Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis

Abstract We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and health...

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Autores principales:	J. M. Hatcher-Martin, J. L. McKay, A. F. Pybus, B. Sommerfeld, J. C. Howell, F. C. Goldstein, L. Wood, W. T. Hu, S. A. Factor
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/924d91281f934f699f164f0dae6b1608
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spelling	oai:doaj.org-article:924d91281f934f699f164f0dae6b16082021-12-05T12:17:22ZCerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis10.1038/s41531-021-00247-x2373-8057https://doaj.org/article/924d91281f934f699f164f0dae6b16082021-11-01T00:00:00Zhttps://doi.org/10.1038/s41531-021-00247-xhttps://doaj.org/toc/2373-8057Abstract We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and healthy controls (HC, N = 12). Age and PD duration are not significantly different between groups. After adjusting for covariates and multiple comparisons, the anti-inflammatory marker, fractalkine, is significantly decreased in the PD groups compared to HC (P = 0.002), and further decreased in PD-FOG compared to PD-NoFOG (P = 0.007). The Alzheimer’s disease-related protein, Aβ42, is increased in PD-FOG compared to PD-NoFOG and HC (P = 0.001). Group differences obtained in individual biomarker analyses are confirmed with multivariate discriminant partial least squares regression (P < 0.001). High levels of Aβ42 in PD-FOG patients supports an increase over time from early to advanced state. Low levels of fractalkine might suggest anti-inflammatory effect. These findings warrant replication.J. M. Hatcher-MartinJ. L. McKayA. F. PybusB. SommerfeldJ. C. HowellF. C. GoldsteinL. WoodW. T. HuS. A. FactorNature PortfolioarticleNeurology. Diseases of the nervous systemRC346-429ENnpj Parkinson's Disease, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurology. Diseases of the nervous system RC346-429 J. M. Hatcher-Martin J. L. McKay A. F. Pybus B. Sommerfeld J. C. Howell F. C. Goldstein L. Wood W. T. Hu S. A. Factor Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis
description	Abstract We explore the association between three Alzheimer’s disease-related and ten inflammation-related CSF markers and freezing of gait (FOG) in patients with Parkinson’s disease (PD). The study population includes PD patients with FOG (PD-FOG, N = 12), without FOG (PD-NoFOG, N = 19), and healthy controls (HC, N = 12). Age and PD duration are not significantly different between groups. After adjusting for covariates and multiple comparisons, the anti-inflammatory marker, fractalkine, is significantly decreased in the PD groups compared to HC (P = 0.002), and further decreased in PD-FOG compared to PD-NoFOG (P = 0.007). The Alzheimer’s disease-related protein, Aβ42, is increased in PD-FOG compared to PD-NoFOG and HC (P = 0.001). Group differences obtained in individual biomarker analyses are confirmed with multivariate discriminant partial least squares regression (P < 0.001). High levels of Aβ42 in PD-FOG patients supports an increase over time from early to advanced state. Low levels of fractalkine might suggest anti-inflammatory effect. These findings warrant replication.
format	article
author	J. M. Hatcher-Martin J. L. McKay A. F. Pybus B. Sommerfeld J. C. Howell F. C. Goldstein L. Wood W. T. Hu S. A. Factor
author_facet	J. M. Hatcher-Martin J. L. McKay A. F. Pybus B. Sommerfeld J. C. Howell F. C. Goldstein L. Wood W. T. Hu S. A. Factor
author_sort	J. M. Hatcher-Martin
title	Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis
title_short	Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis
title_full	Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis
title_fullStr	Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis
title_full_unstemmed	Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis
title_sort	cerebrospinal fluid biomarkers in parkinson’s disease with freezing of gait: an exploratory analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/924d91281f934f699f164f0dae6b1608
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Cerebrospinal fluid biomarkers in Parkinson’s disease with freezing of gait: an exploratory analysis

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