Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy

Usama M Alkholy,1 Nermin Abdalmonem,1 Ahmed Zaki,2 Yasser F Ali,1 Soma Abdalla Mohamed,3 Nasser I Abdelsalam,1 Mustafa Ismail Abu Hashim,1 Mohamed Abou Sekkien,3 Yasser Makram Elsherbiny4 1Pediatric Department, Zagazig University, Egypt; 2Pediatric Department, Mansoura University, Egypt; 3Pediatric...

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Autores principales:	Alkholy UM, Abdalmonem N, Zaki A, Ali YF, Mohamed SA, Abdelsalam NI, Abu Hashim MI, Abou Sekkien M, Elsherbiny YM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Newborn Hypoxic ischemic encephalopathy Serum CK-BB Urinary lactate/creatinine ratio Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/926bb652540444649267ea800832a348
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spelling	oai:doaj.org-article:926bb652540444649267ea800832a3482021-12-02T03:42:02ZEarly predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy1178-2021https://doaj.org/article/926bb652540444649267ea800832a3482017-08-01T00:00:00Zhttps://www.dovepress.com/early-predictors-of-brain-damage-in-full-term-newborns-with-hypoxic-is-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Usama M Alkholy,1 Nermin Abdalmonem,1 Ahmed Zaki,2 Yasser F Ali,1 Soma Abdalla Mohamed,3 Nasser I Abdelsalam,1 Mustafa Ismail Abu Hashim,1 Mohamed Abou Sekkien,3 Yasser Makram Elsherbiny4 1Pediatric Department, Zagazig University, Egypt; 2Pediatric Department, Mansoura University, Egypt; 3Pediatric Department, Al Azhar University, Egypt; 4Clinical Pathology Department, Menoufia University, Egypt Objective of the study: To evaluate the value of serum creatine phosphokinase-brain specific (CK-BB) and urinary lactate/creatinine (L/C) ratio as early indicators of brain damage in full-term newborns with hypoxic ischemic encephalopathy (HIE).Patients and methods: A case–control study including 25 full-term new-born infants with perinatal asphyxia who were admitted to neonatal intensive care unit (NICU) with a proven diagnosis of HIE, compared to 20 healthy age- and sex-matched full-term newborns. All newborn infants were subjected to full history taking, clinical examination, routine investigations (cord blood gases and complete blood picture), and assessment of serum CK-BB (cord blood, 6 and 24 hours after birth) and urinary L/C ratio (collected within the first 6 hours, on the 2nd and 3rd day after birth).Results: The serum CK-BB and urinary L/C ratio in infants with HIE were significantly higher in samples collected throughout the monitoring period when compared with the control group (all P<0.001). The cord CK-BB and urinary L/C ratio within the first 6 hours were significantly higher in infants with severe HIE than in infants with mild and moderate HIE (P<0.001). Cord CK-BB level at 12.5 U/L had 100% sensitivity and 84% specificity in the detection of severe HIE infants. Urinary L/C ratio of more than 10.5 collected within the first 6 hours after birth had 100% sensitivity and 78% specificity for the detection of severe HIE infants.Conclusion: The serum CK-BB and urinary L/C ratio in HIE infants were significantly increased early in the course of the disease, which can be used as useful indicators for predicting the development of HIE. Keywords: hypoxic ischemic encephalopathy, biomarkers, urinary lactate, serum CKBB, neonatal morbidityAlkholy UMAbdalmonem NZaki AAli YFMohamed SAAbdelsalam NIAbu Hashim MIAbou Sekkien MElsherbiny YMDove Medical PressarticleNewbornHypoxic ischemic encephalopathySerum CK-BBUrinary lactate/creatinine ratioNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2133-2139 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Newborn Hypoxic ischemic encephalopathy Serum CK-BB Urinary lactate/creatinine ratio Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Newborn Hypoxic ischemic encephalopathy Serum CK-BB Urinary lactate/creatinine ratio Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Alkholy UM Abdalmonem N Zaki A Ali YF Mohamed SA Abdelsalam NI Abu Hashim MI Abou Sekkien M Elsherbiny YM Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy
description	Usama M Alkholy,1 Nermin Abdalmonem,1 Ahmed Zaki,2 Yasser F Ali,1 Soma Abdalla Mohamed,3 Nasser I Abdelsalam,1 Mustafa Ismail Abu Hashim,1 Mohamed Abou Sekkien,3 Yasser Makram Elsherbiny4 1Pediatric Department, Zagazig University, Egypt; 2Pediatric Department, Mansoura University, Egypt; 3Pediatric Department, Al Azhar University, Egypt; 4Clinical Pathology Department, Menoufia University, Egypt Objective of the study: To evaluate the value of serum creatine phosphokinase-brain specific (CK-BB) and urinary lactate/creatinine (L/C) ratio as early indicators of brain damage in full-term newborns with hypoxic ischemic encephalopathy (HIE).Patients and methods: A case–control study including 25 full-term new-born infants with perinatal asphyxia who were admitted to neonatal intensive care unit (NICU) with a proven diagnosis of HIE, compared to 20 healthy age- and sex-matched full-term newborns. All newborn infants were subjected to full history taking, clinical examination, routine investigations (cord blood gases and complete blood picture), and assessment of serum CK-BB (cord blood, 6 and 24 hours after birth) and urinary L/C ratio (collected within the first 6 hours, on the 2nd and 3rd day after birth).Results: The serum CK-BB and urinary L/C ratio in infants with HIE were significantly higher in samples collected throughout the monitoring period when compared with the control group (all P<0.001). The cord CK-BB and urinary L/C ratio within the first 6 hours were significantly higher in infants with severe HIE than in infants with mild and moderate HIE (P<0.001). Cord CK-BB level at 12.5 U/L had 100% sensitivity and 84% specificity in the detection of severe HIE infants. Urinary L/C ratio of more than 10.5 collected within the first 6 hours after birth had 100% sensitivity and 78% specificity for the detection of severe HIE infants.Conclusion: The serum CK-BB and urinary L/C ratio in HIE infants were significantly increased early in the course of the disease, which can be used as useful indicators for predicting the development of HIE. Keywords: hypoxic ischemic encephalopathy, biomarkers, urinary lactate, serum CKBB, neonatal morbidity
format	article
author	Alkholy UM Abdalmonem N Zaki A Ali YF Mohamed SA Abdelsalam NI Abu Hashim MI Abou Sekkien M Elsherbiny YM
author_facet	Alkholy UM Abdalmonem N Zaki A Ali YF Mohamed SA Abdelsalam NI Abu Hashim MI Abou Sekkien M Elsherbiny YM
author_sort	Alkholy UM
title	Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy
title_short	Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy
title_full	Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy
title_fullStr	Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy
title_full_unstemmed	Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy
title_sort	early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/926bb652540444649267ea800832a348
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Early predictors of brain damage in full-term newborns with hypoxic ischemic encephalopathy

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