Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling

The mechanistic link between metabolic stress and associated cardiomyopathy is unknown. Here the authors show that high fat diet causes calpain-1-dependent degradation of ERK5 leading to mitochondrial dysfunction, suggesting the maintenance of cardiac ERK5 as a therapeutic approach for cardiomyopath...

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Autores principales:	Wei Liu, Andrea Ruiz-Velasco, Shoubao Wang, Saba Khan, Min Zi, Andreas Jungmann, Maria Dolores Camacho-Muñoz, Jing Guo, Guanhua Du, Liping Xie, Delvac Oceandy, Anna Nicolaou, Gina Galli, Oliver J. Müller, Elizabeth J. Cartwright, Yong Ji, Xin Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/926e439022bd4f939e69961ae2ca1b23
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spelling	oai:doaj.org-article:926e439022bd4f939e69961ae2ca1b232021-12-02T14:42:33ZMetabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling10.1038/s41467-017-00664-82041-1723https://doaj.org/article/926e439022bd4f939e69961ae2ca1b232017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00664-8https://doaj.org/toc/2041-1723The mechanistic link between metabolic stress and associated cardiomyopathy is unknown. Here the authors show that high fat diet causes calpain-1-dependent degradation of ERK5 leading to mitochondrial dysfunction, suggesting the maintenance of cardiac ERK5 as a therapeutic approach for cardiomyopathy prevention and/or treatment.Wei LiuAndrea Ruiz-VelascoShoubao WangSaba KhanMin ZiAndreas JungmannMaria Dolores Camacho-MuñozJing GuoGuanhua DuLiping XieDelvac OceandyAnna NicolaouGina GalliOliver J. MüllerElizabeth J. CartwrightYong JiXin WangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wei Liu Andrea Ruiz-Velasco Shoubao Wang Saba Khan Min Zi Andreas Jungmann Maria Dolores Camacho-Muñoz Jing Guo Guanhua Du Liping Xie Delvac Oceandy Anna Nicolaou Gina Galli Oliver J. Müller Elizabeth J. Cartwright Yong Ji Xin Wang Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling
description	The mechanistic link between metabolic stress and associated cardiomyopathy is unknown. Here the authors show that high fat diet causes calpain-1-dependent degradation of ERK5 leading to mitochondrial dysfunction, suggesting the maintenance of cardiac ERK5 as a therapeutic approach for cardiomyopathy prevention and/or treatment.
format	article
author	Wei Liu Andrea Ruiz-Velasco Shoubao Wang Saba Khan Min Zi Andreas Jungmann Maria Dolores Camacho-Muñoz Jing Guo Guanhua Du Liping Xie Delvac Oceandy Anna Nicolaou Gina Galli Oliver J. Müller Elizabeth J. Cartwright Yong Ji Xin Wang
author_facet	Wei Liu Andrea Ruiz-Velasco Shoubao Wang Saba Khan Min Zi Andreas Jungmann Maria Dolores Camacho-Muñoz Jing Guo Guanhua Du Liping Xie Delvac Oceandy Anna Nicolaou Gina Galli Oliver J. Müller Elizabeth J. Cartwright Yong Ji Xin Wang
author_sort	Wei Liu
title	Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling
title_short	Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling
title_full	Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling
title_fullStr	Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling
title_full_unstemmed	Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling
title_sort	metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated erk5 signaling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/926e439022bd4f939e69961ae2ca1b23
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Metabolic stress-induced cardiomyopathy is caused by mitochondrial dysfunction due to attenuated Erk5 signaling

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