Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations.

The desert is an excellent model for studying evolution under extreme environments. We present here the complete genome and ultraviolet (UV) radiation-induced transcriptome of Deinococcus gobiensis I-0, which was isolated from the cold Gobi desert and shows higher tolerance to gamma radiation and UV...

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Autores principales:	Menglong Yuan, Ming Chen, Wei Zhang, Wei Lu, Jin Wang, Mingkun Yang, Peng Zhao, Ran Tang, Xinna Li, Yanhua Hao, Zhengfu Zhou, Yuhua Zhan, Haiying Yu, Chao Teng, Yongliang Yan, Shuzhen Ping, Yingdian Wang, Min Lin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/92422be5ad114e7787cf49faa5aff19b
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spelling	oai:doaj.org-article:92422be5ad114e7787cf49faa5aff19b2021-11-18T07:23:57ZGenome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations.1932-620310.1371/journal.pone.0034458https://doaj.org/article/92422be5ad114e7787cf49faa5aff19b2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22470573/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The desert is an excellent model for studying evolution under extreme environments. We present here the complete genome and ultraviolet (UV) radiation-induced transcriptome of Deinococcus gobiensis I-0, which was isolated from the cold Gobi desert and shows higher tolerance to gamma radiation and UV light than all other known microorganisms. Nearly half of the genes in the genome encode proteins of unknown function, suggesting that the extreme resistance phenotype may be attributed to unknown genes and pathways. D. gobiensis also contains a surprisingly large number of horizontally acquired genes and predicted mobile elements of different classes, which is indicative of adaptation to extreme environments through genomic plasticity. High-resolution RNA-Seq transcriptome analyses indicated that 30 regulatory proteins, including several well-known regulators and uncharacterized protein kinases, and 13 noncoding RNAs were induced immediately after UV irradiation. Particularly interesting is the UV irradiation induction of the phrB and recB genes involved in photoreactivation and recombinational repair, respectively. These proteins likely include key players in the immediate global transcriptional response to UV irradiation. Our results help to explain the exceptional ability of D. gobiensis to withstand environmental extremes of the Gobi desert, and highlight the metabolic features of this organism that have biotechnological potential.Menglong YuanMing ChenWei ZhangWei LuJin WangMingkun YangPeng ZhaoRan TangXinna LiYanhua HaoZhengfu ZhouYuhua ZhanHaiying YuChao TengYongliang YanShuzhen PingYingdian WangMin LinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e34458 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Menglong Yuan Ming Chen Wei Zhang Wei Lu Jin Wang Mingkun Yang Peng Zhao Ran Tang Xinna Li Yanhua Hao Zhengfu Zhou Yuhua Zhan Haiying Yu Chao Teng Yongliang Yan Shuzhen Ping Yingdian Wang Min Lin Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations.
description	The desert is an excellent model for studying evolution under extreme environments. We present here the complete genome and ultraviolet (UV) radiation-induced transcriptome of Deinococcus gobiensis I-0, which was isolated from the cold Gobi desert and shows higher tolerance to gamma radiation and UV light than all other known microorganisms. Nearly half of the genes in the genome encode proteins of unknown function, suggesting that the extreme resistance phenotype may be attributed to unknown genes and pathways. D. gobiensis also contains a surprisingly large number of horizontally acquired genes and predicted mobile elements of different classes, which is indicative of adaptation to extreme environments through genomic plasticity. High-resolution RNA-Seq transcriptome analyses indicated that 30 regulatory proteins, including several well-known regulators and uncharacterized protein kinases, and 13 noncoding RNAs were induced immediately after UV irradiation. Particularly interesting is the UV irradiation induction of the phrB and recB genes involved in photoreactivation and recombinational repair, respectively. These proteins likely include key players in the immediate global transcriptional response to UV irradiation. Our results help to explain the exceptional ability of D. gobiensis to withstand environmental extremes of the Gobi desert, and highlight the metabolic features of this organism that have biotechnological potential.
format	article
author	Menglong Yuan Ming Chen Wei Zhang Wei Lu Jin Wang Mingkun Yang Peng Zhao Ran Tang Xinna Li Yanhua Hao Zhengfu Zhou Yuhua Zhan Haiying Yu Chao Teng Yongliang Yan Shuzhen Ping Yingdian Wang Min Lin
author_facet	Menglong Yuan Ming Chen Wei Zhang Wei Lu Jin Wang Mingkun Yang Peng Zhao Ran Tang Xinna Li Yanhua Hao Zhengfu Zhou Yuhua Zhan Haiying Yu Chao Teng Yongliang Yan Shuzhen Ping Yingdian Wang Min Lin
author_sort	Menglong Yuan
title	Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations.
title_short	Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations.
title_full	Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations.
title_fullStr	Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations.
title_full_unstemmed	Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations.
title_sort	genome sequence and transcriptome analysis of the radioresistant bacterium deinococcus gobiensis: insights into the extreme environmental adaptations.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/92422be5ad114e7787cf49faa5aff19b
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Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations.

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