3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents
Synthesis of fluorinated organic molecules is of high interest for agrochemistry and pharmaceutics, but efficient and general reagents for introducing -CF2- groups are lacking. Here, the authors report the synthesis of 3,3-difluoropropen-1-yl ammonium salts as stable and scalable gem-difluoromethyla...
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| Autores principales: | , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/92708a3260d249239f5a4d4e1d32b26a |
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| Sumario: | Synthesis of fluorinated organic molecules is of high interest for agrochemistry and pharmaceutics, but efficient and general reagents for introducing -CF2- groups are lacking. Here, the authors report the synthesis of 3,3-difluoropropen-1-yl ammonium salts as stable and scalable gem-difluoromethylation reagents, which react with a range of nucleophiles under mild conditions and high regioselectivity. |
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