Identifying disease-associated pathways in one-phenotype data based on reversal gene expression orderings

Abstract Due to the invasiveness nature of tissue biopsy, it is common that investigators cannot collect sufficient normal controls for comparison with diseased samples. We developed a pathway enrichment tool, DRFunc, to detect significantly disease-disrupted pathways by incorporating normal control...

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Autores principales: Guini Hong, Hongdong Li, Jiahui Zhang, Qingzhou Guan, Rou Chen, Zheng Guo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/925220fe34644c3b99eab0ee501c68c8
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