Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder

Shao-Wei Xue,1,2 Donglin Wang,1,2 Zhonglin Tan,3 Yan Wang,1,2 Zhenzhen Lian,1,2 Yunkai Sun,1,2 Xiaojiao Hu,1,2 Xiaole Wang,1,2 Xin Zhou1,2 1Center for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People&...

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Autores principales:	Xue SW, Wang D, Tan Z, Wang Y, Lian Z, Sun Y, Hu X, Wang X, Zhou X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Major depressive disorder Entropy Thalamus Functional connectivity Superior frontal gyrus. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/9253845bbfbf4438b7271a1d032dd68a
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spelling	oai:doaj.org-article:9253845bbfbf4438b7271a1d032dd68a2021-12-02T02:32:39ZDisrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder1178-2021https://doaj.org/article/9253845bbfbf4438b7271a1d032dd68a2019-09-01T00:00:00Zhttps://www.dovepress.com/disrupted-brain-entropy-and-functional-connectivity-patterns-of-thalam-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Shao-Wei Xue,1,2 Donglin Wang,1,2 Zhonglin Tan,3 Yan Wang,1,2 Zhenzhen Lian,1,2 Yunkai Sun,1,2 Xiaojiao Hu,1,2 Xiaole Wang,1,2 Xin Zhou1,2 1Center for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People’s Republic of China; 2Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 311121, People’s Republic of China; 3Department of Psychiatry, Hangzhou Seventh People’s Hospital, Hangzhou 310013, People’s Republic of ChinaCorrespondence: Donglin WangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, 2318 Yuhangtang road, Hangzhou, Zhejiang 311121, People’s Republic of ChinaTel +86 571 28867717Fax +86 571 28867717Email wangdl@hznu.edu.cnPurpose: Entropy analysis of resting-state functional magnetic resonance imaging (R-fMRI) has recently been adopted to characterize brain temporal dynamics in some neuropsychological or psychiatric diseases. Thalamus-related dysfunction might be a potential trait marker of major depressive disorder (MDD), but the abnormal changes in the thalamus based on R-fMRI are still unclear from the perspective of brain temporal dynamics. The aim of this study was to identify local entropy changes and subregional connectivity patterns of the thalamus in MDD patients.Patients and methods: We measured the sample entropy of the R-fMRI data from 46 MDD patients and 32 matched healthy controls. We employed the Louvain method for the module detection algorithm to automatically identify a functional parcellation of the thalamus and then examined the whole-brain subregional connectivity patterns.Results: The results indicated that the MDD patients had decreased entropy in the bilateral thalami compared with healthy controls. Increased functional connectivity between the thalamic subregions and the medial part of the superior frontal gyrus (mSFG) was found in MDD patients.Conclusion: This study showed new evidence about sample entropy changes in MDD patients. The functional connectivity alterations that were widely distributed across almost all the thalamic subregions with the mSFG in MDD suggest a general involvement independent of the location and function of the subregions.Keywords: major depressive disorder, entropy, thalamus, functional connectivity, superior frontal gyrusXue SWWang DTan ZWang YLian ZSun YHu XWang XZhou XDove Medical PressarticleMajor depressive disorderEntropyThalamusFunctional connectivitySuperior frontal gyrus.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 2629-2638 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Major depressive disorder Entropy Thalamus Functional connectivity Superior frontal gyrus. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Major depressive disorder Entropy Thalamus Functional connectivity Superior frontal gyrus. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xue SW Wang D Tan Z Wang Y Lian Z Sun Y Hu X Wang X Zhou X Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder
description	Shao-Wei Xue,1,2 Donglin Wang,1,2 Zhonglin Tan,3 Yan Wang,1,2 Zhenzhen Lian,1,2 Yunkai Sun,1,2 Xiaojiao Hu,1,2 Xiaole Wang,1,2 Xin Zhou1,2 1Center for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, Hangzhou 311121, People’s Republic of China; 2Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 311121, People’s Republic of China; 3Department of Psychiatry, Hangzhou Seventh People’s Hospital, Hangzhou 310013, People’s Republic of ChinaCorrespondence: Donglin WangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences and the Affiliated Hospital, Hangzhou Normal University, 2318 Yuhangtang road, Hangzhou, Zhejiang 311121, People’s Republic of ChinaTel +86 571 28867717Fax +86 571 28867717Email wangdl@hznu.edu.cnPurpose: Entropy analysis of resting-state functional magnetic resonance imaging (R-fMRI) has recently been adopted to characterize brain temporal dynamics in some neuropsychological or psychiatric diseases. Thalamus-related dysfunction might be a potential trait marker of major depressive disorder (MDD), but the abnormal changes in the thalamus based on R-fMRI are still unclear from the perspective of brain temporal dynamics. The aim of this study was to identify local entropy changes and subregional connectivity patterns of the thalamus in MDD patients.Patients and methods: We measured the sample entropy of the R-fMRI data from 46 MDD patients and 32 matched healthy controls. We employed the Louvain method for the module detection algorithm to automatically identify a functional parcellation of the thalamus and then examined the whole-brain subregional connectivity patterns.Results: The results indicated that the MDD patients had decreased entropy in the bilateral thalami compared with healthy controls. Increased functional connectivity between the thalamic subregions and the medial part of the superior frontal gyrus (mSFG) was found in MDD patients.Conclusion: This study showed new evidence about sample entropy changes in MDD patients. The functional connectivity alterations that were widely distributed across almost all the thalamic subregions with the mSFG in MDD suggest a general involvement independent of the location and function of the subregions.Keywords: major depressive disorder, entropy, thalamus, functional connectivity, superior frontal gyrus
format	article
author	Xue SW Wang D Tan Z Wang Y Lian Z Sun Y Hu X Wang X Zhou X
author_facet	Xue SW Wang D Tan Z Wang Y Lian Z Sun Y Hu X Wang X Zhou X
author_sort	Xue SW
title	Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder
title_short	Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder
title_full	Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder
title_fullStr	Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder
title_full_unstemmed	Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder
title_sort	disrupted brain entropy and functional connectivity patterns of thalamic subregions in major depressive disorder
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/9253845bbfbf4438b7271a1d032dd68a
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Disrupted Brain Entropy And Functional Connectivity Patterns Of Thalamic Subregions In Major Depressive Disorder

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