ROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION
Abstract. Expression of endocannabinoid receptors (СВ1, СВ2) in immunocompetent cells was studied under the conditions of in vivo stimulation of immune system. Intracorporeal blood irradiation and enrichment of peripheral blood by ozone/oxygen mixture were used to stimulate immune system. It was rev...
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SPb RAACI
2014
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oai:doaj.org-article:925e57fa3a644bfca7196845169cce572021-11-18T08:03:40ZROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION1563-06252313-741X10.15789/1563-0625-2012-3-189-194https://doaj.org/article/925e57fa3a644bfca7196845169cce572014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/345https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Expression of endocannabinoid receptors (СВ1, СВ2) in immunocompetent cells was studied under the conditions of in vivo stimulation of immune system. Intracorporeal blood irradiation and enrichment of peripheral blood by ozone/oxygen mixture were used to stimulate immune system. It was revealed that normal amounts of mononuclear leukocytes (MLs) expressing a differentiating surface antigen for СВ2 receptor exceeded 90%. We have not detected MLs with a differentiating antigen to СВ1 receptor. In vivo stimulation of immune system caused a suppressed endocannabinoid СВ2 receptor expression on ML surface. The data provide a direct proof for involvement of endocannabinoid system in immune response regulation.E. G. LobanovaSPb RAACIarticlemononuclear leukocytesсв1 and св2 endocannabinoid receptorsimmune responseImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 3, Pp 189-194 (2014) |
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DOAJ |
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DOAJ |
| language |
RU |
| topic |
mononuclear leukocytes св1 and св2 endocannabinoid receptors immune response Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
mononuclear leukocytes св1 and св2 endocannabinoid receptors immune response Immunologic diseases. Allergy RC581-607 E. G. Lobanova ROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION |
| description |
Abstract. Expression of endocannabinoid receptors (СВ1, СВ2) in immunocompetent cells was studied under the conditions of in vivo stimulation of immune system. Intracorporeal blood irradiation and enrichment of peripheral blood by ozone/oxygen mixture were used to stimulate immune system. It was revealed that normal amounts of mononuclear leukocytes (MLs) expressing a differentiating surface antigen for СВ2 receptor exceeded 90%. We have not detected MLs with a differentiating antigen to СВ1 receptor. In vivo stimulation of immune system caused a suppressed endocannabinoid СВ2 receptor expression on ML surface. The data provide a direct proof for involvement of endocannabinoid system in immune response regulation. |
| format |
article |
| author |
E. G. Lobanova |
| author_facet |
E. G. Lobanova |
| author_sort |
E. G. Lobanova |
| title |
ROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION |
| title_short |
ROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION |
| title_full |
ROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION |
| title_fullStr |
ROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION |
| title_full_unstemmed |
ROLE OF ENDOCANNABINOID RECEPTORS IN IMMUNE RESPONSE REGULATION |
| title_sort |
role of endocannabinoid receptors in immune response regulation |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/925e57fa3a644bfca7196845169cce57 |
| work_keys_str_mv |
AT eglobanova roleofendocannabinoidreceptorsinimmuneresponseregulation |
| _version_ |
1718422492686581760 |