Vagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis

Vagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis

Li-Na Zhang,1,* Xian-Wei Zhang,1,* Chang-Qing Li,2 Jing Guo,1 Yong-Ping Chen,1 Sheng-Li Chen1 1Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, 404000, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Chongqing Medical U...

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Autores principales: Zhang LN, Zhang XW, Li CQ, Guo J, Chen YP, Chen SL
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
vagal nerve stimulation
cerebral ischemia–reperfusion injury
autophagy
apoptosis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/9277899ff474461d9c881b52909343ad
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spelling oai:doaj.org-article:9277899ff474461d9c881b52909343ad2021-12-02T11:45:09ZVagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis1178-2021https://doaj.org/article/9277899ff474461d9c881b52909343ad2021-03-01T00:00:00Zhttps://www.dovepress.com/vagal-nerve-stimulation-protects-against-cerebral-ischemiandashreperfu-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Li-Na Zhang,1,* Xian-Wei Zhang,1,* Chang-Qing Li,2 Jing Guo,1 Yong-Ping Chen,1 Sheng-Li Chen1 1Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, 404000, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sheng-Li ChenDepartment of Neurology, Chongqing University Three Gorges Hospital, Number 165 Xincheng Road, Wanzhou District, Chongqing, 404000, People’s Republic of ChinaTel +86 58103452Fax +86 58103668Email chenshengli965@163.comBackground: Cumulative evidence suggests that neuronal death including autophagy, apoptosis, and necrosis is closely related to the occurrence and development of cerebral ischemia–reperfusion (I/R) injury. Moreover, vagal nerve stimulation (VNS) is involved in many different neuroprotective and neuroplasticity pathways. Thus, VNS may be a novel approach for treating various neurodegenerative diseases. The present study aims to determine whether VNS protects against cerebral I/R injury in rats by inhibiting autophagy and apoptosis.Methods: Cerebral I/R injury is induced by middle cerebral artery occlusion (MCAO) and VNS is carried out. Infarct volume, neurological deficit, autophagy, and apoptosis are examined 24 h after reperfusion.Results: Vagal nerve stimulation decreases infarct volume and suppresses neurological deficit. Moreover, obvious autophagy and apoptosis are detected in rats that have undergone I/R, and VNS inhibits autophagy and apoptosis.Conclusion: Vagal nerve stimulation exerts neuroprotective effects following I/R injury by inhibiting autophagy and apoptosis.Keywords: vagal nerve stimulation, cerebral ischemia–reperfusion injury, autophagy, apoptosisZhang LNZhang XWLi CQGuo JChen YPChen SLDove Medical Pressarticlevagal nerve stimulationcerebral ischemia–reperfusion injuryautophagyapoptosisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 905-913 (2021)
institution DOAJ
collection DOAJ
language EN
topic vagal nerve stimulation
cerebral ischemia–reperfusion injury
autophagy
apoptosis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle vagal nerve stimulation
cerebral ischemia–reperfusion injury
autophagy
apoptosis
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Zhang LN
Zhang XW
Li CQ
Guo J
Chen YP
Chen SL
Vagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis
description Li-Na Zhang,1,* Xian-Wei Zhang,1,* Chang-Qing Li,2 Jing Guo,1 Yong-Ping Chen,1 Sheng-Li Chen1 1Department of Neurology, Chongqing University Three Gorges Hospital, Chongqing, 404000, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sheng-Li ChenDepartment of Neurology, Chongqing University Three Gorges Hospital, Number 165 Xincheng Road, Wanzhou District, Chongqing, 404000, People’s Republic of ChinaTel +86 58103452Fax +86 58103668Email chenshengli965@163.comBackground: Cumulative evidence suggests that neuronal death including autophagy, apoptosis, and necrosis is closely related to the occurrence and development of cerebral ischemia–reperfusion (I/R) injury. Moreover, vagal nerve stimulation (VNS) is involved in many different neuroprotective and neuroplasticity pathways. Thus, VNS may be a novel approach for treating various neurodegenerative diseases. The present study aims to determine whether VNS protects against cerebral I/R injury in rats by inhibiting autophagy and apoptosis.Methods: Cerebral I/R injury is induced by middle cerebral artery occlusion (MCAO) and VNS is carried out. Infarct volume, neurological deficit, autophagy, and apoptosis are examined 24 h after reperfusion.Results: Vagal nerve stimulation decreases infarct volume and suppresses neurological deficit. Moreover, obvious autophagy and apoptosis are detected in rats that have undergone I/R, and VNS inhibits autophagy and apoptosis.Conclusion: Vagal nerve stimulation exerts neuroprotective effects following I/R injury by inhibiting autophagy and apoptosis.Keywords: vagal nerve stimulation, cerebral ischemia–reperfusion injury, autophagy, apoptosis
format article
author Zhang LN
Zhang XW
Li CQ
Guo J
Chen YP
Chen SL
author_facet Zhang LN
Zhang XW
Li CQ
Guo J
Chen YP
Chen SL
author_sort Zhang LN
title Vagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis
title_short Vagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis
title_full Vagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis
title_fullStr Vagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis
title_full_unstemmed Vagal Nerve Stimulation Protects Against Cerebral Ischemia–Reperfusion Injury in Rats by Inhibiting Autophagy and Apoptosis
title_sort vagal nerve stimulation protects against cerebral ischemia–reperfusion injury in rats by inhibiting autophagy and apoptosis
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/9277899ff474461d9c881b52909343ad
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