3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents

Synthesis of fluorinated organic molecules is of high interest for agrochemistry and pharmaceutics, but efficient and general reagents for introducing -CF2- groups are lacking. Here, the authors report the synthesis of 3,3-difluoropropen-1-yl ammonium salts as stable and scalable gem-difluoromethyla...

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Autores principales:	Fei Ye, Yao Ge, Anke Spannenberg, Helfried Neumann, Li-Wen Xu, Matthias Beller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/92708a3260d249239f5a4d4e1d32b26a
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spelling	oai:doaj.org-article:92708a3260d249239f5a4d4e1d32b26a2021-12-02T17:51:27Z3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents10.1038/s41467-021-23504-22041-1723https://doaj.org/article/92708a3260d249239f5a4d4e1d32b26a2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23504-2https://doaj.org/toc/2041-1723Synthesis of fluorinated organic molecules is of high interest for agrochemistry and pharmaceutics, but efficient and general reagents for introducing -CF2- groups are lacking. Here, the authors report the synthesis of 3,3-difluoropropen-1-yl ammonium salts as stable and scalable gem-difluoromethylation reagents, which react with a range of nucleophiles under mild conditions and high regioselectivity.Fei YeYao GeAnke SpannenbergHelfried NeumannLi-Wen XuMatthias BellerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fei Ye Yao Ge Anke Spannenberg Helfried Neumann Li-Wen Xu Matthias Beller 3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents
description	Synthesis of fluorinated organic molecules is of high interest for agrochemistry and pharmaceutics, but efficient and general reagents for introducing -CF2- groups are lacking. Here, the authors report the synthesis of 3,3-difluoropropen-1-yl ammonium salts as stable and scalable gem-difluoromethylation reagents, which react with a range of nucleophiles under mild conditions and high regioselectivity.
format	article
author	Fei Ye Yao Ge Anke Spannenberg Helfried Neumann Li-Wen Xu Matthias Beller
author_facet	Fei Ye Yao Ge Anke Spannenberg Helfried Neumann Li-Wen Xu Matthias Beller
author_sort	Fei Ye
title	3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents
title_short	3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents
title_full	3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents
title_fullStr	3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents
title_full_unstemmed	3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents
title_sort	3,3-difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/92708a3260d249239f5a4d4e1d32b26a
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_version_	1718379241074065408

3,3-Difluoroallyl ammonium salts: highly versatile, stable and selective gem-difluoroallylation reagents

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