Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

The role of nutrient-sensing pathways in regulation of innate immune response is unexplored. Here the authors show that IL-4 activates the amino-acid sensing pathway in macrophages and leads to polarization of anti-inflammatory M2 macrophages via the transcription factor liver X receptor.

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Autores principales:	Tetsuya Kimura, Shigeyuki Nada, Noriko Takegahara, Tatsusada Okuno, Satoshi Nojima, Sujin Kang, Daisuke Ito, Keiko Morimoto, Takashi Hosokawa, Yoshitomo Hayama, Yuichi Mitsui, Natsuki Sakurai, Hana Sarashina-Kida, Masayuki Nishide, Yohei Maeda, Hyota Takamatsu, Daisuke Okuzaki, Masaki Yamada, Masato Okada, Atsushi Kumanogoh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/924eb32133c34310becad7e489a068dc
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spelling	oai:doaj.org-article:924eb32133c34310becad7e489a068dc2021-12-02T17:32:20ZPolarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals10.1038/ncomms131302041-1723https://doaj.org/article/924eb32133c34310becad7e489a068dc2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13130https://doaj.org/toc/2041-1723The role of nutrient-sensing pathways in regulation of innate immune response is unexplored. Here the authors show that IL-4 activates the amino-acid sensing pathway in macrophages and leads to polarization of anti-inflammatory M2 macrophages via the transcription factor liver X receptor.Tetsuya KimuraShigeyuki NadaNoriko TakegaharaTatsusada OkunoSatoshi NojimaSujin KangDaisuke ItoKeiko MorimotoTakashi HosokawaYoshitomo HayamaYuichi MitsuiNatsuki SakuraiHana Sarashina-KidaMasayuki NishideYohei MaedaHyota TakamatsuDaisuke OkuzakiMasaki YamadaMasato OkadaAtsushi KumanogohNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tetsuya Kimura Shigeyuki Nada Noriko Takegahara Tatsusada Okuno Satoshi Nojima Sujin Kang Daisuke Ito Keiko Morimoto Takashi Hosokawa Yoshitomo Hayama Yuichi Mitsui Natsuki Sakurai Hana Sarashina-Kida Masayuki Nishide Yohei Maeda Hyota Takamatsu Daisuke Okuzaki Masaki Yamada Masato Okada Atsushi Kumanogoh Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
description	The role of nutrient-sensing pathways in regulation of innate immune response is unexplored. Here the authors show that IL-4 activates the amino-acid sensing pathway in macrophages and leads to polarization of anti-inflammatory M2 macrophages via the transcription factor liver X receptor.
format	article
author	Tetsuya Kimura Shigeyuki Nada Noriko Takegahara Tatsusada Okuno Satoshi Nojima Sujin Kang Daisuke Ito Keiko Morimoto Takashi Hosokawa Yoshitomo Hayama Yuichi Mitsui Natsuki Sakurai Hana Sarashina-Kida Masayuki Nishide Yohei Maeda Hyota Takamatsu Daisuke Okuzaki Masaki Yamada Masato Okada Atsushi Kumanogoh
author_facet	Tetsuya Kimura Shigeyuki Nada Noriko Takegahara Tatsusada Okuno Satoshi Nojima Sujin Kang Daisuke Ito Keiko Morimoto Takashi Hosokawa Yoshitomo Hayama Yuichi Mitsui Natsuki Sakurai Hana Sarashina-Kida Masayuki Nishide Yohei Maeda Hyota Takamatsu Daisuke Okuzaki Masaki Yamada Masato Okada Atsushi Kumanogoh
author_sort	Tetsuya Kimura
title	Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
title_short	Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
title_full	Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
title_fullStr	Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
title_full_unstemmed	Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals
title_sort	polarization of m2 macrophages requires lamtor1 that integrates cytokine and amino-acid signals
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/924eb32133c34310becad7e489a068dc
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Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals

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