Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings

Objectives: The aim of this study was to calculate the horizontal growth rate of melanoma in vivo and to correlate it with morphologic findings. Patients and Methods: We searched our database for melanomas for which sequential dermatoscopic images and histopathologic slides were available. The f...

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Autores principales:	Jürgen Beer, Lina Xu, Philipp Tschandl, Harald Kittler
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2011
Materias:	horizontal growth rate melanoma in vivo dermatoscopy Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/92533724dd434e67be827f2e89b141fb
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spelling	oai:doaj.org-article:92533724dd434e67be827f2e89b141fb2021-11-17T08:33:21ZGrowth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings10.5826/dpc.0101a132160-9381https://doaj.org/article/92533724dd434e67be827f2e89b141fb2011-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/1140https://doaj.org/toc/2160-9381 Objectives: The aim of this study was to calculate the horizontal growth rate of melanoma in vivo and to correlate it with morphologic findings. Patients and Methods: We searched our database for melanomas for which sequential dermatoscopic images and histopathologic slides were available. The final sample consisted of 50 melanomas of 48 patients (mean age: 50 ± 15 years, 62% females). We calculated the horizontal growth rate in mm2 per year by morphometric analysis of digital dermatoscopic images. Dermatoscopic and dermatopathologic findings were assessed according to predefined criteria and correlated with the horizontal growth rate. Results: The median time interval between baseline and follow-up image was 12 months (range: 2-100 months). The majority of melanomas were in situ (n=28, 56%). The mean horizontal growth rate of all melanomas was 5.3 mm2/year (SD: ± 5.8 mm2/year). The histopathologic findings of numerous and large epidermal nests were associated with rapid growth. This histopathologic pattern corresponded to a pattern of clods (“globules”) dermatoscopically. From a dermatoscopic point of view, melanomas with a main pattern of clods grew significantly faster (mean horizontal growth rate: 10.4 mm2/year, 95% CI: 6.4-14.4 mm2/year) than melanomas with mainly a reticular pattern (4.8 mm2/year, 95% CI: 2.7-7.0 mm2/year) or with other patterns (2.6 mm2/year, 95% CI: -0.5-5.6 mm2/year, p=0.01). Conclusion: Morphologic characteristics of melanoma are associated with biologic behavior. Large and numerous epidermal nests (corresponding to a pattern of clods dermatoscopically) indicate more rapid growth. Jürgen BeerLina XuPhilipp TschandlHarald KittlerMattioli1885articlehorizontal growth ratemelanoma in vivodermatoscopyDermatologyRL1-803ENDermatology Practical & Conceptual (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	horizontal growth rate melanoma in vivo dermatoscopy Dermatology RL1-803
spellingShingle	horizontal growth rate melanoma in vivo dermatoscopy Dermatology RL1-803 Jürgen Beer Lina Xu Philipp Tschandl Harald Kittler Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings
description	Objectives: The aim of this study was to calculate the horizontal growth rate of melanoma in vivo and to correlate it with morphologic findings. Patients and Methods: We searched our database for melanomas for which sequential dermatoscopic images and histopathologic slides were available. The final sample consisted of 50 melanomas of 48 patients (mean age: 50 ± 15 years, 62% females). We calculated the horizontal growth rate in mm2 per year by morphometric analysis of digital dermatoscopic images. Dermatoscopic and dermatopathologic findings were assessed according to predefined criteria and correlated with the horizontal growth rate. Results: The median time interval between baseline and follow-up image was 12 months (range: 2-100 months). The majority of melanomas were in situ (n=28, 56%). The mean horizontal growth rate of all melanomas was 5.3 mm2/year (SD: ± 5.8 mm2/year). The histopathologic findings of numerous and large epidermal nests were associated with rapid growth. This histopathologic pattern corresponded to a pattern of clods (“globules”) dermatoscopically. From a dermatoscopic point of view, melanomas with a main pattern of clods grew significantly faster (mean horizontal growth rate: 10.4 mm2/year, 95% CI: 6.4-14.4 mm2/year) than melanomas with mainly a reticular pattern (4.8 mm2/year, 95% CI: 2.7-7.0 mm2/year) or with other patterns (2.6 mm2/year, 95% CI: -0.5-5.6 mm2/year, p=0.01). Conclusion: Morphologic characteristics of melanoma are associated with biologic behavior. Large and numerous epidermal nests (corresponding to a pattern of clods dermatoscopically) indicate more rapid growth.
format	article
author	Jürgen Beer Lina Xu Philipp Tschandl Harald Kittler
author_facet	Jürgen Beer Lina Xu Philipp Tschandl Harald Kittler
author_sort	Jürgen Beer
title	Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings
title_short	Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings
title_full	Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings
title_fullStr	Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings
title_full_unstemmed	Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings
title_sort	growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings
publisher	Mattioli1885
publishDate	2011
url	https://doaj.org/article/92533724dd434e67be827f2e89b141fb
work_keys_str_mv	AT jurgenbeer growthrateofmelanomainvivoandcorrelationwithdermatoscopicanddermatopathologicfindings AT linaxu growthrateofmelanomainvivoandcorrelationwithdermatoscopicanddermatopathologicfindings AT philipptschandl growthrateofmelanomainvivoandcorrelationwithdermatoscopicanddermatopathologicfindings AT haraldkittler growthrateofmelanomainvivoandcorrelationwithdermatoscopicanddermatopathologicfindings
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Growth rate of melanoma in vivo and correlation with dermatoscopic and dermatopathologic findings

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