The <italic toggle="yes">Aspergillus fumigatus</italic> CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect

The <italic toggle="yes">Aspergillus fumigatus</italic> CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect

ABSTRACT Aspergillus fumigatus is an opportunistic fungal pathogen that causes invasive aspergillosis (IA), a life-threatening disease in immunocompromised humans. The echinocandin caspofungin, adopted as a second-line therapy in combating IA, is a β-1,3-glucan synthase inhibitor, which, when used i...

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Autores principales: Laure Nicolas Annick Ries, Marina Campos Rocha, Patrícia Alves de Castro, Rafael Silva-Rocha, Roberto Nascimento Silva, Fernanda Zanolli Freitas, Leandro José de Assis, Maria Célia Bertolini, Iran Malavazi, Gustavo H. Goldman
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Aspergillus fumigatus
cell wall integrity pathway
caspofungin
paradoxical effect
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/924300e689a4448bbaa7ea269d50f121
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