human studies. Therefore, we aimed to evaluate this in women with preeclampsia and eclampsia. We included women recruited to the South African Preeclampsia Obstetric Adverse Events (PROVE) biobank. Blood and cerebrospinal fluid (CSF) were collected around delivery. CSF was analyzed for neuroinflammatory markers interleukin 1β, interleukin 6, interleukin-8 and tumor necrosis factor alpha (TNF-alpha). The CSF to plasma albumin ratio was measured to assess blood–brain barrier function. Women with eclampsia (<i>n</i> = 4) showed increased CSF concentrations of all pro-inflammatory cytokines and TNF-alpha compared to women with normotensive pregnancies (<i>n</i> = 7) and also for interleukin-6 and TNF-alpha compared to women with preeclampsia (<i>n</i> = 4). Women with preeclampsia also showed increases in pro-inflammatory cytokines IL-6 and IL-8 but not TNF-alpha in the CSF compared to women with normotensive pregnancies. In particular, women with eclampsia but also women with preeclampsia showed an increase in the CSF to plasma albumin ratio compared to normotensive women. In conclusion, women with preeclampsia and eclampsia show evidence of neuroinflammation and an injured blood–brain barrier. These findings are seen in particular among women with eclampsia.Lina BergmanRoxanne HastieHenrik ZetterbergKaj BlennowSonja SchellEduard LangeneggerAshley MoodleySusan WalkerStephen TongCatherine CluverMDPI AGarticleeclampsianeuroinflammationblood–brain barrierpreeclampsiacerebral edemaBiology (General)QH301-705.5ENCells, Vol 10, Iss 3045, p 3045 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	eclampsia neuroinflammation blood–brain barrier preeclampsia cerebral edema Biology (General) QH301-705.5
spellingShingle	eclampsia neuroinflammation blood–brain barrier preeclampsia cerebral edema Biology (General) QH301-705.5 Lina Bergman Roxanne Hastie Henrik Zetterberg Kaj Blennow Sonja Schell Eduard Langenegger Ashley Moodley Susan Walker Stephen Tong Catherine Cluver Evidence of Neuroinflammation and Blood–Brain Barrier Disruption in Women with Preeclampsia and Eclampsia
description	Cerebral complications in preeclampsia are leading causes of maternal mortality. Animal models suggest that an injured blood–brain barrier and neuroinflammation may be important but there is paucity of data from human studies. Therefore, we aimed to evaluate this in women with preeclampsia and eclampsia. We included women recruited to the South African Preeclampsia Obstetric Adverse Events (PROVE) biobank. Blood and cerebrospinal fluid (CSF) were collected around delivery. CSF was analyzed for neuroinflammatory markers interleukin 1β, interleukin 6, interleukin-8 and tumor necrosis factor alpha (TNF-alpha). The CSF to plasma albumin ratio was measured to assess blood–brain barrier function. Women with eclampsia (<i>n</i> = 4) showed increased CSF concentrations of all pro-inflammatory cytokines and TNF-alpha compared to women with normotensive pregnancies (<i>n</i> = 7) and also for interleukin-6 and TNF-alpha compared to women with preeclampsia (<i>n</i> = 4). Women with preeclampsia also showed increases in pro-inflammatory cytokines IL-6 and IL-8 but not TNF-alpha in the CSF compared to women with normotensive pregnancies. In particular, women with eclampsia but also women with preeclampsia showed an increase in the CSF to plasma albumin ratio compared to normotensive women. In conclusion, women with preeclampsia and eclampsia show evidence of neuroinflammation and an injured blood–brain barrier. These findings are seen in particular among women with eclampsia.
format	article
author	Lina Bergman Roxanne Hastie Henrik Zetterberg Kaj Blennow Sonja Schell Eduard Langenegger Ashley Moodley Susan Walker Stephen Tong Catherine Cluver
author_facet	Lina Bergman Roxanne Hastie Henrik Zetterberg Kaj Blennow Sonja Schell Eduard Langenegger Ashley Moodley Susan Walker Stephen Tong Catherine Cluver
author_sort	Lina Bergman
title	Evidence of Neuroinflammation and Blood–Brain Barrier Disruption in Women with Preeclampsia and Eclampsia
title_short	Evidence of Neuroinflammation and Blood–Brain Barrier Disruption in Women with Preeclampsia and Eclampsia
title_full	Evidence of Neuroinflammation and Blood–Brain Barrier Disruption in Women with Preeclampsia and Eclampsia
title_fullStr	Evidence of Neuroinflammation and Blood–Brain Barrier Disruption in Women with Preeclampsia and Eclampsia
title_full_unstemmed	Evidence of Neuroinflammation and Blood–Brain Barrier Disruption in Women with Preeclampsia and Eclampsia
title_sort	evidence of neuroinflammation and blood–brain barrier disruption in women with preeclampsia and eclampsia
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/923867bdd6904e39ba13bebdd442be98
work_keys_str_mv	AT linabergman evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia AT roxannehastie evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia AT henrikzetterberg evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia AT kajblennow evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia AT sonjaschell evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia AT eduardlangenegger evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia AT ashleymoodley evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia AT susanwalker evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia AT stephentong evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia AT catherinecluver evidenceofneuroinflammationandbloodbrainbarrierdisruptioninwomenwithpreeclampsiaandeclampsia
_version_	1718412665847545856

Evidence of Neuroinflammation and Blood–Brain Barrier Disruption in Women with Preeclampsia and Eclampsia

Ejemplares similares