Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma
Recurrent metastatic rhabdomyosarcoma remains largely incurable. Here, the authors describe a child with metastatic rhabdomyosarcoma who has durable response to HER2-specific CAR T cells and shows endogenous immune reactivity.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/924e95c7aec9406f9a123abaaaf5e1e2 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:924e95c7aec9406f9a123abaaaf5e1e2 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:924e95c7aec9406f9a123abaaaf5e1e22021-12-02T18:36:59ZTumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma10.1038/s41467-020-17175-82041-1723https://doaj.org/article/924e95c7aec9406f9a123abaaaf5e1e22020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17175-8https://doaj.org/toc/2041-1723Recurrent metastatic rhabdomyosarcoma remains largely incurable. Here, the authors describe a child with metastatic rhabdomyosarcoma who has durable response to HER2-specific CAR T cells and shows endogenous immune reactivity.Meenakshi HegdeSujith K. JosephFarzana PashankarChristopher DeRenzoKhaled SanberShoba NavaiTiara T. ByrdJohn HicksMina L. XuClaudia GerkenMamta KalraCatherine RobertsonHuimin ZhangAnkita ShreeBirju MehtaOlga DakhovaVita S. SalsmanBambi GrilleyAdrian GeeGianpietro DottiHelen E. HeslopMalcolm K. BrennerWinfried S. WelsStephen GottschalkNabil AhmedNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Meenakshi Hegde Sujith K. Joseph Farzana Pashankar Christopher DeRenzo Khaled Sanber Shoba Navai Tiara T. Byrd John Hicks Mina L. Xu Claudia Gerken Mamta Kalra Catherine Robertson Huimin Zhang Ankita Shree Birju Mehta Olga Dakhova Vita S. Salsman Bambi Grilley Adrian Gee Gianpietro Dotti Helen E. Heslop Malcolm K. Brenner Winfried S. Wels Stephen Gottschalk Nabil Ahmed Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma |
| description |
Recurrent metastatic rhabdomyosarcoma remains largely incurable. Here, the authors describe a child with metastatic rhabdomyosarcoma who has durable response to HER2-specific CAR T cells and shows endogenous immune reactivity. |
| format |
article |
| author |
Meenakshi Hegde Sujith K. Joseph Farzana Pashankar Christopher DeRenzo Khaled Sanber Shoba Navai Tiara T. Byrd John Hicks Mina L. Xu Claudia Gerken Mamta Kalra Catherine Robertson Huimin Zhang Ankita Shree Birju Mehta Olga Dakhova Vita S. Salsman Bambi Grilley Adrian Gee Gianpietro Dotti Helen E. Heslop Malcolm K. Brenner Winfried S. Wels Stephen Gottschalk Nabil Ahmed |
| author_facet |
Meenakshi Hegde Sujith K. Joseph Farzana Pashankar Christopher DeRenzo Khaled Sanber Shoba Navai Tiara T. Byrd John Hicks Mina L. Xu Claudia Gerken Mamta Kalra Catherine Robertson Huimin Zhang Ankita Shree Birju Mehta Olga Dakhova Vita S. Salsman Bambi Grilley Adrian Gee Gianpietro Dotti Helen E. Heslop Malcolm K. Brenner Winfried S. Wels Stephen Gottschalk Nabil Ahmed |
| author_sort |
Meenakshi Hegde |
| title |
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma |
| title_short |
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma |
| title_full |
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma |
| title_fullStr |
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma |
| title_full_unstemmed |
Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma |
| title_sort |
tumor response and endogenous immune reactivity after administration of her2 car t cells in a child with metastatic rhabdomyosarcoma |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/924e95c7aec9406f9a123abaaaf5e1e2 |
| work_keys_str_mv |
AT meenakshihegde tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT sujithkjoseph tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT farzanapashankar tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT christopherderenzo tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT khaledsanber tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT shobanavai tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT tiaratbyrd tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT johnhicks tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT minalxu tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT claudiagerken tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT mamtakalra tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT catherinerobertson tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT huiminzhang tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT ankitashree tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT birjumehta tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT olgadakhova tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT vitassalsman tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT bambigrilley tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT adriangee tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT gianpietrodotti tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT heleneheslop tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT malcolmkbrenner tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT winfriedswels tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT stephengottschalk tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma AT nabilahmed tumorresponseandendogenousimmunereactivityafteradministrationofher2cartcellsinachildwithmetastaticrhabdomyosarcoma |
| _version_ |
1718377875784073216 |