Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.

Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is of zoonotic origin. Evolutionary analyses assessing whether coronaviruses similar to SARS-CoV-2 infected ancestral species of modern-day animal hosts could be useful in identifying additional reservoirs of poten...

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Autores principales:	Sean B King, Mona Singh
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/9267debb6d424d06aece8bf90b14ee2a
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spelling	oai:doaj.org-article:9267debb6d424d06aece8bf90b14ee2a2021-12-02T19:58:11ZComparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.1553-734X1553-735810.1371/journal.pcbi.1009560https://doaj.org/article/9267debb6d424d06aece8bf90b14ee2a2021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009560https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is of zoonotic origin. Evolutionary analyses assessing whether coronaviruses similar to SARS-CoV-2 infected ancestral species of modern-day animal hosts could be useful in identifying additional reservoirs of potentially dangerous coronaviruses. We reasoned that if a clade of species has been repeatedly exposed to a virus, then their proteins relevant for viral entry may exhibit adaptations that affect host susceptibility or response. We perform comparative analyses across the mammalian phylogeny of angiotensin-converting enzyme 2 (ACE2), the cellular receptor for SARS-CoV-2, in order to uncover evidence for selection acting at its binding interface with the SARS-CoV-2 spike protein. We uncover that in rodents there is evidence for adaptive amino acid substitutions at positions comprising the ACE2-spike interaction interface, whereas the variation within ACE2 proteins in primates and some other mammalian clades is not consistent with evolutionary adaptations. We also analyze aminopeptidase N (APN), the receptor for the human coronavirus 229E, a virus that causes the common cold, and find evidence for adaptation in primates. Altogether, our results suggest that the rodent and primate lineages may have had ancient exposures to viruses similar to SARS-CoV-2 and HCoV-229E, respectively.Sean B KingMona SinghPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 11, p e1009560 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Sean B King Mona Singh Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.
description	Severe acute respiratory coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, is of zoonotic origin. Evolutionary analyses assessing whether coronaviruses similar to SARS-CoV-2 infected ancestral species of modern-day animal hosts could be useful in identifying additional reservoirs of potentially dangerous coronaviruses. We reasoned that if a clade of species has been repeatedly exposed to a virus, then their proteins relevant for viral entry may exhibit adaptations that affect host susceptibility or response. We perform comparative analyses across the mammalian phylogeny of angiotensin-converting enzyme 2 (ACE2), the cellular receptor for SARS-CoV-2, in order to uncover evidence for selection acting at its binding interface with the SARS-CoV-2 spike protein. We uncover that in rodents there is evidence for adaptive amino acid substitutions at positions comprising the ACE2-spike interaction interface, whereas the variation within ACE2 proteins in primates and some other mammalian clades is not consistent with evolutionary adaptations. We also analyze aminopeptidase N (APN), the receptor for the human coronavirus 229E, a virus that causes the common cold, and find evidence for adaptation in primates. Altogether, our results suggest that the rodent and primate lineages may have had ancient exposures to viruses similar to SARS-CoV-2 and HCoV-229E, respectively.
format	article
author	Sean B King Mona Singh
author_facet	Sean B King Mona Singh
author_sort	Sean B King
title	Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.
title_short	Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.
title_full	Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.
title_fullStr	Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.
title_full_unstemmed	Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.
title_sort	comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/9267debb6d424d06aece8bf90b14ee2a
work_keys_str_mv	AT seanbking comparativegenomicanalysisrevealsvaryinglevelsofmammalianadaptationtocoronavirusinfections AT monasingh comparativegenomicanalysisrevealsvaryinglevelsofmammalianadaptationtocoronavirusinfections
_version_	1718375790753611776

Comparative genomic analysis reveals varying levels of mammalian adaptation to coronavirus infections.

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