Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis

In knee osteoarthritis (KOA), synovial inflammation is linked with pain, swelling and structural abnormalities. Intra-articular corticosteroids (IACS) have been considered for pain relief in subjects who are non-responders to standard therapy. However, the results vary across different studies. This...

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Autores principales:	Parnaz Heidari, Behzad Heidari, Mansour Babaei
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2020
Materias:	knee osteoarthritis intra-articular corticosteroid synovitis pain efficacy predictor. Medicine R
Acceso en línea:	https://doaj.org/article/92670978a57a42dcbac1f0d0bfe8b016
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spelling	oai:doaj.org-article:92670978a57a42dcbac1f0d0bfe8b0162021-12-02T19:19:13ZEfficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis0034-62332084-983410.5114/reum.2020.102008https://doaj.org/article/92670978a57a42dcbac1f0d0bfe8b0162020-12-01T00:00:00Zhttps://www.termedia.pl/Efficacy-and-predictive-factors-of-response-to-intra-articular-corticosteroids-in-knee-osteoarthritis,18,42777,1,1.htmlhttps://doaj.org/toc/0034-6233https://doaj.org/toc/2084-9834In knee osteoarthritis (KOA), synovial inflammation is linked with pain, swelling and structural abnormalities. Intra-articular corticosteroids (IACS) have been considered for pain relief in subjects who are non-responders to standard therapy. However, the results vary across different studies. This review aims to determine efficacy of IACS in KOA by review of the existing data. In several randomized controlled trials (RCTs), meta-analyses and uncontrolled studies a single IACS resulted in pain relief from 1 to a few weeks. In a few studies repeated IACS every three months provided a longer duration of pain relief and functional improvement in a proportion of patients. Baseline synovitis was predictor of treatment response in some but not all studies. Based upon the existing data, IACS provides a short-term pain relief in a proportion of patients. Given, anti-inflammatory properties of IACS, it is likely to be more effective in subgroups of KOA who display inflammatory phenotype.Parnaz HeidariBehzad HeidariMansour BabaeiTermedia Publishing Housearticleknee osteoarthritis intra-articular corticosteroid synovitis pain efficacy predictor.MedicineRENRheumatology, Vol 58, Iss 6, Pp 424-435 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	knee osteoarthritis intra-articular corticosteroid synovitis pain efficacy predictor. Medicine R
spellingShingle	knee osteoarthritis intra-articular corticosteroid synovitis pain efficacy predictor. Medicine R Parnaz Heidari Behzad Heidari Mansour Babaei Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis
description	In knee osteoarthritis (KOA), synovial inflammation is linked with pain, swelling and structural abnormalities. Intra-articular corticosteroids (IACS) have been considered for pain relief in subjects who are non-responders to standard therapy. However, the results vary across different studies. This review aims to determine efficacy of IACS in KOA by review of the existing data. In several randomized controlled trials (RCTs), meta-analyses and uncontrolled studies a single IACS resulted in pain relief from 1 to a few weeks. In a few studies repeated IACS every three months provided a longer duration of pain relief and functional improvement in a proportion of patients. Baseline synovitis was predictor of treatment response in some but not all studies. Based upon the existing data, IACS provides a short-term pain relief in a proportion of patients. Given, anti-inflammatory properties of IACS, it is likely to be more effective in subgroups of KOA who display inflammatory phenotype.
format	article
author	Parnaz Heidari Behzad Heidari Mansour Babaei
author_facet	Parnaz Heidari Behzad Heidari Mansour Babaei
author_sort	Parnaz Heidari
title	Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis
title_short	Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis
title_full	Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis
title_fullStr	Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis
title_full_unstemmed	Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis
title_sort	efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis
publisher	Termedia Publishing House
publishDate	2020
url	https://doaj.org/article/92670978a57a42dcbac1f0d0bfe8b016
work_keys_str_mv	AT parnazheidari efficacyandpredictivefactorsofresponsetointraarticularcorticosteroidsinkneeosteoarthritis AT behzadheidari efficacyandpredictivefactorsofresponsetointraarticularcorticosteroidsinkneeosteoarthritis AT mansourbabaei efficacyandpredictivefactorsofresponsetointraarticularcorticosteroidsinkneeosteoarthritis
_version_	1718376865334296576

Efficacy and predictive factors of response to intra-articular corticosteroids in knee osteoarthritis

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