H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity

ABSTRACT The ongoing H7N9 influenza epizootic in China once again presents us questions about the origin of pandemics and how to recognize them in early stages of development. Over the past ~135 years, H7 influenza viruses have neither caused pandemics nor been recognized as having undergone human a...

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Autores principales:	David M. Morens, Jeffery K. Taubenberger, Anthony S. Fauci
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/924e1b3935084b8dafe6bb2abada6022
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spelling	oai:doaj.org-article:924e1b3935084b8dafe6bb2abada60222021-11-15T15:43:10ZH7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity10.1128/mBio.00445-132150-7511https://doaj.org/article/924e1b3935084b8dafe6bb2abada60222013-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00445-13https://doaj.org/toc/2150-7511ABSTRACT The ongoing H7N9 influenza epizootic in China once again presents us questions about the origin of pandemics and how to recognize them in early stages of development. Over the past ~135 years, H7 influenza viruses have neither caused pandemics nor been recognized as having undergone human adaptation. Yet several unusual properties of these viruses, including their poultry epizootic potential, mammalian adaptation, and atypical clinical syndromes in rarely infected humans, suggest that they may be different from other avian influenza viruses, thus questioning any assurance that the likelihood of human adaptation is low. At the same time, the H7N9 epizootic provides an opportunity to learn more about the mammalian/human adaptational capabilities of avian influenza viruses and challenges us to integrate virologic and public health research and surveillance at the animal-human interface.David M. MorensJeffery K. TaubenbergerAnthony S. FauciAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 4 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 David M. Morens Jeffery K. Taubenberger Anthony S. Fauci H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity
description	ABSTRACT The ongoing H7N9 influenza epizootic in China once again presents us questions about the origin of pandemics and how to recognize them in early stages of development. Over the past ~135 years, H7 influenza viruses have neither caused pandemics nor been recognized as having undergone human adaptation. Yet several unusual properties of these viruses, including their poultry epizootic potential, mammalian adaptation, and atypical clinical syndromes in rarely infected humans, suggest that they may be different from other avian influenza viruses, thus questioning any assurance that the likelihood of human adaptation is low. At the same time, the H7N9 epizootic provides an opportunity to learn more about the mammalian/human adaptational capabilities of avian influenza viruses and challenges us to integrate virologic and public health research and surveillance at the animal-human interface.
format	article
author	David M. Morens Jeffery K. Taubenberger Anthony S. Fauci
author_facet	David M. Morens Jeffery K. Taubenberger Anthony S. Fauci
author_sort	David M. Morens
title	H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity
title_short	H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity
title_full	H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity
title_fullStr	H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity
title_full_unstemmed	H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity
title_sort	h7n9 avian influenza a virus and the perpetual challenge of potential human pandemicity
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/924e1b3935084b8dafe6bb2abada6022
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H7N9 Avian Influenza A Virus and the Perpetual Challenge of Potential Human Pandemicity

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