Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty

Keratoplasty is the gold standard treatment for visual impairment caused by corneal damage. The use of suturing as the bonding method is the source of many complications following keratoplasty. Currently available corneal adhesives do not have both adequate adhesive strength and acceptable biocompat...

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Autores principales:	Xuan Zhao, Saiqun Li, Xinyue Du, Weihua Li, Qian Wang, Dalian He, Jin Yuan
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Bioadhesive hydrogels Photocurable Cornea repair Sutureless keratoplasty Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/924cb453800e4c3f9fbfc640eb41b60d
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spelling	oai:doaj.org-article:924cb453800e4c3f9fbfc640eb41b60d2021-11-04T04:36:26ZNatural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty2452-199X10.1016/j.bioactmat.2021.07.001https://doaj.org/article/924cb453800e4c3f9fbfc640eb41b60d2022-02-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21003224https://doaj.org/toc/2452-199XKeratoplasty is the gold standard treatment for visual impairment caused by corneal damage. The use of suturing as the bonding method is the source of many complications following keratoplasty. Currently available corneal adhesives do not have both adequate adhesive strength and acceptable biocompatibility. Herein, we developed a photocurable bioadhesive hydrogel which was composed of gelatin methacryloyl and oxidized dextran for sutureless keratoplasty. The bioadhesive hydrogel exhibited high light transmittance, resistance to enzymatic degradation and excellent biocompatibility. It also had higher adhesive strength than commercial adhesives (fibrin glue). In a rabbit model of lamellar keratoplasty, donor corneal grafts could be closely bonded to the recipient corneal bed and remained attached for 56 days by using of this in situ photopolymerized bioadhesive hydrogel. The operated cornea maintained transparent and noninflamed. Sutureless keratoplasty using bioadhesive hydrogel allowed rapid graft re-epithelialization, typically within 7 days. In vivo confocal microscopic and histological evaluation of the operated cornea did not show any apparent abnormalities in terms of corneal cells and ultrastructure. Thus, this bioadhesive hydrogel is exhibited to be an appealing alternative to sutures for keratoplasty and other corneal surgeries.Xuan ZhaoSaiqun LiXinyue DuWeihua LiQian WangDalian HeJin YuanKeAi Communications Co., Ltd.articleBioadhesive hydrogelsPhotocurableCornea repairSutureless keratoplastyMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 8, Iss , Pp 196-209 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bioadhesive hydrogels Photocurable Cornea repair Sutureless keratoplasty Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Bioadhesive hydrogels Photocurable Cornea repair Sutureless keratoplasty Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Xuan Zhao Saiqun Li Xinyue Du Weihua Li Qian Wang Dalian He Jin Yuan Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty
description	Keratoplasty is the gold standard treatment for visual impairment caused by corneal damage. The use of suturing as the bonding method is the source of many complications following keratoplasty. Currently available corneal adhesives do not have both adequate adhesive strength and acceptable biocompatibility. Herein, we developed a photocurable bioadhesive hydrogel which was composed of gelatin methacryloyl and oxidized dextran for sutureless keratoplasty. The bioadhesive hydrogel exhibited high light transmittance, resistance to enzymatic degradation and excellent biocompatibility. It also had higher adhesive strength than commercial adhesives (fibrin glue). In a rabbit model of lamellar keratoplasty, donor corneal grafts could be closely bonded to the recipient corneal bed and remained attached for 56 days by using of this in situ photopolymerized bioadhesive hydrogel. The operated cornea maintained transparent and noninflamed. Sutureless keratoplasty using bioadhesive hydrogel allowed rapid graft re-epithelialization, typically within 7 days. In vivo confocal microscopic and histological evaluation of the operated cornea did not show any apparent abnormalities in terms of corneal cells and ultrastructure. Thus, this bioadhesive hydrogel is exhibited to be an appealing alternative to sutures for keratoplasty and other corneal surgeries.
format	article
author	Xuan Zhao Saiqun Li Xinyue Du Weihua Li Qian Wang Dalian He Jin Yuan
author_facet	Xuan Zhao Saiqun Li Xinyue Du Weihua Li Qian Wang Dalian He Jin Yuan
author_sort	Xuan Zhao
title	Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty
title_short	Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty
title_full	Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty
title_fullStr	Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty
title_full_unstemmed	Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty
title_sort	natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/924cb453800e4c3f9fbfc640eb41b60d
work_keys_str_mv	AT xuanzhao naturalpolymerderivedphotocurablebioadhesivehydrogelsforsuturelesskeratoplasty AT saiqunli naturalpolymerderivedphotocurablebioadhesivehydrogelsforsuturelesskeratoplasty AT xinyuedu naturalpolymerderivedphotocurablebioadhesivehydrogelsforsuturelesskeratoplasty AT weihuali naturalpolymerderivedphotocurablebioadhesivehydrogelsforsuturelesskeratoplasty AT qianwang naturalpolymerderivedphotocurablebioadhesivehydrogelsforsuturelesskeratoplasty AT dalianhe naturalpolymerderivedphotocurablebioadhesivehydrogelsforsuturelesskeratoplasty AT jinyuan naturalpolymerderivedphotocurablebioadhesivehydrogelsforsuturelesskeratoplasty
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Natural polymer-derived photocurable bioadhesive hydrogels for sutureless keratoplasty

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