Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis

Dopamine dysregulation is centrally linked to major psychosis. Here, the authors characterise the hypomethylation of an enhancer within the insulin-like growth factor 2 gene in neurons of patients with major psychosis and provide evidence that this enhancer targets the tyrosine hydroxylase gene, res...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Shraddha Pai, Peipei Li, Bryan Killinger, Lee Marshall, Peixin Jia, Ji Liao, Arturas Petronis, Piroska E. Szabó, Viviane Labrie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92406a1645fa465a86fc451c78740010
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:92406a1645fa465a86fc451c78740010
record_format	dspace
spelling	oai:doaj.org-article:92406a1645fa465a86fc451c787400102021-12-02T17:02:00ZDifferential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis10.1038/s41467-019-09786-72041-1723https://doaj.org/article/92406a1645fa465a86fc451c787400102019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09786-7https://doaj.org/toc/2041-1723Dopamine dysregulation is centrally linked to major psychosis. Here, the authors characterise the hypomethylation of an enhancer within the insulin-like growth factor 2 gene in neurons of patients with major psychosis and provide evidence that this enhancer targets the tyrosine hydroxylase gene, responsible for dopamine synthesis.Shraddha PaiPeipei LiBryan KillingerLee MarshallPeixin JiaJi LiaoArturas PetronisPiroska E. SzabóViviane LabrieNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shraddha Pai Peipei Li Bryan Killinger Lee Marshall Peixin Jia Ji Liao Arturas Petronis Piroska E. Szabó Viviane Labrie Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
description	Dopamine dysregulation is centrally linked to major psychosis. Here, the authors characterise the hypomethylation of an enhancer within the insulin-like growth factor 2 gene in neurons of patients with major psychosis and provide evidence that this enhancer targets the tyrosine hydroxylase gene, responsible for dopamine synthesis.
format	article
author	Shraddha Pai Peipei Li Bryan Killinger Lee Marshall Peixin Jia Ji Liao Arturas Petronis Piroska E. Szabó Viviane Labrie
author_facet	Shraddha Pai Peipei Li Bryan Killinger Lee Marshall Peixin Jia Ji Liao Arturas Petronis Piroska E. Szabó Viviane Labrie
author_sort	Shraddha Pai
title	Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
title_short	Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
title_full	Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
title_fullStr	Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
title_full_unstemmed	Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis
title_sort	differential methylation of enhancer at igf2 is associated with abnormal dopamine synthesis in major psychosis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/92406a1645fa465a86fc451c78740010
work_keys_str_mv	AT shraddhapai differentialmethylationofenhanceratigf2isassociatedwithabnormaldopaminesynthesisinmajorpsychosis AT peipeili differentialmethylationofenhanceratigf2isassociatedwithabnormaldopaminesynthesisinmajorpsychosis AT bryankillinger differentialmethylationofenhanceratigf2isassociatedwithabnormaldopaminesynthesisinmajorpsychosis AT leemarshall differentialmethylationofenhanceratigf2isassociatedwithabnormaldopaminesynthesisinmajorpsychosis AT peixinjia differentialmethylationofenhanceratigf2isassociatedwithabnormaldopaminesynthesisinmajorpsychosis AT jiliao differentialmethylationofenhanceratigf2isassociatedwithabnormaldopaminesynthesisinmajorpsychosis AT arturaspetronis differentialmethylationofenhanceratigf2isassociatedwithabnormaldopaminesynthesisinmajorpsychosis AT piroskaeszabo differentialmethylationofenhanceratigf2isassociatedwithabnormaldopaminesynthesisinmajorpsychosis AT vivianelabrie differentialmethylationofenhanceratigf2isassociatedwithabnormaldopaminesynthesisinmajorpsychosis
_version_	1718381982395662336

Differential methylation of enhancer at IGF2 is associated with abnormal dopamine synthesis in major psychosis

Ejemplares similares