BOLD specificity and dynamics evaluated in humans at 7 T: comparing gradient-echo and spin-echo hemodynamic responses.

High-field gradient-echo (GE) BOLD fMRI enables very high resolution imaging, and has great potential for detailed investigations of brain function. However, as spatial resolution increases, confounds due to signal from non-capillary vessels increasingly impact the fidelity of GE BOLD fMRI signals....

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Autores principales:	Jeroen C W Siero, Nick F Ramsey, Hans Hoogduin, Dennis W J Klomp, Peter R Luijten, Natalia Petridou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/925c755736804ead953c40ecc80f3179
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spelling	oai:doaj.org-article:925c755736804ead953c40ecc80f31792021-11-18T08:01:22ZBOLD specificity and dynamics evaluated in humans at 7 T: comparing gradient-echo and spin-echo hemodynamic responses.1932-620310.1371/journal.pone.0054560https://doaj.org/article/925c755736804ead953c40ecc80f31792013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23336008/?tool=EBIhttps://doaj.org/toc/1932-6203High-field gradient-echo (GE) BOLD fMRI enables very high resolution imaging, and has great potential for detailed investigations of brain function. However, as spatial resolution increases, confounds due to signal from non-capillary vessels increasingly impact the fidelity of GE BOLD fMRI signals. Here we report on an assessment of the microvascular weighting of the GE BOLD response across the cortical depth in human cortex using spin-echo fMRI which is thought to be dominated by microvasculature (albeit not completely). BOLD responses were measured with a hemodynamic impulse response (HRF) obtained from the spin-echo (SE) and gradient-echo (GE) BOLD contrast using very short stimuli (0.25 s) and a fast event-related functional paradigm. We show that the onset (≈ 1.25 s) and the rising slope of the GE and SE HRFs are strikingly similar for voxels in deep gray matter presumably containing the most metabolically demanding neurons (layers III-IV). This finding provides a strong indication that the onset of the GE HRF in deep gray matter is predominantly associated with microvasculature.Jeroen C W SieroNick F RamseyHans HoogduinDennis W J KlompPeter R LuijtenNatalia PetridouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e54560 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeroen C W Siero Nick F Ramsey Hans Hoogduin Dennis W J Klomp Peter R Luijten Natalia Petridou BOLD specificity and dynamics evaluated in humans at 7 T: comparing gradient-echo and spin-echo hemodynamic responses.
description	High-field gradient-echo (GE) BOLD fMRI enables very high resolution imaging, and has great potential for detailed investigations of brain function. However, as spatial resolution increases, confounds due to signal from non-capillary vessels increasingly impact the fidelity of GE BOLD fMRI signals. Here we report on an assessment of the microvascular weighting of the GE BOLD response across the cortical depth in human cortex using spin-echo fMRI which is thought to be dominated by microvasculature (albeit not completely). BOLD responses were measured with a hemodynamic impulse response (HRF) obtained from the spin-echo (SE) and gradient-echo (GE) BOLD contrast using very short stimuli (0.25 s) and a fast event-related functional paradigm. We show that the onset (≈ 1.25 s) and the rising slope of the GE and SE HRFs are strikingly similar for voxels in deep gray matter presumably containing the most metabolically demanding neurons (layers III-IV). This finding provides a strong indication that the onset of the GE HRF in deep gray matter is predominantly associated with microvasculature.
format	article
author	Jeroen C W Siero Nick F Ramsey Hans Hoogduin Dennis W J Klomp Peter R Luijten Natalia Petridou
author_facet	Jeroen C W Siero Nick F Ramsey Hans Hoogduin Dennis W J Klomp Peter R Luijten Natalia Petridou
author_sort	Jeroen C W Siero
title	BOLD specificity and dynamics evaluated in humans at 7 T: comparing gradient-echo and spin-echo hemodynamic responses.
title_short	BOLD specificity and dynamics evaluated in humans at 7 T: comparing gradient-echo and spin-echo hemodynamic responses.
title_full	BOLD specificity and dynamics evaluated in humans at 7 T: comparing gradient-echo and spin-echo hemodynamic responses.
title_fullStr	BOLD specificity and dynamics evaluated in humans at 7 T: comparing gradient-echo and spin-echo hemodynamic responses.
title_full_unstemmed	BOLD specificity and dynamics evaluated in humans at 7 T: comparing gradient-echo and spin-echo hemodynamic responses.
title_sort	bold specificity and dynamics evaluated in humans at 7 t: comparing gradient-echo and spin-echo hemodynamic responses.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/925c755736804ead953c40ecc80f3179
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BOLD specificity and dynamics evaluated in humans at 7 T: comparing gradient-echo and spin-echo hemodynamic responses.

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