The Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review
BackgroundExogenous sex steroids within hormonal contraception and menopausal hormone therapy (MHT) have been used for family planning and management of menopausal symptoms, without consideration of their effects on the vaginal microbiota. This is largely because their use predates our understanding...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:924a8e08ae6942c4aae617b98e5d44a12021-11-12T05:41:29ZThe Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review2235-298810.3389/fcimb.2021.732423https://doaj.org/article/924a8e08ae6942c4aae617b98e5d44a12021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcimb.2021.732423/fullhttps://doaj.org/toc/2235-2988BackgroundExogenous sex steroids within hormonal contraception and menopausal hormone therapy (MHT) have been used for family planning and management of menopausal symptoms, without consideration of their effects on the vaginal microbiota. This is largely because their use predates our understanding of the importance of the vaginal microbiome on human health. We conducted a systematic review (PROSPERO: CRD42018107730) to determine the influence of exogenous sex steroids, stratified by oestrogen-containing or progestin-only types of contraception, and MHT on the vaginal microbiome, as measured by molecular methods.MethodsEmbase, PubMed and Medline were searched for relevant literature published through to December 1st 2020. Eligible studies reported on the effect of specific exogenous sex steroids on the vaginal microbiome using a molecular method. Data regarding the ‘positive’, ‘negative’ or ‘neutral’ effect of each type of contraceptive or MHT on the vaginal microbiome was extracted and summarised. A positive effect reflected sex steroid exposure that was associated with increased abundance of lactobacilli, a change to, or maintenance of, an optimal vaginal microbiota composition, or a decrease in bacterial diversity (specifically reflecting a low-diversity optimal microbiota state), relative to the control group. An exogenous sex steroid was designated as having a negative effect on the vaginal microbiome if it resulted in opposing effects (i.e. loss of lactobacilli, a non-optimal microbiota state). When no significant change was found, this was considered neutral/inconclusive.ResultsWe identified 29 manuscripts reporting on the effect of exogenous sex steroids on the vaginal microbiome; 25 investigating hormonal contraceptives, and 4 investigating MHT. Oestrogen-containing contraception, particularly reflecting the combined oestrogen and progestin-containing contraceptive pill, had a positive effect on the composition of the vaginal microbiota. Progestin-only contraception, particularly reflecting depo-medroxyprogesterone acetate, had mixed effects on the microbiota. Among post-menopausal women using MHT, exogenous oestrogen applied topically was associated with increased prevalence of lactobacilli.ConclusionOur findings suggest that oestrogen-containing compounds may promote an optimal vaginal microbiota, which could have clinical applications. The impact of progestin-only contraceptives on the vaginal microbiota is less clear; more data is needed to determine how progestin-only contraceptives contribute to adverse reproductive and sexual health outcomes.Larissa K. RattenLarissa K. RattenErica L. PlummerErica L. PlummerCatriona S. BradshawCatriona S. BradshawCatriona S. BradshawChristopher K. FairleyChristopher K. FairleyGerald L. MurrayGerald L. MurrayGerald L. MurraySuzanne M. GarlandSuzanne M. GarlandSuzanne M. GarlandDeborah BatesonDeborah BatesonGilda TachedjianGilda TachedjianGilda TachedjianLindi MassonLindi MassonLindi MassonLindi MassonLenka A. VodstrcilLenka A. VodstrcilLenka A. VodstrcilFrontiers Media S.A.articlevaginal microbiotahormonal contraceptivesmenopausal hormone therapylactobacillusGardnerella vaginalisoestrogenMicrobiologyQR1-502ENFrontiers in Cellular and Infection Microbiology, Vol 11 (2021) |
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vaginal microbiota hormonal contraceptives menopausal hormone therapy lactobacillus Gardnerella vaginalis oestrogen Microbiology QR1-502 |
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vaginal microbiota hormonal contraceptives menopausal hormone therapy lactobacillus Gardnerella vaginalis oestrogen Microbiology QR1-502 Larissa K. Ratten Larissa K. Ratten Erica L. Plummer Erica L. Plummer Catriona S. Bradshaw Catriona S. Bradshaw Catriona S. Bradshaw Christopher K. Fairley Christopher K. Fairley Gerald L. Murray Gerald L. Murray Gerald L. Murray Suzanne M. Garland Suzanne M. Garland Suzanne M. Garland Deborah Bateson Deborah Bateson Gilda Tachedjian Gilda Tachedjian Gilda Tachedjian Lindi Masson Lindi Masson Lindi Masson Lindi Masson Lenka A. Vodstrcil Lenka A. Vodstrcil Lenka A. Vodstrcil The Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review |
| description |
BackgroundExogenous sex steroids within hormonal contraception and menopausal hormone therapy (MHT) have been used for family planning and management of menopausal symptoms, without consideration of their effects on the vaginal microbiota. This is largely because their use predates our understanding of the importance of the vaginal microbiome on human health. We conducted a systematic review (PROSPERO: CRD42018107730) to determine the influence of exogenous sex steroids, stratified by oestrogen-containing or progestin-only types of contraception, and MHT on the vaginal microbiome, as measured by molecular methods.MethodsEmbase, PubMed and Medline were searched for relevant literature published through to December 1st 2020. Eligible studies reported on the effect of specific exogenous sex steroids on the vaginal microbiome using a molecular method. Data regarding the ‘positive’, ‘negative’ or ‘neutral’ effect of each type of contraceptive or MHT on the vaginal microbiome was extracted and summarised. A positive effect reflected sex steroid exposure that was associated with increased abundance of lactobacilli, a change to, or maintenance of, an optimal vaginal microbiota composition, or a decrease in bacterial diversity (specifically reflecting a low-diversity optimal microbiota state), relative to the control group. An exogenous sex steroid was designated as having a negative effect on the vaginal microbiome if it resulted in opposing effects (i.e. loss of lactobacilli, a non-optimal microbiota state). When no significant change was found, this was considered neutral/inconclusive.ResultsWe identified 29 manuscripts reporting on the effect of exogenous sex steroids on the vaginal microbiome; 25 investigating hormonal contraceptives, and 4 investigating MHT. Oestrogen-containing contraception, particularly reflecting the combined oestrogen and progestin-containing contraceptive pill, had a positive effect on the composition of the vaginal microbiota. Progestin-only contraception, particularly reflecting depo-medroxyprogesterone acetate, had mixed effects on the microbiota. Among post-menopausal women using MHT, exogenous oestrogen applied topically was associated with increased prevalence of lactobacilli.ConclusionOur findings suggest that oestrogen-containing compounds may promote an optimal vaginal microbiota, which could have clinical applications. The impact of progestin-only contraceptives on the vaginal microbiota is less clear; more data is needed to determine how progestin-only contraceptives contribute to adverse reproductive and sexual health outcomes. |
| format |
article |
| author |
Larissa K. Ratten Larissa K. Ratten Erica L. Plummer Erica L. Plummer Catriona S. Bradshaw Catriona S. Bradshaw Catriona S. Bradshaw Christopher K. Fairley Christopher K. Fairley Gerald L. Murray Gerald L. Murray Gerald L. Murray Suzanne M. Garland Suzanne M. Garland Suzanne M. Garland Deborah Bateson Deborah Bateson Gilda Tachedjian Gilda Tachedjian Gilda Tachedjian Lindi Masson Lindi Masson Lindi Masson Lindi Masson Lenka A. Vodstrcil Lenka A. Vodstrcil Lenka A. Vodstrcil |
| author_facet |
Larissa K. Ratten Larissa K. Ratten Erica L. Plummer Erica L. Plummer Catriona S. Bradshaw Catriona S. Bradshaw Catriona S. Bradshaw Christopher K. Fairley Christopher K. Fairley Gerald L. Murray Gerald L. Murray Gerald L. Murray Suzanne M. Garland Suzanne M. Garland Suzanne M. Garland Deborah Bateson Deborah Bateson Gilda Tachedjian Gilda Tachedjian Gilda Tachedjian Lindi Masson Lindi Masson Lindi Masson Lindi Masson Lenka A. Vodstrcil Lenka A. Vodstrcil Lenka A. Vodstrcil |
| author_sort |
Larissa K. Ratten |
| title |
The Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review |
| title_short |
The Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review |
| title_full |
The Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review |
| title_fullStr |
The Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review |
| title_full_unstemmed |
The Effect of Exogenous Sex Steroids on the Vaginal Microbiota: A Systematic Review |
| title_sort |
effect of exogenous sex steroids on the vaginal microbiota: a systematic review |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/924a8e08ae6942c4aae617b98e5d44a1 |
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