Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells

Here, the authors characterize replication of SARS-CoV-2 in human airway epithelial (HAE) cultures and show that it can infect ciliated and secretory cells, affects transepithelial electrical resistance and causes plaque-like cytopathic effects associated with apoptosis.

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Autores principales: Na Zhu, Wenling Wang, Zhidong Liu, Chaoyang Liang, Wen Wang, Fei Ye, Baoying Huang, Li Zhao, Huijuan Wang, Weimin Zhou, Yao Deng, Longfei Mao, Chongyu Su, Guangliang Qiang, Taijiao Jiang, Jincun Zhao, Guizhen Wu, Jingdong Song, Wenjie Tan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Q
Acceso en línea:https://doaj.org/article/924009ffe59847a080b09c878a22d0d3
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spelling oai:doaj.org-article:924009ffe59847a080b09c878a22d0d32021-12-02T17:06:12ZMorphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells10.1038/s41467-020-17796-z2041-1723https://doaj.org/article/924009ffe59847a080b09c878a22d0d32020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17796-zhttps://doaj.org/toc/2041-1723Here, the authors characterize replication of SARS-CoV-2 in human airway epithelial (HAE) cultures and show that it can infect ciliated and secretory cells, affects transepithelial electrical resistance and causes plaque-like cytopathic effects associated with apoptosis.Na ZhuWenling WangZhidong LiuChaoyang LiangWen WangFei YeBaoying HuangLi ZhaoHuijuan WangWeimin ZhouYao DengLongfei MaoChongyu SuGuangliang QiangTaijiao JiangJincun ZhaoGuizhen WuJingdong SongWenjie TanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Na Zhu
Wenling Wang
Zhidong Liu
Chaoyang Liang
Wen Wang
Fei Ye
Baoying Huang
Li Zhao
Huijuan Wang
Weimin Zhou
Yao Deng
Longfei Mao
Chongyu Su
Guangliang Qiang
Taijiao Jiang
Jincun Zhao
Guizhen Wu
Jingdong Song
Wenjie Tan
Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
description Here, the authors characterize replication of SARS-CoV-2 in human airway epithelial (HAE) cultures and show that it can infect ciliated and secretory cells, affects transepithelial electrical resistance and causes plaque-like cytopathic effects associated with apoptosis.
format article
author Na Zhu
Wenling Wang
Zhidong Liu
Chaoyang Liang
Wen Wang
Fei Ye
Baoying Huang
Li Zhao
Huijuan Wang
Weimin Zhou
Yao Deng
Longfei Mao
Chongyu Su
Guangliang Qiang
Taijiao Jiang
Jincun Zhao
Guizhen Wu
Jingdong Song
Wenjie Tan
author_facet Na Zhu
Wenling Wang
Zhidong Liu
Chaoyang Liang
Wen Wang
Fei Ye
Baoying Huang
Li Zhao
Huijuan Wang
Weimin Zhou
Yao Deng
Longfei Mao
Chongyu Su
Guangliang Qiang
Taijiao Jiang
Jincun Zhao
Guizhen Wu
Jingdong Song
Wenjie Tan
author_sort Na Zhu
title Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
title_short Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
title_full Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
title_fullStr Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
title_full_unstemmed Morphogenesis and cytopathic effect of SARS-CoV-2 infection in human airway epithelial cells
title_sort morphogenesis and cytopathic effect of sars-cov-2 infection in human airway epithelial cells
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/924009ffe59847a080b09c878a22d0d3
work_keys_str_mv AT nazhu morphogenesisandcytopathiceffectofsarscov2infectioninhumanairwayepithelialcells
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