IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation
Th17 cells are a common pathogenic effector cell in autoimmune inflammatory diseases. Here the authors show that the transcription factor RFX1 limits Th17 differentiation and is protective against the pathogenesis of Th17-driven autoimmune diseases.
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Nature Portfolio
2018
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oai:doaj.org-article:924f8474ce9e432faa72f6e2dc5689172021-12-02T17:31:16ZIL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation10.1038/s41467-018-02890-02041-1723https://doaj.org/article/924f8474ce9e432faa72f6e2dc5689172018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02890-0https://doaj.org/toc/2041-1723Th17 cells are a common pathogenic effector cell in autoimmune inflammatory diseases. Here the authors show that the transcription factor RFX1 limits Th17 differentiation and is protective against the pathogenesis of Th17-driven autoimmune diseases.Ming ZhaoYixin TanQiao PengCancan HuangYu GuoGongping LiangBochen ZhuYi HuangAiyun LiuZijun WangMengying LiXiaofei GaoRuifang WuHaijing WuHai LongQianjin LuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q Ming Zhao Yixin Tan Qiao Peng Cancan Huang Yu Guo Gongping Liang Bochen Zhu Yi Huang Aiyun Liu Zijun Wang Mengying Li Xiaofei Gao Ruifang Wu Haijing Wu Hai Long Qianjin Lu IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation |
| description |
Th17 cells are a common pathogenic effector cell in autoimmune inflammatory diseases. Here the authors show that the transcription factor RFX1 limits Th17 differentiation and is protective against the pathogenesis of Th17-driven autoimmune diseases. |
| format |
article |
| author |
Ming Zhao Yixin Tan Qiao Peng Cancan Huang Yu Guo Gongping Liang Bochen Zhu Yi Huang Aiyun Liu Zijun Wang Mengying Li Xiaofei Gao Ruifang Wu Haijing Wu Hai Long Qianjin Lu |
| author_facet |
Ming Zhao Yixin Tan Qiao Peng Cancan Huang Yu Guo Gongping Liang Bochen Zhu Yi Huang Aiyun Liu Zijun Wang Mengying Li Xiaofei Gao Ruifang Wu Haijing Wu Hai Long Qianjin Lu |
| author_sort |
Ming Zhao |
| title |
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation |
| title_short |
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation |
| title_full |
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation |
| title_fullStr |
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation |
| title_full_unstemmed |
IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation |
| title_sort |
il-6/stat3 pathway induced deficiency of rfx1 contributes to th17-dependent autoimmune diseases via epigenetic regulation |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/924f8474ce9e432faa72f6e2dc568917 |
| work_keys_str_mv |
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| _version_ |
1718380685694074880 |