IMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS

Abastract. The aim of present study was to evaluate a role of certain key immunoregulatory cytokines, IL-2 and IL-4, in development of disturbed intercellular cooperation of immunocytes during long-term antigenemia in tick-borne encephalitis infection. By means of novel immunological and molecular b...

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Autores principales:	A. P. Zima, N. V. Ryazantseva, V. V. Novitsky, O. B. Zhukova, N. G. Zhukova, A. V. Lepechin, T. T. Radzivil
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	tick-borne encephalitis immunocompetent cells cytokines cytokine receptors Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/92544f51ec9146ae955291259adc0876
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spelling	oai:doaj.org-article:92544f51ec9146ae955291259adc08762021-11-18T08:03:39ZIMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS1563-06252313-741X10.15789/1563-0625-2008-4-5-389-396https://doaj.org/article/92544f51ec9146ae955291259adc08762014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/196https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbastract. The aim of present study was to evaluate a role of certain key immunoregulatory cytokines, IL-2 and IL-4, in development of disturbed intercellular cooperation of immunocytes during long-term antigenemia in tick-borne encephalitis infection. By means of novel immunological and molecular biology testing techniques, an imbalance in production and reception of Th1- and Th2-cytokines (resp., IL-2 and IL-4) by mononuclear leukocytes from peripheral blood towards Th2 response was found in cases of prolonged tick-borne encephalitis viral antigenemia. The study has revealed that, when analyzing effects of IL-4 gene polymorphisms upon predisposition to longer persistence of tick-borne encephalitis virus, there is necessary to observe both promoter allelic variants of IL-4 genes, and polymorphisms of appropriate cytokine receptor genes. (Med. Immunol., vol. 10, N 4-5, pp 389-396).A. P. ZimaN. V. RyazantsevaV. V. NovitskyO. B. ZhukovaN. G. ZhukovaA. V. LepechinT. T. RadzivilSPb RAACIarticletick-borne encephalitisimmunocompetent cellscytokinescytokine receptorsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 389-396 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	tick-borne encephalitis immunocompetent cells cytokines cytokine receptors Immunologic diseases. Allergy RC581-607
spellingShingle	tick-borne encephalitis immunocompetent cells cytokines cytokine receptors Immunologic diseases. Allergy RC581-607 A. P. Zima N. V. Ryazantseva V. V. Novitsky O. B. Zhukova N. G. Zhukova A. V. Lepechin T. T. Radzivil IMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS
description	Abastract. The aim of present study was to evaluate a role of certain key immunoregulatory cytokines, IL-2 and IL-4, in development of disturbed intercellular cooperation of immunocytes during long-term antigenemia in tick-borne encephalitis infection. By means of novel immunological and molecular biology testing techniques, an imbalance in production and reception of Th1- and Th2-cytokines (resp., IL-2 and IL-4) by mononuclear leukocytes from peripheral blood towards Th2 response was found in cases of prolonged tick-borne encephalitis viral antigenemia. The study has revealed that, when analyzing effects of IL-4 gene polymorphisms upon predisposition to longer persistence of tick-borne encephalitis virus, there is necessary to observe both promoter allelic variants of IL-4 genes, and polymorphisms of appropriate cytokine receptor genes. (Med. Immunol., vol. 10, N 4-5, pp 389-396).
format	article
author	A. P. Zima N. V. Ryazantseva V. V. Novitsky O. B. Zhukova N. G. Zhukova A. V. Lepechin T. T. Radzivil
author_facet	A. P. Zima N. V. Ryazantseva V. V. Novitsky O. B. Zhukova N. G. Zhukova A. V. Lepechin T. T. Radzivil
author_sort	A. P. Zima
title	IMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS
title_short	IMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS
title_full	IMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS
title_fullStr	IMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS
title_full_unstemmed	IMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS
title_sort	imbalance in il-2 and il-4 production and reception during prolonged viral antigenemia in tick-born encephalitis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/92544f51ec9146ae955291259adc0876
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IMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS

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