Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

The pathogenesis of osteoarthritis is unclear. The authors show that estrogen-related receptor gamma is upregulated in cartilage from patients and mouse models, where it drives production of matrix-degrading MMPs in chondrocytes, and that its downregulation ameliorates pathology in mice.

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Autores principales:	Young-Ok Son, Seulki Park, Ji-Sun Kwak, Yoonkyung Won, Wan-Su Choi, Jinseol Rhee, Churl-Hong Chun, Je-Hwang Ryu, Don-Kyu Kim, Hueng-Sik Choi, Jang-Soo Chun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9254846d1474425a872f6973f8da6d1c
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spelling	oai:doaj.org-article:9254846d1474425a872f6973f8da6d1c2021-12-02T14:42:11ZEstrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes10.1038/s41467-017-01868-82041-1723https://doaj.org/article/9254846d1474425a872f6973f8da6d1c2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01868-8https://doaj.org/toc/2041-1723The pathogenesis of osteoarthritis is unclear. The authors show that estrogen-related receptor gamma is upregulated in cartilage from patients and mouse models, where it drives production of matrix-degrading MMPs in chondrocytes, and that its downregulation ameliorates pathology in mice.Young-Ok SonSeulki ParkJi-Sun KwakYoonkyung WonWan-Su ChoiJinseol RheeChurl-Hong ChunJe-Hwang RyuDon-Kyu KimHueng-Sik ChoiJang-Soo ChunNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Young-Ok Son Seulki Park Ji-Sun Kwak Yoonkyung Won Wan-Su Choi Jinseol Rhee Churl-Hong Chun Je-Hwang Ryu Don-Kyu Kim Hueng-Sik Choi Jang-Soo Chun Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes
description	The pathogenesis of osteoarthritis is unclear. The authors show that estrogen-related receptor gamma is upregulated in cartilage from patients and mouse models, where it drives production of matrix-degrading MMPs in chondrocytes, and that its downregulation ameliorates pathology in mice.
format	article
author	Young-Ok Son Seulki Park Ji-Sun Kwak Yoonkyung Won Wan-Su Choi Jinseol Rhee Churl-Hong Chun Je-Hwang Ryu Don-Kyu Kim Hueng-Sik Choi Jang-Soo Chun
author_facet	Young-Ok Son Seulki Park Ji-Sun Kwak Yoonkyung Won Wan-Su Choi Jinseol Rhee Churl-Hong Chun Je-Hwang Ryu Don-Kyu Kim Hueng-Sik Choi Jang-Soo Chun
author_sort	Young-Ok Son
title	Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes
title_short	Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes
title_full	Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes
title_fullStr	Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes
title_full_unstemmed	Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes
title_sort	estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/9254846d1474425a872f6973f8da6d1c
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Estrogen-related receptor γ causes osteoarthritis by upregulating extracellular matrix-degrading enzymes

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