Serum carcinoembryonic antigen elevation in benign lung diseases

Abstract Carcinoembryonic antigen (CEA) is not only used to aid the diagnosis of lung cancer, but also help monitor recurrence and determine the prognosis of lung cancer as well as evaluate the therapeutic efficacy for lung cancer. However, studies have also shown that CEA is present at low levels i...

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Autores principales:	Yi Yang, Mingfang Xu, Huan Huang, Xiaolin Jiang, Kan Gong, Yun Liu, Xunjie Kuang, Xueqin Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/924e05edb5b444b78cebd69ab1fc4b93
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spelling	oai:doaj.org-article:924e05edb5b444b78cebd69ab1fc4b932021-12-02T18:14:08ZSerum carcinoembryonic antigen elevation in benign lung diseases10.1038/s41598-021-98513-82045-2322https://doaj.org/article/924e05edb5b444b78cebd69ab1fc4b932021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98513-8https://doaj.org/toc/2045-2322Abstract Carcinoembryonic antigen (CEA) is not only used to aid the diagnosis of lung cancer, but also help monitor recurrence and determine the prognosis of lung cancer as well as evaluate the therapeutic efficacy for lung cancer. However, studies have also shown that CEA is present at low levels in the serum of patients with benign lung diseases (BLD), which will interfere with the accurate judgment of the disease. Due to difference in sample size, detection methods, cutoff values and sources of BLD, the positive rate of CEA in BLD is different with different literature. Therefore, it is necessary to define CEA levels in patients of different BLD in a large sample study. 4796 patients with BLD were included in this study. The results showed that the CEA levels of 3.1% (149/4796) patients with BLD were elevated, with three cases exceeds 20 ng/mL (0.06%, 3/4796). The results from the literature showed that BLD had a mean positive rate of 5.99% (53/885) and only two cases had CEA above 20 ng/mL. The CEA elevations mainly distributed in chronic obstructive pulmonary disease (COPD), pneumonitis and interstitial lung disease and significantly correlated with age of patients (OR 2.69, 95% CI 1.94–3.73, p < 0.001). Pulmonary tuberculosis (7/1311, 0.53%) had the lowest positive rate of CEA elevations while pulmonary alveolar proteinosis (6/27, 22.22%) had the highest positive rate. The majority of patients with abnormally elevated CEA levels had multiple underlying diseases, mainly diseases of the circulatory system (42.28% [63/149]), endocrine diseases (26.85% [40/149]), and respiratory or heart failure (24.16% [36/149]. In endocrine diseases, 87.5% (35/40) of patients had diabetes. In conclusion, CEA is present at a low positive rate in the serum of patients with BLD, but few exceed 20 ng/mL. For lung disease patients, if CEA levels rise, we should carry out comprehensive analysis of types of lung diseases, age of patients, and comorbid diseases.Yi YangMingfang XuHuan HuangXiaolin JiangKan GongYun LiuXunjie KuangXueqin YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi Yang Mingfang Xu Huan Huang Xiaolin Jiang Kan Gong Yun Liu Xunjie Kuang Xueqin Yang Serum carcinoembryonic antigen elevation in benign lung diseases
description	Abstract Carcinoembryonic antigen (CEA) is not only used to aid the diagnosis of lung cancer, but also help monitor recurrence and determine the prognosis of lung cancer as well as evaluate the therapeutic efficacy for lung cancer. However, studies have also shown that CEA is present at low levels in the serum of patients with benign lung diseases (BLD), which will interfere with the accurate judgment of the disease. Due to difference in sample size, detection methods, cutoff values and sources of BLD, the positive rate of CEA in BLD is different with different literature. Therefore, it is necessary to define CEA levels in patients of different BLD in a large sample study. 4796 patients with BLD were included in this study. The results showed that the CEA levels of 3.1% (149/4796) patients with BLD were elevated, with three cases exceeds 20 ng/mL (0.06%, 3/4796). The results from the literature showed that BLD had a mean positive rate of 5.99% (53/885) and only two cases had CEA above 20 ng/mL. The CEA elevations mainly distributed in chronic obstructive pulmonary disease (COPD), pneumonitis and interstitial lung disease and significantly correlated with age of patients (OR 2.69, 95% CI 1.94–3.73, p < 0.001). Pulmonary tuberculosis (7/1311, 0.53%) had the lowest positive rate of CEA elevations while pulmonary alveolar proteinosis (6/27, 22.22%) had the highest positive rate. The majority of patients with abnormally elevated CEA levels had multiple underlying diseases, mainly diseases of the circulatory system (42.28% [63/149]), endocrine diseases (26.85% [40/149]), and respiratory or heart failure (24.16% [36/149]. In endocrine diseases, 87.5% (35/40) of patients had diabetes. In conclusion, CEA is present at a low positive rate in the serum of patients with BLD, but few exceed 20 ng/mL. For lung disease patients, if CEA levels rise, we should carry out comprehensive analysis of types of lung diseases, age of patients, and comorbid diseases.
format	article
author	Yi Yang Mingfang Xu Huan Huang Xiaolin Jiang Kan Gong Yun Liu Xunjie Kuang Xueqin Yang
author_facet	Yi Yang Mingfang Xu Huan Huang Xiaolin Jiang Kan Gong Yun Liu Xunjie Kuang Xueqin Yang
author_sort	Yi Yang
title	Serum carcinoembryonic antigen elevation in benign lung diseases
title_short	Serum carcinoembryonic antigen elevation in benign lung diseases
title_full	Serum carcinoembryonic antigen elevation in benign lung diseases
title_fullStr	Serum carcinoembryonic antigen elevation in benign lung diseases
title_full_unstemmed	Serum carcinoembryonic antigen elevation in benign lung diseases
title_sort	serum carcinoembryonic antigen elevation in benign lung diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/924e05edb5b444b78cebd69ab1fc4b93
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Serum carcinoembryonic antigen elevation in benign lung diseases

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