β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer

YAP and mutant p53 crosstalk to regulate transcriptional processes in cancers. Here, the authors show that endothelin-1 mediated activation of β-arrestin interacts with YAP to recruit mutant p53 to the TEAD/YAP complex to promote metastasis and chemoresistance in ovarian cancer.

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Detalles Bibliográficos
Autores principales:	Piera Tocci, Roberta Cianfrocca, Valeriana Di Castro, Laura Rosanò, Andrea Sacconi, Sara Donzelli, Silvia Bonfiglio, Gabriele Bucci, Enrico Vizza, Gabriella Ferrandina, Giovanni Scambia, Giovanni Tonon, Giovanni Blandino, Anna Bagnato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/924a8b602fdb4153a08a0593bfc1aea7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:924a8b602fdb4153a08a0593bfc1aea72021-12-02T15:35:37Zβ-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer10.1038/s41467-019-11045-82041-1723https://doaj.org/article/924a8b602fdb4153a08a0593bfc1aea72019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11045-8https://doaj.org/toc/2041-1723YAP and mutant p53 crosstalk to regulate transcriptional processes in cancers. Here, the authors show that endothelin-1 mediated activation of β-arrestin interacts with YAP to recruit mutant p53 to the TEAD/YAP complex to promote metastasis and chemoresistance in ovarian cancer.Piera TocciRoberta CianfroccaValeriana Di CastroLaura RosanòAndrea SacconiSara DonzelliSilvia BonfiglioGabriele BucciEnrico VizzaGabriella FerrandinaGiovanni ScambiaGiovanni TononGiovanni BlandinoAnna BagnatoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Piera Tocci Roberta Cianfrocca Valeriana Di Castro Laura Rosanò Andrea Sacconi Sara Donzelli Silvia Bonfiglio Gabriele Bucci Enrico Vizza Gabriella Ferrandina Giovanni Scambia Giovanni Tonon Giovanni Blandino Anna Bagnato β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer
description	YAP and mutant p53 crosstalk to regulate transcriptional processes in cancers. Here, the authors show that endothelin-1 mediated activation of β-arrestin interacts with YAP to recruit mutant p53 to the TEAD/YAP complex to promote metastasis and chemoresistance in ovarian cancer.
format	article
author	Piera Tocci Roberta Cianfrocca Valeriana Di Castro Laura Rosanò Andrea Sacconi Sara Donzelli Silvia Bonfiglio Gabriele Bucci Enrico Vizza Gabriella Ferrandina Giovanni Scambia Giovanni Tonon Giovanni Blandino Anna Bagnato
author_facet	Piera Tocci Roberta Cianfrocca Valeriana Di Castro Laura Rosanò Andrea Sacconi Sara Donzelli Silvia Bonfiglio Gabriele Bucci Enrico Vizza Gabriella Ferrandina Giovanni Scambia Giovanni Tonon Giovanni Blandino Anna Bagnato
author_sort	Piera Tocci
title	β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer
title_short	β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer
title_full	β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer
title_fullStr	β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer
title_full_unstemmed	β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer
title_sort	β-arrestin1/yap/mutant p53 complexes orchestrate the endothelin a receptor signaling in high-grade serous ovarian cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/924a8b602fdb4153a08a0593bfc1aea7
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β-arrestin1/YAP/mutant p53 complexes orchestrate the endothelin A receptor signaling in high-grade serous ovarian cancer

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