Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Osteoarthritis: moving from symptom relief towards disease control Researchers are exploring several promising avenues to develop treatments for osteoarthritis that control or reverse its progress, rather than simply relieving the symptoms of inflammation and pain. These new opportunities are emergi...

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Autores principales:	Yongsik Cho, Sumin Jeong, Hyeonkyeong Kim, Donghyun Kang, Jeeyeon Lee, Seung-Baik Kang, Jin-Hong Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Medicine R Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/924615cd5e7447d9b16e980d2297e69a
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spelling	oai:doaj.org-article:924615cd5e7447d9b16e980d2297e69a2021-12-05T12:24:28ZDisease-modifying therapeutic strategies in osteoarthritis: current status and future directions10.1038/s12276-021-00710-y1226-36132092-6413https://doaj.org/article/924615cd5e7447d9b16e980d2297e69a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s12276-021-00710-yhttps://doaj.org/toc/1226-3613https://doaj.org/toc/2092-6413Osteoarthritis: moving from symptom relief towards disease control Researchers are exploring several promising avenues to develop treatments for osteoarthritis that control or reverse its progress, rather than simply relieving the symptoms of inflammation and pain. These new opportunities are emerging from increased understanding of the molec_reular mechanisms underlying the onset and progression of osteoarthritis. Seung-Baik Kang, Jin-Hong Kim and colleagues at Seoul National University, South Korea, review the current status and future directions of disease-modifying strategies that are already showing promise in clinical trials. They discuss approaches aimed at restricting the damage to joint cartilage by controlling the inflammatory signaling molecules, enzyme actions and molecular pathways that cause cartilage to degenerate. They also consider treatments that could stimulate the active regeneration of damaged cartilage. They conclude that some approaches will soon be ready to move into general clinical use.Yongsik ChoSumin JeongHyeonkyeong KimDonghyun KangJeeyeon LeeSeung-Baik KangJin-Hong KimNature Publishing GrouparticleMedicineRBiochemistryQD415-436ENExperimental and Molecular Medicine, Vol 53, Iss 11, Pp 1689-1696 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Biochemistry QD415-436
spellingShingle	Medicine R Biochemistry QD415-436 Yongsik Cho Sumin Jeong Hyeonkyeong Kim Donghyun Kang Jeeyeon Lee Seung-Baik Kang Jin-Hong Kim Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
description	Osteoarthritis: moving from symptom relief towards disease control Researchers are exploring several promising avenues to develop treatments for osteoarthritis that control or reverse its progress, rather than simply relieving the symptoms of inflammation and pain. These new opportunities are emerging from increased understanding of the molec_reular mechanisms underlying the onset and progression of osteoarthritis. Seung-Baik Kang, Jin-Hong Kim and colleagues at Seoul National University, South Korea, review the current status and future directions of disease-modifying strategies that are already showing promise in clinical trials. They discuss approaches aimed at restricting the damage to joint cartilage by controlling the inflammatory signaling molecules, enzyme actions and molecular pathways that cause cartilage to degenerate. They also consider treatments that could stimulate the active regeneration of damaged cartilage. They conclude that some approaches will soon be ready to move into general clinical use.
format	article
author	Yongsik Cho Sumin Jeong Hyeonkyeong Kim Donghyun Kang Jeeyeon Lee Seung-Baik Kang Jin-Hong Kim
author_facet	Yongsik Cho Sumin Jeong Hyeonkyeong Kim Donghyun Kang Jeeyeon Lee Seung-Baik Kang Jin-Hong Kim
author_sort	Yongsik Cho
title	Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
title_short	Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
title_full	Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
title_fullStr	Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
title_full_unstemmed	Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
title_sort	disease-modifying therapeutic strategies in osteoarthritis: current status and future directions
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/924615cd5e7447d9b16e980d2297e69a
work_keys_str_mv	AT yongsikcho diseasemodifyingtherapeuticstrategiesinosteoarthritiscurrentstatusandfuturedirections AT suminjeong diseasemodifyingtherapeuticstrategiesinosteoarthritiscurrentstatusandfuturedirections AT hyeonkyeongkim diseasemodifyingtherapeuticstrategiesinosteoarthritiscurrentstatusandfuturedirections AT donghyunkang diseasemodifyingtherapeuticstrategiesinosteoarthritiscurrentstatusandfuturedirections AT jeeyeonlee diseasemodifyingtherapeuticstrategiesinosteoarthritiscurrentstatusandfuturedirections AT seungbaikkang diseasemodifyingtherapeuticstrategiesinosteoarthritiscurrentstatusandfuturedirections AT jinhongkim diseasemodifyingtherapeuticstrategiesinosteoarthritiscurrentstatusandfuturedirections
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Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

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