Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome

Background and purpose: Imbalance in blood levels of trace elements is independent risk factor for metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and its complications. This study investigated plasma and erythrocyte levels of copper, magnesium, zinc, and their correlations with biochemi...

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Autores principales:	Amin Omidian, Morteza Pourfarzam, Seyed Mostafa Ghanadian, Fouzieh Zadhoush
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2022
Materias:	atomic absorption spectrometry; copper; diabetes mellitus; magnesium; metabolic syndrome; zinc. Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/924326e756e344708bdd0195b77021a9
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spelling	oai:doaj.org-article:924326e756e344708bdd0195b77021a92021-11-19T12:17:03ZDetermination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome1735-53621735-941410.4103/1735-5362.329929https://doaj.org/article/924326e756e344708bdd0195b77021a92022-01-01T00:00:00Zhttp://www.rpsjournal.net/article.asp?issn=1735-5362;year=2022;volume=17;issue=1;spage=86;epage=98;aulast=Omidianhttps://doaj.org/toc/1735-5362https://doaj.org/toc/1735-9414Background and purpose: Imbalance in blood levels of trace elements is independent risk factor for metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and its complications. This study investigated plasma and erythrocyte levels of copper, magnesium, zinc, and their correlations with biochemical components of the MetS in T2DM patients compared to the healthy controls. Experimental approach: Forty men recently diagnosed T2DM with MetS without complications and thirty six age-matched healthy controls were enrolled in this cross-sectional study. Plasma and erythrocyte levels of selected elements were measured by graphite furnace atomic absorption spectroscopy. Findings/Results: The results of the present study showed significantly lower plasma levels of copper, magnesium, and zinc and lower erythrocytes copper in the patients’ group compared to the controls; while erythrocyte levels of magnesium and zinc were not significantly different between the two groups. Significant negative correlations were observed between plasma levels of copper with waist and hip circumferences, waist to hip ratio, systolic and diastolic blood pressures, fasting blood glucose, and glycated hemoglobin levels in all subjects; while erythrocyte copper levels showed significant negative correlation with triglyceride, and erythrocyte zinc was positively correlated with diastolic blood pressure and negatively with triglyceride. Conclusion and implications: Alterations of trace elements may have a significant role in the pathogenesis of MetS and T2DM patients. It is suggested that the body status of copper, magnesium, and zinc might be significantly correlated with components of MetS in T2DM patients; and plasma copper levels may be correlated with complications of type 2 diabetes mellitus.Amin OmidianMorteza PourfarzamSeyed Mostafa GhanadianFouzieh ZadhoushWolters Kluwer Medknow Publicationsarticleatomic absorption spectrometry; copper; diabetes mellitus; magnesium; metabolic syndrome; zinc.Pharmacy and materia medicaRS1-441ENResearch in Pharmaceutical Sciences, Vol 17, Iss 1, Pp 86-98 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	atomic absorption spectrometry; copper; diabetes mellitus; magnesium; metabolic syndrome; zinc. Pharmacy and materia medica RS1-441
spellingShingle	atomic absorption spectrometry; copper; diabetes mellitus; magnesium; metabolic syndrome; zinc. Pharmacy and materia medica RS1-441 Amin Omidian Morteza Pourfarzam Seyed Mostafa Ghanadian Fouzieh Zadhoush Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome
description	Background and purpose: Imbalance in blood levels of trace elements is independent risk factor for metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and its complications. This study investigated plasma and erythrocyte levels of copper, magnesium, zinc, and their correlations with biochemical components of the MetS in T2DM patients compared to the healthy controls. Experimental approach: Forty men recently diagnosed T2DM with MetS without complications and thirty six age-matched healthy controls were enrolled in this cross-sectional study. Plasma and erythrocyte levels of selected elements were measured by graphite furnace atomic absorption spectroscopy. Findings/Results: The results of the present study showed significantly lower plasma levels of copper, magnesium, and zinc and lower erythrocytes copper in the patients’ group compared to the controls; while erythrocyte levels of magnesium and zinc were not significantly different between the two groups. Significant negative correlations were observed between plasma levels of copper with waist and hip circumferences, waist to hip ratio, systolic and diastolic blood pressures, fasting blood glucose, and glycated hemoglobin levels in all subjects; while erythrocyte copper levels showed significant negative correlation with triglyceride, and erythrocyte zinc was positively correlated with diastolic blood pressure and negatively with triglyceride. Conclusion and implications: Alterations of trace elements may have a significant role in the pathogenesis of MetS and T2DM patients. It is suggested that the body status of copper, magnesium, and zinc might be significantly correlated with components of MetS in T2DM patients; and plasma copper levels may be correlated with complications of type 2 diabetes mellitus.
format	article
author	Amin Omidian Morteza Pourfarzam Seyed Mostafa Ghanadian Fouzieh Zadhoush
author_facet	Amin Omidian Morteza Pourfarzam Seyed Mostafa Ghanadian Fouzieh Zadhoush
author_sort	Amin Omidian
title	Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome
title_short	Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome
title_full	Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome
title_fullStr	Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome
title_full_unstemmed	Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome
title_sort	determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome
publisher	Wolters Kluwer Medknow Publications
publishDate	2022
url	https://doaj.org/article/924326e756e344708bdd0195b77021a9
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Determination of plasma and erythrocyte levels of copper, magnesium and zinc by atomic absorption spectrometry in type-2 diabetes mellitus patients with metabolic syndrome

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