IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation

IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation

Th17 cells are a common pathogenic effector cell in autoimmune inflammatory diseases. Here the authors show that the transcription factor RFX1 limits Th17 differentiation and is protective against the pathogenesis of Th17-driven autoimmune diseases.

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Detalles Bibliográficos
Autores principales: Ming Zhao, Yixin Tan, Qiao Peng, Cancan Huang, Yu Guo, Gongping Liang, Bochen Zhu, Yi Huang, Aiyun Liu, Zijun Wang, Mengying Li, Xiaofei Gao, Ruifang Wu, Haijing Wu, Hai Long, Qianjin Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/924f8474ce9e432faa72f6e2dc568917
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