Neuroprotective role of retinal SIRT3 against acute photo-stress

Author Summary Sirtuins are nicotinamide adenine dinucleotide-dependent protein deacetylases. Among seven sirtuins, SIRT3 is a key regulator of mitochondrial function. However, functions of SIRT3 in the retina are largely unknown. In this study, we investigated the role of retinal SIRT3 in a mouse m...

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Autores principales:	Norimitsu Ban, Yoko Ozawa, Hideto Osada, Jonathan B. Lin, Eriko Toda, Mitsuhiro Watanabe, Kenya Yuki, Shunsuke Kubota, Rajendra S. Apte, Kazuo Tsubota
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/92495cab1dba4cccbc679a25927d2256
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spelling	oai:doaj.org-article:92495cab1dba4cccbc679a25927d22562021-12-02T14:22:13ZNeuroprotective role of retinal SIRT3 against acute photo-stress10.1038/s41514-017-0017-82056-3973https://doaj.org/article/92495cab1dba4cccbc679a25927d22562017-12-01T00:00:00Zhttps://doi.org/10.1038/s41514-017-0017-8https://doaj.org/toc/2056-3973Author Summary Sirtuins are nicotinamide adenine dinucleotide-dependent protein deacetylases. Among seven sirtuins, SIRT3 is a key regulator of mitochondrial function. However, functions of SIRT3 in the retina are largely unknown. In this study, we investigated the role of retinal SIRT3 in a mouse model of light-induced retinal degeneration, found that SIRT3 has neuroprotective role in the retina. We demonstrate that SIRT3 deficiency causes acute reactive oxygen species accumulation and endoplasmic reticulum stress in the retina after the light exposure, which leads to increased photoreceptor death, retinal thinning, and decreased retinal function. Using a photoreceptor-derived cell line, we revealed that reactive oxygen species were the upstream initiators of endoplasmic reticulum stress, and decreased superoxide dismutase 2 activity led to elevated intracellular reactive oxygen species. These results suggest that SIRT3 might be a therapeutic target for oxidative stress-induced retinal disorders.Norimitsu BanYoko OzawaHideto OsadaJonathan B. LinEriko TodaMitsuhiro WatanabeKenya YukiShunsuke KubotaRajendra S. ApteKazuo TsubotaNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Norimitsu Ban Yoko Ozawa Hideto Osada Jonathan B. Lin Eriko Toda Mitsuhiro Watanabe Kenya Yuki Shunsuke Kubota Rajendra S. Apte Kazuo Tsubota Neuroprotective role of retinal SIRT3 against acute photo-stress
description	Author Summary Sirtuins are nicotinamide adenine dinucleotide-dependent protein deacetylases. Among seven sirtuins, SIRT3 is a key regulator of mitochondrial function. However, functions of SIRT3 in the retina are largely unknown. In this study, we investigated the role of retinal SIRT3 in a mouse model of light-induced retinal degeneration, found that SIRT3 has neuroprotective role in the retina. We demonstrate that SIRT3 deficiency causes acute reactive oxygen species accumulation and endoplasmic reticulum stress in the retina after the light exposure, which leads to increased photoreceptor death, retinal thinning, and decreased retinal function. Using a photoreceptor-derived cell line, we revealed that reactive oxygen species were the upstream initiators of endoplasmic reticulum stress, and decreased superoxide dismutase 2 activity led to elevated intracellular reactive oxygen species. These results suggest that SIRT3 might be a therapeutic target for oxidative stress-induced retinal disorders.
format	article
author	Norimitsu Ban Yoko Ozawa Hideto Osada Jonathan B. Lin Eriko Toda Mitsuhiro Watanabe Kenya Yuki Shunsuke Kubota Rajendra S. Apte Kazuo Tsubota
author_facet	Norimitsu Ban Yoko Ozawa Hideto Osada Jonathan B. Lin Eriko Toda Mitsuhiro Watanabe Kenya Yuki Shunsuke Kubota Rajendra S. Apte Kazuo Tsubota
author_sort	Norimitsu Ban
title	Neuroprotective role of retinal SIRT3 against acute photo-stress
title_short	Neuroprotective role of retinal SIRT3 against acute photo-stress
title_full	Neuroprotective role of retinal SIRT3 against acute photo-stress
title_fullStr	Neuroprotective role of retinal SIRT3 against acute photo-stress
title_full_unstemmed	Neuroprotective role of retinal SIRT3 against acute photo-stress
title_sort	neuroprotective role of retinal sirt3 against acute photo-stress
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/92495cab1dba4cccbc679a25927d2256
work_keys_str_mv	AT norimitsuban neuroprotectiveroleofretinalsirt3againstacutephotostress AT yokoozawa neuroprotectiveroleofretinalsirt3againstacutephotostress AT hidetoosada neuroprotectiveroleofretinalsirt3againstacutephotostress AT jonathanblin neuroprotectiveroleofretinalsirt3againstacutephotostress AT erikotoda neuroprotectiveroleofretinalsirt3againstacutephotostress AT mitsuhirowatanabe neuroprotectiveroleofretinalsirt3againstacutephotostress AT kenyayuki neuroprotectiveroleofretinalsirt3againstacutephotostress AT shunsukekubota neuroprotectiveroleofretinalsirt3againstacutephotostress AT rajendrasapte neuroprotectiveroleofretinalsirt3againstacutephotostress AT kazuotsubota neuroprotectiveroleofretinalsirt3againstacutephotostress
_version_	1718391501678968832

Neuroprotective role of retinal SIRT3 against acute photo-stress

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