THE FEATURES OF SURFACE PHENOTYPE OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH TUBERCULOSIS
Abstract. Parameters of peripheral blood lymphocytes subpopulations have been studies in the patients with extensive destructive pulmonary tuberculosis caused by drug-sensitive or drug-resistant Mycobacterium tuberculosis before and in the course of specific anti-tuberculosis chemotherapy. It was re...
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oai:doaj.org-article:926a860207cd48568ec6096ebadb60322021-11-18T08:03:43ZTHE FEATURES OF SURFACE PHENOTYPE OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2005-5-6-587-592https://doaj.org/article/926a860207cd48568ec6096ebadb60322014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/634https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Parameters of peripheral blood lymphocytes subpopulations have been studies in the patients with extensive destructive pulmonary tuberculosis caused by drug-sensitive or drug-resistant Mycobacterium tuberculosis before and in the course of specific anti-tuberculosis chemotherapy. It was revealed that in the patients before treatment, a marked immunosuppression takes place, being characterized by decrease of total T-lymphocytes and their basic regulatory and effector subpopulations. E.e., an increase in CD20+-, CD25+- and CD95+cells was observed. The completion of intensive anti-tuberculosis chemotherapy is not accompanied by correction of lymphocyte subpopulations. By contrary, in the patients with drug-sensitive pulmonary tuberculosis M. tuberculosis a sharp increase in CD95+-lymphocytes is registered. After undergoing a full course of therapy a well-noted tendency to normalization of T-lymphocytes (CD3+) quantity, as well as is regulatory populations (CD4+ and CD8+) were found. The level of CD95+-lymphocytes remained increased in the patients with pulmonary tuberculosis caused by drug-resistant M. tuberculosis.V. V. NovickyA. K. StrelisO. I. UrazovaO. V. VoronkovaV. A. SinitsinaS. B. TkachenkoO. V. FiliniukN. A. ZemlianayaT. A. Shil’koI. Ye. EsimovaSPb RAACIarticletuberculosisdrug-resistant strainsdrug-sensitive strainslymphocyteslymphocytes subpopulationsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 5-6, Pp 587-592 (2014) |
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DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
tuberculosis drug-resistant strains drug-sensitive strains lymphocytes lymphocytes subpopulations Immunologic diseases. Allergy RC581-607 |
| spellingShingle |
tuberculosis drug-resistant strains drug-sensitive strains lymphocytes lymphocytes subpopulations Immunologic diseases. Allergy RC581-607 V. V. Novicky A. K. Strelis O. I. Urazova O. V. Voronkova V. A. Sinitsina S. B. Tkachenko O. V. Filiniuk N. A. Zemlianaya T. A. Shil’ko I. Ye. Esimova THE FEATURES OF SURFACE PHENOTYPE OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH TUBERCULOSIS |
| description |
Abstract. Parameters of peripheral blood lymphocytes subpopulations have been studies in the patients with extensive destructive pulmonary tuberculosis caused by drug-sensitive or drug-resistant Mycobacterium tuberculosis before and in the course of specific anti-tuberculosis chemotherapy. It was revealed that in the patients before treatment, a marked immunosuppression takes place, being characterized by decrease of total T-lymphocytes and their basic regulatory and effector subpopulations. E.e., an increase in CD20+-, CD25+- and CD95+cells was observed. The completion of intensive anti-tuberculosis chemotherapy is not accompanied by correction of lymphocyte subpopulations. By contrary, in the patients with drug-sensitive pulmonary tuberculosis M. tuberculosis a sharp increase in CD95+-lymphocytes is registered. After undergoing a full course of therapy a well-noted tendency to normalization of T-lymphocytes (CD3+) quantity, as well as is regulatory populations (CD4+ and CD8+) were found. The level of CD95+-lymphocytes remained increased in the patients with pulmonary tuberculosis caused by drug-resistant M. tuberculosis. |
| format |
article |
| author |
V. V. Novicky A. K. Strelis O. I. Urazova O. V. Voronkova V. A. Sinitsina S. B. Tkachenko O. V. Filiniuk N. A. Zemlianaya T. A. Shil’ko I. Ye. Esimova |
| author_facet |
V. V. Novicky A. K. Strelis O. I. Urazova O. V. Voronkova V. A. Sinitsina S. B. Tkachenko O. V. Filiniuk N. A. Zemlianaya T. A. Shil’ko I. Ye. Esimova |
| author_sort |
V. V. Novicky |
| title |
THE FEATURES OF SURFACE PHENOTYPE OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH TUBERCULOSIS |
| title_short |
THE FEATURES OF SURFACE PHENOTYPE OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH TUBERCULOSIS |
| title_full |
THE FEATURES OF SURFACE PHENOTYPE OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH TUBERCULOSIS |
| title_fullStr |
THE FEATURES OF SURFACE PHENOTYPE OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH TUBERCULOSIS |
| title_full_unstemmed |
THE FEATURES OF SURFACE PHENOTYPE OF BLOOD LYMPHOCYTES IN THE PATIENTS WITH TUBERCULOSIS |
| title_sort |
features of surface phenotype of blood lymphocytes in the patients with tuberculosis |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/926a860207cd48568ec6096ebadb6032 |
| work_keys_str_mv |
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